Revolution Medicines

Build and lead the global pricing function, develop strategies, and ensure compliance for a biopharma company. | Extensive experience in biopharma pricing, market access, and global health policy, with leadership in a similar role. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Executive Director, Global Pricing will serve as the company’s first dedicated Global pricing leader, responsible for building the global pricing function, infrastructure, and strategy to support the commercial launch and long-term value optimization of the company’s innovative therapies. This leader will establish global pricing governance, partner to develop launch pricing strategies, and ensure pricing decisions align with clinical value, market access goals, and the company’s mission to deliver transformative medicines to patients. The Executive Director will work cross-functionally with Market Access, Commercial, HEOR, Finance, Regulatory, Clinical, and program teams to shape pricing considerations. The position will report to the VP, Global Value, Access and Pricing. Responsibilities: Global Pricing • Design and implement the company’s first global pricing framework, policies, SOPs, governance committees, and approval workflows. • Develop global pricing infrastructure including systems, tools, analytics platforms, dashboards, and documentation standards. • Define the operating model for pricing interactions and partnering with future regional teams. • Create foundational IRP, net-price management tools and processes. • Develop portfolio wide pricing principles, policies and advance best practices to optimize value recognition by stakeholders globally. • Establish a compliant global pricing governance model with clear decision-rights and escalation pathways. • Ensure adherence to global regulatory requirements, including national pricing rules, IRP risks, anti-trust considerations. • Implement controls to monitor price changes, discounting, contracting, and tender strategy. • Lead strategic initiatives related to product launches, price optimization and analytics. • Engage with Regions to incorporate payer, policy insights and global trends into enterprise pricing strategies. Stakeholder Engagement, Cross-Functional and Team Leadership • Develop and maintain strong business relationships with key functions with a focus on Clinical, Commercial, Regulatory, and Finance. • Collaborate with regional pricing teams, IT and Finance to ensure data quality, system integrity and actionable insights. Policy, Risk & External Engagement • Coordinate with regions to align on policy and legislation risks that could impact global pricing strategies and tactics. Required Skills, Experience & Education: • Bachelor’s degree required; advanced degree in Finance, Pharmacy, Health Economics, Life Sciences, or Business preferred (e.g., PharmD, PhD, MBA). • Minimum 15+ years of progressive leadership in market access, pricing, and / or finance within the biopharma industry. • Demonstrated ability to build a new Pricing function to support a Global Market Access commercialization strategy. • Deep understanding of global payer systems and HTA processes. • Experience designing and implementing global pricing strategy, including value-based pricing, launch sequencing, and reference pricing mitigation. • Proven ability to work cross-functionally and influence executive leadership in a dynamic, resource-constrained, early-stage company. Preferred Skills: • Prior experience with pharmaceutical pricing strategy in U.S. and global markets. Strong understanding of global health systems, health policy, pricing regulations, reimbursement environments and familarity with key U.S. and Global price policy trends. • Familiarity with rare disease, or oncology product launches. • Strong executive presence, with the ability to clearly articulate complex pricing issues to both internal and external stakeholders. • Experience building or scaling global pricing function in a pre-commercial or newly commercial biotech company. The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $256,000—$320,000 USD

Build and lead the global pricing function, develop policies, and support product launches in a biopharma setting. | Extensive experience in biopharma pricing, market access, and global health policy, with leadership in setting up new pricing functions. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Executive Director, Global Pricing will serve as the company’s first dedicated Global pricing leader, responsible for building the global pricing function, infrastructure, and strategy to support the commercial launch and long-term value optimization of the company’s innovative therapies. This leader will establish global pricing governance, partner to develop launch pricing strategies, and ensure pricing decisions align with clinical value, market access goals, and the company’s mission to deliver transformative medicines to patients. The Executive Director will work cross-functionally with Market Access, Commercial, HEOR, Finance, Regulatory, Clinical, and program teams to shape pricing considerations. The position will report to the VP, Global Value, Access and Pricing. Responsibilities: Global Pricing Design and implement the company’s first global pricing framework, policies, SOPs, governance committees, and approval workflows. Develop global pricing infrastructure including systems, tools, analytics platforms, dashboards, and documentation standards. Define the operating model for pricing interactions and partnering with future regional teams. Create foundational IRP, net-price management tools and processes. Develop portfolio wide pricing principles, policies and advance best practices to optimize value recognition by stakeholders globally. Establish a compliant global pricing governance model with clear decision-rights and escalation pathways. Ensure adherence to global regulatory requirements, including national pricing rules, IRP risks, anti-trust considerations. Implement controls to monitor price changes, discounting, contracting, and tender strategy. Lead strategic initiatives related to product launches, price optimization and analytics. Engage with Regions to incorporate payer, policy insights and global trends into enterprise pricing strategies. Stakeholder Engagement, Cross-Functional and Team Leadership Develop and maintain strong business relationships with key functions with a focus on Clinical, Commercial, Regulatory, and Finance. Collaborate with regional pricing teams, IT and Finance to ensure data quality, system integrity and actionable insights. Policy, Risk & External Engagement Coordinate with regions to align on policy and legislation risks that could impact global pricing strategies and tactics. Required Skills, Experience & Education: Bachelor’s degree required; advanced degree in Finance, Pharmacy, Health Economics, Life Sciences, or Business preferred (e.g., PharmD, PhD, MBA). Minimum 15+ years of progressive leadership in market access, pricing, and / or finance within the biopharma industry. Demonstrated ability to build a new Pricing function to support a Global Market Access commercialization strategy. Deep understanding of global payer systems and HTA processes. Experience designing and implementing global pricing strategy, including value-based pricing, launch sequencing, and reference pricing mitigation. Proven ability to work cross-functionally and influence executive leadership in a dynamic, resource-constrained, early-stage company. Preferred Skills: Prior experience with pharmaceutical pricing strategy in U.S. and global markets. Strong understanding of global health systems, health policy, pricing regulations, reimbursement environments and familarity with key U.S. and Global price policy trends. Familiarity with rare disease, or oncology product launches. Strong executive presence, with the ability to clearly articulate complex pricing issues to both internal and external stakeholders. Experience building or scaling global pricing function in a pre-commercial or newly commercial biotech company. The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $256,000—$320,000 USD

Lead global market access, pricing, and reimbursement strategies for oncology assets, ensuring alignment across regions and supporting clinical development and launch activities. | Over 15 years of leadership in biopharma market access, experience with ex-U.S. launches, and deep understanding of global payer systems and HTA processes. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: This position will lead the development and execution of global market access and pricing strategies for assets in the key disease area of NSCLC, and work with regions to build resources to support optimal access these assets. The role ensures that the CDPs and asset positioning is developed with an access strategy and pricing reimbursement perspective that is aligned across all regions. This individual will collaborate closely with the Health Economics and Outcomes Research (HEOR), Medical and Region Market Access teams to align global and regional initiatives and play a key role in business development access strategies. In addition, define the product’s value narrative/Global Value dossier planning and development, guide pricing and reimbursement including net pricing corridors, optimal country launch sequence and ensure sustainable access in key global markets. Reporting to the VP, Global Value, Access and Pricing, this role will work cross-functionally to influence long-term growth, patient impact, and company valuation. Responsibilities: Global Value, Access & Pricing Strategy Formulate and define asset and disease area pricing and reimbursement strategies to support optimal access and reimbursement outcomes across all target regions. This includes asset global pricing architecture and launch sequencing strategy to develop net price corridors, reference pricing and value-based designs. Craft a differentiated global value proposition and oversee the development of the Global Value Dossier (GVD) and payer negotiation materials. Work closely with members of the Disease Area Strategy teams to help shape priority clinical development plans and combinations with both RevMed and oncology combination therapy opportunities. Design and implement strategic plans to support clinical development programs to ensure study designs, endpoints, and analyses generate the evidence needed for payer and HTA submissions including seeking systematic HTA advice. Identify and assess global market access risks and opportunities, integrating them into product strategies and reflecting them in Target Product Profiles (TPPs). Partner with Clinical Development and Regulatory Affairs to incorporate payer and patient relevant evidence into clinical development strategies. Collaborate closely with the HEOR team to ensure alignment between market access needs and health economic research plans for pipeline assets. Engage with Regions to incorporate payer, policy insights and global trends into product access strategy. Launch Readiness & Market Engagement Lead global payer research and work with regions to gain actionable early engagement/advice from key HTA bodies (e.g., G-BA, NICE, HAS, AIFA, Chuikyo). Develop and maintain strong business relationships with key functions responsible for value proposition enablement with a focus on Clinical, Commercial, Regulatory, Medical Affairs, and HEOR stakeholders. Prepare and submit HTA and reimbursement dossiers in priority markets with clear alignment to clinical and economic evidence plans. Cross-Functional and Team Leadership Partner with Medical Affairs, HEOR, Regulatory, and Clinical to align evidence generation with access and reimbursement needs. Build strong cross-funtional relations and build a high-performing team that coordinates closely with regional leads and country affiliates. Serve as a key leader within the global launch team, actively contributing to go-to-market planning, demand forecasting, and gross-to-net-scenario modeling. Policy, Risk & External Engagement As required, represent the company externally with payers, HTA bodies, trade associations, and policy groups, helping shape access environments. Coordinate with the U.S. region to align on policy and legislation risks that could impact life cycle management pricing corridors. Required Skills, Experience & Education: Bachelor’s degree required; advanced degree in Pharmacy, Health Economics, Public Health, Life Sciences, or Business preferred (e.g., PharmD, PhD, MBA). Minimum 15+ years of progressive leadership in market access, pricing, and HEOR within the biopharma industry. Demonstrated success launching a first-in-class or specialty therapy in ex-U.S. markets (especially Germany, France, and Japan). Demonstrating the ability to build a new capability and framework to support a Global Market Access commercialization strategy. Established network of relationships with key stateholders and organizations in Global Market Access landscape Experience engaging HTA and payer organizations in early advice to inform development and trial strategies Deep understanding of global payer systems and HTA processes, including AMNOG, Chuikyo, NICE, and other EU frameworks. Experience designing and implementing global pricing strategy, including value-based pricing, launch sequencing, and reference pricing mitigation. Proven ability to work cross-functionally and influence executive leadership in a dynamic, resource-constrained, early-stage company. Preferred Skills: Prior experience with Ex-U.S. and U.S. legislation and public policies that impact Global and regional decisions (U.S. IRA, MFN, EU regulations etc.) Familiarity with rare disease, or oncology product launches. Experience working with external vendors, consultants, and access agencies to develop payer research, modeling, and dossier development. Strong executive presence, with the ability to clearly articulate complex value stories to both internal and external stakeholders. Experience building or scaling global market access functions in a pre-commercial or newly commercial biotech company. The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $256,000—$320,000 USD

Manage and negotiate clinical site contracts and budgets, ensuring compliance and timely execution, supporting process improvements, and collaborating with cross-functional teams. | Extensive experience in clinical contract management, strong oncology background, knowledge of FDA and ICH guidelines, and proven negotiation skills. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Revolution Medicines is seeking a motivated individual Senior Manager, Clinical Site Contracts, who will support all processes related to site contracts and budgets. The individual will be responsible for but not limited to drafting, advising, negotiating and executing clinical site agreements. Ensures final contracts and contract terms are consistent with organizational strategy, delivered by agreed upon timelines, falls within Fair Market Value and in compliance with legal, financial & regulatory requirements. This role is an individual contributor with team leadership responsibilities, reporting into the Associate Director, Site Contracts. Must have strong oncology experience. Ability to manage a high volume of site contract agreements from start to finish. Support all site contract and budget activities related to clinical trials. Ensure consistency of contract terms with company policies and goals and best practices to enhance the contracting process. Ensure smooth, timely, and accurate implementation of all contract terms. Accountable for the timely preparation and execution of all site contracts and budgets. Responsible for entering contracts into CMS. Demonstrated experience with clinical budget build/development using (FMV), and historical data (Grant Plan). Strong negotiation of MCTA, ICTAs, CTAs, CSAs, CDAs, other site agreements and budgets with investigator sites (directly or with support where language necessitates), using appropriate templates, guidance, and legal/budget playbooks, liaising with ClinOps, Finance and Legal for approval. Provide input for ongoing updates of applicable legal contracts and budget playbooks and templates. Ensure appropriate tracking of various agreements. Effectively escalate/communicate in a timely manner to stakeholders and clinical teams regarding contract issues that could impact project deliverables. Lead process improvement projects and continuous improvement in delivery of Global Contract Management responsibilities. Demonstrate a high level of applicable competencies in contract management, critical thinking, highly competent in negotiation and contracting business standards. Ensure the execution of end-to-end process is robust and is established as a way of effectively supporting the needs of key business partners while continuously monitoring and further enhancing service quality, efficiency and effectiveness and lead or support continuous improvement initiatives. Manage contract workflow and collaboration with senior leaders to ensure efficient contract execution and suggest and implement new / more efficient processes as needed. Responsible for measuring and reporting metrics and Key Performance Indicators (“KPIs”) for in scope service deliverables. Participation in team meetings and collaborate with other functional groups within the company to achieve clinical study goals. Ensure contracts and budgets are completed on time, within budget and in compliance with Standard Operating procedures (SOPs), FDA regulations and International Council for Harmonization (ICH)/ GCP guidelines. Communicate effectively within cross functional project teams at Revolution Medicines. Required Skills, Experience and Education: B.S., 10-14 years equivalent related business/ industry experience. Experience in pharmaceutical, biotech, academia, CROs (Clinical Research Organizations). Strong computer skills: Microsoft office and software to manage contracting. Demonstrated leadership, stakeholder influencing without authority and negotiation skills. Strong knowledge of a wide variety of clinical-related contract types, including, clinical trial site agreements, investigator sponsored trial agreements, research collaboration agreements, consulting agreements and confidentiality agreements. 5 + years experience with clinical budget negotiation. Strong analytical and contract administration skills, verbal and written communication skills, and the ability to interact effectively with internal and external business partners. High degree of dedication, motivation, and ability to work under pressure with a drive for results and the ability to engage and deliver through others. Experience working in a global environment. Strong working knowledge of FDA Regulations, ICH Guidelines and GCPs governing the conduct of clinical trials. Strong problem-solving skills with sound technically driven decision-making ability. An innovative team-player with capacity to be effective in a dynamic and fast-paced company environment. Strong Oncology experience necessary. Preferred Skills: Big pharma/CRO experience a plus. Grant Plan experience a plus. #LI-Hybrid #LI-DN1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $158,000—$198,000 USD

Lead global oncology marketing strategies, oversee product launch and lifecycle planning, and collaborate across functions to maximize commercial success. | 15+ years in biotech/pharma marketing with proven success in global product launches, strategic planning, and leadership. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Reporting to the VP, Global Commercial Development Disease Area Lead, this newly created role will serve as a leader for continuing to build our global oncology marketing capabilities driving global commercial strategy at product team and overseeing global launch strategy and lifecycle planning for a given indication/indications. Candidates should be passionate about leading cross-functional collaboration, and contributing as both a strategic leader and hands-on driver in a growing organization. This position is primarily remote with travel required for scientific and team meetings. Specifically, you will be responsible for: Partner across the company including with clinical development, medical affairs, market access, to drive indication strategy, shape brand strategies across the product team. Ensure global readiness to drive successful launch planning, commercialization, and performance tracking across the U.S. and key ex-U.S. markets. Execute global disease area strategy, brand strategies, including branding, positioning, messaging, and value propositions that guide regional affiliates and align with long-term portfolio goals. Translate scientific and market insights into compelling strategies, launch narratives, and execution plans; effectively communicating recommendations and leading strategic discussions with global and regional stakeholders. Develop and refine global brand plans, including revenue and patient forecasts, to inform investment decisions, lifecycle strategies, and portfolio prioritization. Drive excellence in global launch execution: creating launch frameworks, ensuring best practices are shared across affiliates, and monitoring progress to anticipate and resolve challenges. Identify and manage external agencies, vendors, and partners to deliver impactful global campaigns, educational initiatives, and engagement platforms. Serve as a trusted resource to executive leadership in identifying opportunities to maximize commercial value, expand indications, and differentiate in competitive markets. Bring innovation and new capabilities to global marketing—collaborate with IS Commercial to integrate digital, omnichannel, and data-driven approaches to build a best-in-class commercial function. Up to 50% of travel required. Required Skills, Experience and Education: Bachelor’s degree required (MBA preferred) with at least 15+ years of progressive commercial experience in a biotechnology and/or pharmaceutical company including strategic marketing and ideally sales. Proven success of developing and executing global marketing strategy. Experience in leading the global launch of new product in competitive spaces. Demonstrated ability to derive insights/analytics leading to the development of innovative marketing strategies. Strong leadership, with the ability to lead teams, work well cross-functionally, and influence across the organization to create a clear sense of direction. Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines. Ability to represent Revolution Medicines well externally: strong interpersonal skills including verbal and written communication. Entrepreneurial mindset, with a tolerance for ambiguity, and a passion for helping cancer patients. Preferred Skills: Experience with an oncology launch is desired. Prior experience in a smaller, rapidly growing, company. Experience in gastrointestinal or lung cancer preferred. #LI-Hybrid #LI-SS2 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $256,000—$320,000 USD

Leading clinical operations infrastructure, strategy, and team development for biotech clinical trials. | Extensive experience in clinical operations, leadership in biotech/pharma, knowledge of FDA/ICH/GCP, and vendor management. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: This is a unique opportunity for the right individual who has innate and proven leadership and organizational skills, People mentoring and staff management professional, technical expertise in Clinical Operations Structure and Procedure in an industry setting, and experience in organizing clinical operations. As the Executive Director in Clinical Operations, you will be responsible for the operational design and structure of, and accountable for the implementation and continuation of, procedures, governance and expansions of processes and procedure to enable Revolution Medicines clinical trials. Specifically, responsibilities include: Mentors and represent Clinical Operations Study Teams view with clinical vendor outsourcing leaders to synergize strategy, including building efficiencies, collaboration with internal and external stakeholders. Shapes clinical operations infrastructure, to support high quality, efficient conduct and inspection ready clinical trials including but not limited to: Staff development tools, clinical processes alignment and standardization, inspection ready clinical document management processes, and other systems. Identifies gaps, aligns building of solutions and drives the evaluation, selection, deployment, and oversight of clinical operational resolutions. Identifies and builds achievable standards that allow for consistent oversight and content management of clinical operations systems such as but not limited to eTMF, Feasibility Work, LMS, Medical CRM, CTMS). Oversees Clinical Operations resource planning tracking and general strategy by partnering with RevMed management and appropriate fellow Clinical Operations and Functional Team to support clinical study execution. Leads Clinical Operations teams and builds partnerships with cross functional operations to ensure quality, timely and fiscally responsible deliverables across the RevMed portfolio. Cultivates collaborations with other functional groups to produce mutually beneficial, purposeful and operational objectives, deliverables, and creative solutions that meet current Global Industry ICH/GCP standards. Is a RevMed resource for Clinical Operations Systems, and actively forecasts plus acts to ensure Clinical Development plan/ programs meet RevMed goal. As requested, may cross over into leading study functions and/or assume leadership responsibilities beyond mentorships. Leads and grows Clinical Operations function and staff with a culture of respect, honesty, curiosity, empowerment and accountability for the achievement of their commitments and goals (company and personnel). Required Skills, Experience and Education: BS/MS Degree in a scientific discipline with a minimum of 15 years of clinical operations experience in the pharmaceutical or biotech industry, preferably the majority in oncology drug development. Minimum of 10 years clinical operations systems project and line management experience. Extensive experience in leading and managing global phase 1-3 clinical trials within designated timelines, resources, and budgets and translating the experiences into operational systems. A demonstrable record of strong leadership and teamwork. Extensive experience in selection of CROs/ vendors and management of external resources. Must have a working knowledge of data management, data review and analysis, and drug safety, pharmacovigilance and other related functions related to clinical trial conduct. Strong working knowledge of FDA Regulations, ICH Guidelines and GCPs governing the conduct of clinical trials. Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high-energy environment. Excellent written and verbal communication skills. Ability to act as an excellent ambassador for Revolution Medicines in interactions with key opinion leaders, scientific advisors, corporate partners and, where necessary, investors. Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute goals as a member of an interdisciplinary team is extremely important. Preferred Skills: Experience in working with cooperative group studies and investigator sponsored trials preferred. #LI-Hybrid #LI-GL1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $256,000—$320,000 USD

Leading operational excellence, strategic planning, and cross-functional coordination within a biotech research organization. | Master's in Life Sciences, >10 years in Pharma/Biotech, experience in drug discovery, leadership in complex initiatives, budget and contract management. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The head of the Integrated Research Management group is a key leadership role responsible for strengthening operational excellence, advancing strategic planning, and enabling the continued evolution of our Research organization. This leader will enhance cross-functional coordination, upgrade operational systems, and ensure the organization is equipped for future growth. The ideal candidate brings deep Discovery experience and excels at working with executive-level stakeholders on high-impact matters. They lead multiple diverse groups, influence decision-making, and translate long-range Research strategy into actionable and sustainable operational plans. This role also includes people-management responsibilities and plays an important part in shaping team culture, group dynamics, and organizational effectiveness. Contributes to the strategic and operational direction for the Research organization; partners with executive leaders to define and execute critical initiatives. Applies a deep understanding of Discovery, adjacent functions, and the competitive landscape to inform operational decisions and business priorities. Drives organizational effectiveness through systems thinking, process optimization, and infrastructure development. Provides strategic problem-solving and guidance across ambiguous, complex, and multi-functional challenges. Translates multi-sub-functional strategy into actionable objectives, systems, and processes that strengthen research performance and organizational readiness. Leads major change initiatives, ensuring durable adoption of new operational models, technologies, and ways of working. Breaks down silos and enhances cross-functional coordination, communication, and decision-making across diverse research groups. Oversees business operations for Research, including budgeting, financial planning, resource forecasting, CRO management, and academic collaboration contracts. Actively engages in the Integrated Research Hub leadership team; builds capabilities, fosters effective group dynamics, and promotes a high-performance culture. Serves as a role model for RevMed Core Values, creating an inclusive, collaborative, and forward-looking research environment. Required Skills, Experience and Education: Master’s degree in a Life Sciences discipline. Deep understanding of drug discovery organizations, >10 years in Pharmaceutical or Biotech industry experience. Executive presence and ability to influence without authority. Operational and strategic capability in equal measure. Expertise in organizational assessment, systems thinking, program management, and change leadership. Experience leading cross-functional groups and complex initiatives. Comfort navigating ambiguity and solving abstract problems to provide clear guidance. Experience managing budgets, contracts, and external partnerships. Strong people leadership, fostering positive group dynamics, and shaping culture. Advanced capability with MS Office software (Excel, PowerPoint, and Word), collaboration platforms (Smartsheet, Teams, Coda), workflow applications and visualization tools (Timeline Pro, LucidCharts, OnePager). Preferred Skills: MBA or PhD in Life Sciences, is a plus. Experience in Oncology therapeutic area is strongly preferrable. #LI-Hybrid #LI-LN1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $236,000—$295,000 USD

Provide administrative and project execution support for US Commercial Field teams including meeting logistics, event planning, travel coordination, recruitment support, and expense processing. | Bachelor's degree with 3+ years of executive-level administrative experience in project management or business operations, preferably in biopharma or life sciences, with strong organizational and communication skills. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Project Coordinator role is essential to execution and achievement of goals and objectives of the US Commercial Field teams providing administrative support and project execution across the leadership and team members including: Provides administrative support across remote field team members in different time zones and project executional support for key field events, activities and initiatives. Leads meeting support managing logistics, room reservations, catering, audio-visual equipment set-up, and assists in creation, preparation, organization and communications of key meeting materials for all field team meetings, trainings and regional/division meetings. Interacts with various stakeholders including field leaders, cross functional business partners and external vendors/ agencies. Establishes processes, timelines and milestones to plan and execute on key field events and initiatives. Plans and coordinates conference attendance and related activities, including conference registration, hotel stays, reception arrangements, catering, and logistics for external events (i.e., speaker series, ad boards, KOL meetings) Plans and coordinates domestic and international travel details including flights, VISA applications, travel documents, car transports, hotel bookings, restaurant reservations and other travel related needs of senior field leaders as needed; this may require evening or weekend support, depending on the travel requirements. Handles recruitment and onboarding activities including all full-time, temporary, and consulting candidate interview scheduling for the functions supported, as well as coordinating 1st day of new hire planning w/HR and hiring manager. Coordinates expense report processing and reconciliation of receipts and credit card statements for senior field leaders as needed. Provides presentation slides support: consolidation, formatting, content organization as requested. Works with Contract Administration team and business partners to coordinate consulting and/or master service agreements in partnership with legal to ensure they are in place and executed properly, including within approval limits, to support functional groups. Fosters an open, inclusive, and collaborative culture within US Commercial function. Partners with Commercialization Operations and Administration team members to find synergies across activities. Required Skills, Experience and Education: Bachelor’s degree required with 3+ years of administration experience supporting at the executive level with progressive experience in project management or business operations in biopharma or life sciences. Exhibits impeccable integrity and sound judgment to handle highly sensitive and confidential material and information. Strong organizational, project and time management skills; detail oriented and ability to manage multiple deliverables. Ability to prioritize and multi-task projects and demands effectively. Ability to collaborate with multiple stakeholders across field teams, cross functional partners, and/or external vendors. Willingness to support Revolution Medicines to succeed by thinking outside of the box and job description. Able to adapt to changes in the work environment. Professional demeanor and team-player while maintaining positive, team-focused attitude. Proactive and excellent self-initiative. Excellent verbal and written communication skills. Preferred Skills: Biotechnology experience highly preferred. Proficient with MS Word, Excel, PowerPoint, and Outlook calendar. Experience with applicant tracking systems highly preferred. Experience with project management tools, (i.e. SmartSheet) and communications platforms (i.e., Teams portal development, newsletters) is a plus. #LI-Hybrid #LI-SS2 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $96,000—$120,000 USD

Lead and manage computer system validation activities ensuring compliance with regulatory requirements and inspection readiness for GxP computerized systems in pharmaceutical operations. | Minimum 10 years of GxP computer system validation experience in pharma/biopharma, knowledge of regulatory standards (21 CFR Part 11, Annex 11, GAMP 5), and ability to lead multiple CSV projects. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are seeking a seasoned IT/Quality Assurance professional with expertise in the life sciences industry to join our team as Senior Manager, Computer System Validation (CSV). In this role, you will be responsible for ensuring the compliance and validation of GxP-relevant computerized systems supporting pharmaceutical and biopharmaceutical operations. As a key member of the IS Quality team, you will lead CSV activities across regulated and business-critical enterprise systems. This includes hands-on development and execution of risk-based validation strategies, authoring and reviewing validation documentation, and ensuring adherence to regulatory requirements and industry best practices. This position serves as a strategic liaison between Information Sciences (IS), Quality Assurance (QA), and functional business teams, supporting system implementation and change initiatives to ensure inspection readiness and ongoing compliance. The Senior Manager, CSV will report directly to the Director, IS Quality. Key Responsibilities: • Partner with IS, QA and external vendors in the validation and delivery of new GxP computerized systems and manage change control activities for existing validated systems. • Provide direct support for the Computer System Validation (CSV) program, including the development of System Change Requests, System Risk Classifications, ERES Assessments, User Requirement Specifications, Functional Specifications, Configuration Specifications, Validation Plans, Risk Assessments, Test Protocols and Reports, Traceability Matrices, Data Migration Plans, and other validation execution deliverables. • Review and audit of computer system validation deliverables according to 21 CFR Part 11, Annex 11 and other regulatory requirements. • Collaborate with System/Business Owners and Quality to assess and classify computerized systems for regulatory impact (GxP, SOX, HIPAA, Privacy, PCI). • Ensure the execution of data integrity assessments and partner with IS, Business Owners and Quality for effective controls. • Author and revise CSV procedures, forms, and templates for continuous improvement. • Own CSV-related deviations and CAPAs, managing remediation efforts. • Ensure GxP computerized systems remain in a validated state and inspection ready. • Maintain the computerized system inventory. • Facilitate Periodic Reviews for systems and perform Audit Trail reviews. • Support GxP computer system audits and ensure qualification of computer system vendors. Required Skills, Experience and Education:  • Minimum Bachelor’s Degree in engineering or life science related field. • Minimum 10 years in GXP computer system validation experience in the pharmaceutical/ biopharma space. • Extensive knowledge of GxP regulations, CSV/CSA principles, 21 CFR Part 11, Annex 11, GAMP 5, and Data Integrity concepts and controls for computerized systems. • In-depth knowledge of GAMP 5, software development, lifecycle methodologies and current industry best practices. • Must have broad GxP electronic system experience preferably in a Bio-pharma sponsor organization. • Maintains awareness of current and upcoming FDA Computer Software Assurance (CSA) principles. • Familiarity with Quality, Regulatory, and Clinical Data Management platforms such as Veeva, TraceLink, Trial Interactive, Medidata, etc. • Experience with electronic signature and document management systems i.e., DocuSign Part 11, Veeva QualityDocs, Egnyte GXP. • Understanding of CSV expectations for cloud-based/SaaS systems. • Ability to lead and manage multiple CSV projects for complex computer systems. • Experience supporting regulatory inspections and audits. • Experience working with all levels of management and consulting with key business stakeholders. An ability to influence greater outcomes. • Results-oriented with the capacity to execute projects with minimal supervision. • Possess strong written and verbal communication skills. • Attention to detail and quality. • Knowledge of IT security frameworks such as NIST, ISO/IEC 27001, SOC 2 a plus. • Familiarity with privacy regulations such as GDPR, CCPA, HIPAA a plus. #LI-Hybrid #LI-YG1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $158,000—$198,000 USD

Lead global patient safety science activities including safety surveillance, risk management, regulatory submissions, and mentoring safety scientists across multiple complex drug development programs. | 8+ years drug development experience with 4+ years in safety science, postgraduate life sciences degree, strong regulatory and clinical leadership skills, and ability to lead a high-performing team. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Director, Global Patient Safety Science provides safety science and pharmacovigilance support to all products across the RevMed portfolio, which includes early and late phase development activities as a member of the Global Patient Safety team. The individual will be responsible for safety oversight and input into all aspects of study management across the portfolio. This position may have individual reporting to it depending on the program/portfolio being led. The Director of Safety Science serves as the lead for multiple or large complex strategically important developmental programs. Also, works closely with the other functions as part of a flexible matrix team to conduct robust safety assessments and safety risk management activities. The Director, Global Patient Safety Science will develop and maintain an expert understanding of the safety profile of the assigned product(s) as well as an understanding of the relevant strategic context (e.g., disease under study, safety profile of competitors, mechanism of action, etc.) and is accountable for oversight of benefit/risk safety profile of allocated products through the product lifecycle.. Specifically, you will be responsible for: • Responsible for safety surveillance and risk management activities including, but not limited to medical review of ICSRs, routine review of safety data, and pertinent scientific literature articles. Contribute to the review of assessments for safety signals or in response to Regulatory Authority requests. • Providing medical safety input into the design and conduct of pharmacoepidemiology and observational studies • Plan and interpret safety data analyses, prepare and present safety data summaries to internal and external stakeholders. • Acquire and contribute knowledge of relevant drug class and/or competitor safety issues. • Lead the development of safety surveillance strategy, identify potential clinical safety issues, and recommend appropriate risk mitigation measures. • Establish and maintain collaborative working relationships with all key stakeholders (e.g., clinical study teams, safety CROs, business partners) which require expert contribution to the development of the product safety strategy. • Accountable for risk management activities including preparation and maintenance of relevant sections of clinical trial protocols, IBs (including the reference safety information section), ICFs, DSURs, RMPs, CCDS, and labelling, as required. • Contribute to regulatory authority submissions (Investigational New Drug applications, New Drug Applications, Marketing Authorization Applications, etc.). • Developing response strategies in collaboration with safety committee members, providing medical-scientific input to regulatory documents for safety-related requests from health authorities and other external parties. • Evaluates risk minimization strategies and takes accountability for the medical-scientific content in the Risk Management Plans, including risk minimization measures, risk minimization action plans and REMS programs, as relevant • Accountable for the safety components of study reports (i.e., CSRs), aggregate reports (DSUR, PSUR/PBRER, PADER) and other regulatory documents. • Participate in internal and external Data Monitoring Committees through review of safety data, insights and leadership and development of DMC Charters • Reviews publications, including abstracts, manuscripts, and speaker presentations. • Trains and mentors Safety Scientists • Consistently comply with all governing laws, regulations, RevMed standard operating procedures (SOPs) and other guidelines. Required Skills, Experience and Education: • 8 or more years of drug development experience in the pharmaceutical or related industry, of which at least 4 years include prior Safety Science experience, which includes performance of medical review, safety surveillance/signal detection, and other related risk management activities. • A relevant postgraduate qualification (e.g., MD, PharmD, PhD/MSc in a Life sciences discipline, or other post-graduate health professional qualifications). • Mentor, and lead a high-performing Safety Science team. • Excellent ability to evaluate, interpret and present scientific data with clarity. • Proven success in creating and sustaining strong relationships with internal and external business partners across an organization to create positive partnerships. • Experience with interacting with Regulatory Authorities (i.e. FDA, EMA) at type C, B, pre-BLA/MAA meetings, Advisory Committee meetings, or other scientific advice forums. • Strong analytical and strategic thinking, problem-solving, and decision-making skills. • Excellent communication, collaboration, and team management abilities. • Extensive understanding of pharmacovigilance and risk management. • Strong clinical leadership and experience. • Outstanding emotional intelligence. Preferred Skills: • Demonstrated ability to lead and influence in a global matrix environment. • 2+ years of experience in Oncology clinical development • Proficiency in managing regulatory interactions, BLA/MAA experience. • Strong organizational and time management skills, with the ability to prioritize and manage multiple tasks effectively. • Excellent influence and collaboration/teamwork capabilities. • Strong interpersonal and communication (written and verbal) skills The base salary range for this full-time position is $204,000 to $255,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Lead and build the global market access and pricing team to develop strategies for optimal reimbursement and access of oncology therapies worldwide. | 18+ years of leadership in global market access, pricing, and reimbursement in biopharma, advanced degree preferred, experience launching specialty therapies globally, and deep knowledge of payer systems and HTA processes. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. Our pipeline includes RAS(ON) Inhibitors designed to target diverse oncogenic RAS protein variants. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. As we prepare for the global commercialization of our first product, initially Pancreatic Cancer, we are building the Global Commercial Development organization. We are seeking a visionary, enterprise-minded leader to establish and lead the Global Market Access & Pricing team. This role will be instrumental in shaping global market access and pricing strategies, pricing architecture and value narratives that are resonant across diverse payer landscapes. The position reports to the SVP, Global Commercial Development, and will serve as a core member of the global commercial development leadership team, and work cross-functionally to influence long-term growth, patient impact, and company valuation. Responsibilities: Global Value, Access & Pricing Strategy • Formulate and define pricing and reimbursement strategies to support optimal access and reimbursement outcomes across target markets/regions. • Develop a global pricing architecture, reference pricing mitigation, net pricing corridors and an optimal launch sequencing strategy. • Craft a compelling global payer and healthcare system value proposition, oversee the development of the Global Value Dossier (GVD) and payer negotiation materials, and disseminate to target markets/regions. • Partner with members of the Disease Area Strategy teams, to help shape clinical development priorities - including RevMed medicines and combination regimens. • Ensure clinical development programs generate the right evidence needed for payer/HTA evaluations (study designs, endpoints, etc) • Identify global market access risks and opportunities, integrating insights into product strategies and Target Product Profiles (TPPs). • Partner with clinical development and regulatory affairs to incorporate payer and patient relevant endpoints into clinical development plans. • Work closely with the HEOR team to ensure 1) alignment between market access needs and health economic research plans for pipeline assets; and 2) full integration of adequate HEOR/evidence deliverables in the global access strategy. • Engage with Region teams to incorporate payer, policy insights and global trends into access planning. Launch Readiness & Market Engagement • Lead global payer research and early engagement with HTA bodies (e.g., G-BA, NICE, HAS, AIFA, Chuikyo). • Build and maintain strong cross-functional partnerships with Clinical, Commercial Development, Regulatory, Medical Affairs, and HEOR, • Prepare and submit reimbursement and HTA dossiers in priority markets aligned with the global access and commercialization strategy. Cross-Functional and Team Leadership • Partner with Medical Affairs, HEOR, Regulatory, and Clinical to ensure integrated evidence strategies reflect payers’ needs. • Build and lead a high-performing Global Market Access team and partner closely with regional leads and country affiliates. • Serve as a key leader within the global launch team, actively contributing to go-to-market planning and strategy, demand forecasting, and gross to net scenario modeling. Policy, Risk & External Engagement • Monitor evolving global policies and evaluate their impact on access, portfolio and disease area strategies is (e.g., IRA, international reference pricing, transparency laws, EU HTA/JCA, Medical Research Act, etc.). • Represent the company externally with payers, HTA bodies, trade associations, and policy groups, helping positively shape access environments. • Coordinate with the U.S. & other regions to align on policy and legislation risks that could impact life cycle management and pricing corridors. Required Skills, Experience and Education: • Bachelor’s degree required; advanced degree in Pharmacy, Health Economics, Public Health, Life Sciences, or Business strongly preferred (e.g., PharmD, PhD, MBA). • 18+ years of progressive leadership in global market access, pricing, and reimbursement within the biopharma industry. • Demonstrated success launching a first-in-class or specialty therapy in the U.S. and multiple ex-U.S. markets (especially Germany, France, and Japan). • Demonstrated ability to build global market access strategy from the ground up. • Deep understanding of global payer systems and HTA processes, including AMNOG, Chuikyo, NICE, and other EU frameworks. • Experience designing and implementing global pricing strategy, including value-based pricing, launch sequencing, and reference pricing mitigation. • Proven ability to work cross-functionally and influence executive leadership in a dynamic, resource-constrained, early-stage company. Preferred Skills: • Prior experience with Ex-U.S. and U.S. legislation and public policies that impact Global and regional decisions (U.S. IRA, MFN, EU regulations etc.) • Oncology or rare disease product launch experience preferred. • Deep experience working with external vendors, consultants, and access agencies to develop payer research, modeling, and dossier development. • Strong executive presence, with the ability to clearly articulate complex value stories to both internal and external stakeholders. • Track record of building or scaling global market access functions in a pre-commercial or newly commercial biotech company. • Strong solution orientation and enterprise mindset. The base salary range for this full-time position is $284,000 to $355,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. #LI-Remote

Develop and implement global CMC regulatory strategies to support clinical development and marketing approval. Lead the preparation of CMC sections for regulatory submissions and provide regulatory support throughout the product lifecycle. | Candidates should have a BA/BS degree in a relevant field and over 10 years of experience in pharmaceutical or biotech drug development. A solid understanding of global CMC regulatory affairs and experience with leading submissions is essential. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: This position is responsible for developing and implementing CMC regulatory strategies. The role involves coordinating and preparing CMC sections of regulatory submissions to support the clinical development and eventual marketing approval of RevMed’s pipeline compounds/products. Responsibilities: Develop, lead, and implement global CMC regulatory strategies to support the clinical development through registration and post-marketing activities. Lead the preparation and maintenance of the CMC / quality sections for regulatory submissions including initial submission of IND, IMPD/CTA, NDA, MAA and amendments to Health Authorities (HAs), and preparation of responses to queries from HAs. Serve as the CMC regulatory representative on project teams and provide CMC regulatory support for the clinical development of the investigational product(s) and ensure applicable regulatory requirements are appropriately met. Collaborate with corporate regulatory team, CMC SMEs and/or CROs to identify regional/country-specific CMC requirements to support global applications, and to drive the CMC submission timelines in order to meet business objectives. Provide regulatory assessment and guidance on CMC related change controls, deviations, and investigations throughout product life cycle. Lead and/or contribute to internal process improvements, SOP development, and organizational initiatives to support globalization of RevMed’s products. Maintain knowledge of global competitive landscape, regulatory environment, regulations and CMC guidance, providing interpretation to internal stakeholders. Required Skills, Experience, and Education: BA/BS degree in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related field. 10+ years of pharmaceutical / biotech drug development experience with 5 + years of experience of global CMC regulatory affairs. Experience in leading CMC related global submissions (IND, IMPD/CTA, NDA, MAA, etc.) (US, EU, APAC, LATAM). Solid knowledge of US and international GMP quality regulations, current industry practices, and experience with interpretation and application to development projects and marketed product regulatory issues. Demonstrated experience in effective collaboration with internal and external stakeholders. Ability to prioritize and manage multiple projects simultaneously in a dynamic company environment. Effective written and verbal communication skills and excellent interpersonal skills. Preferred Skills: Advanced degree (MSc or PhD degree) in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related field is desirable. Working experience and content knowledge in CMC development of NCEs / small molecules or equivalent. Self-driven, proactive, and able to operate independently while fostering collaboration across departments. Ability and desire to coach and mentor junior regulatory CMC RA staff. #LI-Hybrid #LI-CT1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $180,000—$225,000 USD

Lead and execute the European Medical Affairs strategy for oncology, build and manage the regional medical affairs team, collaborate with global and local stakeholders, and support clinical trials and market access activities. | Advanced scientific degree with 10+ years oncology medical affairs leadership experience, strong knowledge of European oncology landscape, proven team leadership, and excellent communication and collaboration skills. | Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Reporting to the Senior Vice President (SVP) Head of Europe, the Vice President & Head of Europe Medical Affairs will lead the development and execution of RevMed’s Medical Affairs strategy across the European Region, ensuring alignment with global objectives and local needs. This leadership role is critical to maximizing the opportunity for RevMed Innovation to impact patients across the region. In collaboration with the SVP Head of Europe and the SVP Head of Global Medical Affairs, the successful medical leader will develop and execute comprehensive regional medical strategies to accelerate engagement with European key stakeholders (government authorities, regulatory authorities, payer authorities, physicians). This leader will ensure that regional medical considerations are embedded in the global medical strategy and plans and will partner with the SVP Head of Europe and their leadership team including GMs and their country medical affairs and market access teams to ensure that reimbursement and access considerations are integrated in the existing and future clinical program design of the company portfolio/pipeline. The incumbent will be responsible for building and leading the European medical affairs team and working closely with the Country Medical Affairs teams across Med Affairs functions including Med Info, Pharmacovigilance & HEOR. Responsibilities: Lead the development and execution of the European Medical Affairs strategy for RevMed’s portfolio, ensuring alignment with global objectives and local market needs. As directed by the commercialization strategy, build and lead the European Medical Affairs team, working with cross-functional leaders to ensure that each team member and function executes against the clear and well-aligned business objectives. Serve as the regional medical expert across the oncology portfolio, providing guidance and close partnership with clinical development, clinical operations, market access, regulatory strategy, and commercialization plans. Work with the global team to drive regional scientific communication activities, including publication planning, congress strategy, and development of medical education programs. Provide medical insight and leadership on cross-functional teams, including Global Medical Affairs, Europe Regulatory Affairs, Clinical Development & Clinical Operations, Commercial, Market Access, and Safety. Ensure all medical activities adhere to ethical, regulatory, and compliance standards. Support the medical review of promotional materials and contribute to internal training and capability building for oncology medical teams. Develop and manage the Europe Region Medical Affairs budget, in alignment with the SVP, Head of Europe. Foster a culture consistent with the global RevMed values and vision/mission. Clinical Collaboration in line with regulatory/compliance requirements: Collaborate with US and global teams to initiate and support clinical trials in Europe, ensuring adherence to regulatory guidelines and timelines. Work closely with clinical operations, medical affairs, market access, and regulatory teams to facilitate smooth startup and execution. Provide strategic input to global teams in the US on the selection of endpoints, comparators, patient populations, and study designs to ensure clinical trials generate meaningful data. Support the groundwork for Phase I-III clinical trials by identifying potential clinical trial sites, establishing relationships with investigators, and supporting preparation of regulatory submissions. Establish and maintain collaborative relationships with Key Opinion Leaders (KOLs), academic institutions, cooperative groups, professional societies, and healthcare providers. Develop and maintain strong relationships with Key Opinion Leaders (KOLs) in the field of pancreatic and lung cancer. Engage with KOLs to gather insights, validate clinical development plans, and support market development activities. Leverage KOL relationships to enhance the company's scientific and commercial credibility in European markets. Build and maintain relationships with other key stakeholders, including healthcare professionals and organizations, country and region regulatory bodies, patient advocacy groups, and industry partners. Facilitate effective communication between internal teams and external partners to align goals and expectations. Represent the company at international and European conferences, industry events, and regulatory meetings to promote our cell therapy products and company mission. Collaborate to support European Market Access/Early Access Programs Oversee medical input into HTA submissions, payer engagement strategies, and external expert consultations to support market access and reimbursement. Lead planning and development of expanded access programs in the region, as appropriate. Provide regional input into the design of Real-World Evidence (RWE) initiatives, Phase IV studies, and Investigator-Sponsored or Collaborative Research. Required Skills, Experience and Education: Advanced scientific degree required (MD, PhD, or PharmD) with a specialization or significant experience in oncology. Minimum 10 years of relevant experience in Medical Affairs within oncology, including regional or global leadership roles. Proven ability to lead medical strategy and engage effectively with external oncology experts and stakeholders. Demonstrated ability to build and lead a high-performing medical affairs team. Strong leadership and influencing skills with the ability to create a clear sense of direction. Strong knowledge of the European oncology landscape, including regulatory frameworks, treatment guidelines, and reimbursement pathways. Experience with scientific data generation, clinical trial interpretation, and communication of complex data to diverse audiences. Ability to create and nurture a strong culture of collaboration and authenticity to extend and replicate the RevMed culture at the regional level. Highly organized and motivated individual possessing excellent communication, presentation and interpersonal skills. Strong team orientation and passion for continuous self and team development. Ability to flexibly lead; willingness to learn new therapeutic areas and technologies. Thrives in a fast-paced, dynamic small company environment and able to adjust priorities and workload based upon changing needs. Preferred Skills: Experience with oncology launches is desired. Experience in gastrointestinal and lung cancers preferred. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. 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