Ionis Pharmaceuticals, Inc.

Lead and execute healthcare compliance monitoring programs, analyze data for risk signals, and develop dashboards to inform executive decision-making. | Requires at least 8 years in healthcare compliance or related fields, with experience in monitoring, data analysis, and familiarity with industry regulations and tools. | Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! ASSISTANT DIRECTOR, COMPLIANCE OPERATIONS, MONITORING LEAD Summary The Assistant Director, Compliance Operations, Monitoring Lead reports to the Head of Compliance Operations and is responsible for the management and execution of Ionis’ risk-based healthcare compliance monitoring program. The role independently assesses adherence to Ionis’ healthcare compliance standards and leverages data analytics to deliver actionable compliance risk insights. This role is flexible for remote candidates in the U.S., with preference given to individuals located in or near the Boston, MA area to enable periodic on-site collaboration. Responsibilities • Develop and maintain the annual risk-based monitoring plan, including collaboration with third-party consultants to support execution and continuous program improvement • Lead and execute live (in-person and virtual) and transactional/desktop monitoring in partnership with other compliance team members and third-party consultants • Define, track, and report key performance indicators (KPIs) and key risk indicators (KRIs) to assess compliance risk trends and monitoring program effectiveness • Analyze monitoring data to identify trends, outliers, and emerging risk signals that inform monitoring priorities • Oversee remediation and corrective action plans, including tracking progress and ensuring timely and effective resolution of monitoring findings • Develop and maintain monitoring dashboards and reports (e.g., Excel, Tableau, Power BI, monitoring system) • Translate analytics and monitoring results into clear, executive-ready insights • Support monitoring system implementation and ongoing enhancement efforts • Partner cross-functionally with Commercial, Medical, Finance, IT, HR, and other stakeholders to align compliance activities • Provide compliance operational guidance and support for additional compliance initiatives, as needed Requirements • Bachelor’s degree required; advanced degree or relevant certification preferred • At least 8 years of experience in healthcare compliance monitoring or operations within the pharmaceutical, biotechnology, or life sciences industry, or 6 years with an advanced degree or relevant certification • Demonstrated knowledge of pharmaceutical compliance laws, regulations, and industry guidance (e.g., OIG, PhRMA, anti-kickback, anti-bribery) • Recent, hands-on experience with live field and transactional compliance monitoring • Advanced proficiency in Excel; experience with data visualization and dashboarding tools (e.g., Tableau, Power BI) • Demonstrated ability to analyze large datasets to identify trends, outliers, and compliance risks • Experience with compliance monitoring systems, including automated/AI-enabled monitoring tools, preferred • Proven ability to manage complex projects and external vendors effectively • Ability to operate independently and collaboratively in a fast-paced, matrixed environment, while exercising sound judgment • Effective verbal and written communication skills with the ability to convey complex information to diverse audiences • Demonstrated initiative, adaptability, and willingness to take on new responsibilities as business needs evolve • High degree of integrity and discretion in handling proprietary and confidential information • Occasional domestic travel (up to 20%) Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position; reference requisition # IONIS003978 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: https://ionis.com/careers#:~:text=Highly%20competitive%20benefits The pay scale for this position is $109,581 to $155,732 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Oversee and strategize the operations and initiatives of the Patient Innovation Lab, including vendor collaboration, training program design, and cross-functional engagement. | Requires 15+ years in pharma/healthcare with deep experience in training or innovation, along with strong leadership, project management, and communication skills. | Job Description: • Clarify and share vision of the Patient Innovation Lab as a Center of Excellence for Ionis • Showcase completed Patient Innovation Lab initiatives and define a prioritized annual roadmap aligned to Ionis business objectives • Proactively identify actions needed to elevate awareness and value of Patient Innovation Lab with operational partners, leadership, and cross functional partners • Actively discuss ways in which Patient Innovation Lab can support other functional areas and find opportunities to build confidence in what the Lab can deliver • Oversee the day-to-day operations of the Innovation Lab, including vendor collaboration, project management, and cross-functional activities • Serve as the strategic liaison between Patient Services subject matter experts and the Ionis Learning and Development team, ensuring training strategy and execution meet Patient Services and field needs • Lead the design of training program(s), partnering with subject matter experts and Learning and Development to incorporate adult learning principles and best practices • Proactively connect with Field and Patient Services leaders to identify continuous learning opportunities and a plan to address ongoing training needs • Hold our key operational vendor partners accountable to delivering operational excellence • Motivate vendor partners and Ionis’ dedicated teams to perform their best for Ionis’ programs • Engage vendor partners in understanding and addressing operational excellence gaps • Proactively plan for upcoming operational challenges with seamless execution Requirements: • Bachelor’s degree required; advanced degree (e.g., MBA, MHA, PharmD, PhD) strongly preferred • At least 15 years of pharmaceutical, biotech, consulting or healthcare services experience required, with recent deep experience in training or innovation • Experience leading initiatives with enterprise or cross-functional impact preferred • Passion for operations and operational details • Proven cross-functional leadership, project management, and collaboration skills • Outstanding customer relationship, communication, presentation and writing skills • Demonstrated ability to operate hands-on while influencing strategic outcomes • Strong knowledge of pharmaceutical specialty products preferred • Self-motivated & collaborative team player with strong interpersonal skills • Ability to effectively work with diverse audiences and influence cross-functionally • Ability to manage multiple priorities and deliver high-quality results in a fast-paced environment • Proficient in MS Office Suite Benefits: • Highly competitive benefits

Leading the transformation of the Patient Innovation Lab into a Center of Excellence and designing training programs for Patient Services. | Extensive experience in pharmaceutical or healthcare services, with a focus on innovation, training, and operational excellence, along with strong leadership and communication skills. | Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! DIRECTOR, PATIENT SERVICES INNOVATION & OPERATIONAL EXCELLENCE (TRAINING) Summary The Director, Patient Services Innovation and Operational Excellence is a pivotal leadership role reporting to the Executive Director, Patient Services Innovation and Operational Excellence, and is responsible for shaping and leading the transformation of the Patient Innovation Lab from a Patient Services-focused capability to an enterprise-wide Innovation Center of Excellence. In addition, this role is accountable for the design, governance, and delivery of Patient Services-related training for Ionis colleagues and field teams supporting commercialized products. Vendor management of our Patient Services operational partners may also be part of the responsibilities for this role. This position will be remote with preference for Southern California or Boston, Massachusetts. About The Patient Innovation Lab The Patient Innovation Lab is a cross-functional collaborative ecosystem to co-create with customers, drive better patient outcomes, and spotlight Ionis’ commitment to patients. It is a space where diverse internal and external perspectives and expertise spark collaborative understanding and transformation. The Patient Innovation Lab focuses on prioritizing excellence in every customer interaction, upholding Ionis’s commitment to every moment matters. Responsibilities Patient Innovation Lab • Clarify and share vision of the Patient Innovation Lab as a Center of Excellence for Ionis • Showcase completed Patient Innovation Lab initiatives and define a prioritized annual roadmap aligned to Ionis business objectives • Proactively identify actions needed to elevate awareness and value of Patient Innovation Lab with operational partners, leadership, and cross functional partners • Actively discuss ways in which Patient Innovation Lab can support other functional areas and find opportunities to build confidence in what the Lab can deliver • Oversee the day-to-day operations of the Innovation Lab, including vendor collaboration, project management, and cross-functional activities Patient Services Training • Serve as the strategic liaison between Patient Services subject matter experts and the Ionis Learning and Development team, ensuring training strategy and execution meet Patient Services and field needs • Lead the design of training program(s), partnering with subject matter experts and Learning and Development to incorporate adult learning principles and best practices • Proactively connect with Field and Patient Services leaders to identify continuous learning opportunities and a plan to address ongoing training needs Vendor Management • Hold our key operational vendor partners accountable to delivering operational excellence • Motivate vendor partners and Ionis’ dedicated teams to perform their best for Ionis’ programs • Engage vendor partners in understanding and addressing operational excellence gaps • Proactively plan for upcoming operational challenges with seamless execution Requirements • Bachelor’s degree required; advanced degree (e.g., MBA, MHA, PharmD, PhD) strongly preferred • At least 15 years of pharmaceutical, biotech, consulting or healthcare services experience required, with recent deep experience in training or innovation • Experience leading initiatives with enterprise or cross-functional impact preferred • Passion for operations and operational details • Proven cross-functional leadership, project management, and collaboration skills • Outstanding customer relationship, communication, presentation and writing skills • Demonstrated ability to operate hands-on while influencing strategic outcomes • Strong knowledge of pharmaceutical specialty products preferred • Self-motivated & collaborative team player with strong interpersonal skills • Ability to effectively work with diverse audiences and influence cross-functionally • Ability to manage multiple priorities and deliver high-quality results in a fast-paced environment • Proficient in MS Office Suite Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position; reference requisition #IONIS003904 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: https://ionis.com/careers#:~:text=Highly%20competitive%20benefits The pay scale for this position is $205,000 to $220,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.