Alnylam Pharmaceuticals

Lead strategy, governance, and delivery of enterprise HCM system with AI-driven HR solutions. | Bachelor's degree plus 10+ years in HR technology or enterprise systems leadership with SuccessFactors expertise. | Overview The Director, Digital HR Platforms is responsible for leading the strategy, governance, delivery, and optimization of Alnylam’s core HR platform. This role will oversee Alnylam’s enterprise Human Capital Management (HCM) system, SuccessFactors, ensuring the platform is customer centric, scalable, integrated, and aligned with enterprise architecture. The Director will also lead data foundations, data governance, integrations, and release management to ensure HR technology is reliable, compliant, and capable of supporting advanced analytics and AI-driven insights. Reporting to the Executive Director, HR Digital Strategy ​& AI Integration​, this leader will serve as the primary conduit between HR and IT for platform strategy, integration design, and digital enablement. Key Responsibilities Digital HR Platform Strategy & Ownership Develop and execute a multi-year digital HR platform strategy aligned to HR, business, and enterprise technology priorities. Serve as the platform owner for SuccessFactors, including Core HR, Compensation, Benefits, Talent Management, Time Tracking, and Learning, ensuring cohesive architecture and user experience. Drive platform design decisions that balance standardization, scalability, and business evolution. Ensure platform stability, data integrity, role-based security, and compliance with regulatory requirements. Oversee product roadmap across all SuccessFactors modules, ensuring alignment with business needs and enterprise architecture. Data Foundations & Governance Lead the development of HR data foundations, including data models, data flows, and data quality frameworks. Establish and maintain HR data governance standards in partnership with HR, IT, and enterprise data teams. Ensure HR data is accurate, accessible, and structured to support analytics, reporting, and AI-driven insights. Partner with the Insights & Innovation team to enable advanced analytics and workforce planning capabilities. Integrations & Release Management Oversee the design, development, and maintenance of integrations across HR, IT, Finance, and enterprise systems. Lead release management processes, including regression testing, change control, and communication. Ensure seamless coordination with IT on architecture, middleware, and integration standards. Maintain documentation, audit readiness, and operational support processes. AI, Automation & Digital Enablement Identify opportunities to apply AI, automation, and workflow orchestration across HR platforms. Partner with HR Innovation, Analytics, and IT to scale digital solutions such as genAI, intelligent case management, and automated workflows. Promote digital-first, self-service, and automation-oriented approaches across HR operations. Stay current with emerging HR technologies and evaluate tools that enhance scalability and innovation. Stakeholder Partnership & Governance Act as the strategic partner to HR COEs, HRBPs, People Operations, IT, Finance, Legal, and other stakeholders. Translate business requirements into scalable platform and data solutions. Lead HR technology governance forums to prioritize demand, manage enhancements, and align stakeholders on roadmap decisions. Support change management, communication, and adoption efforts to maximize value from HR platforms. Leadership & Team Development Build and lead a high-performing team across platform management, data governance, integrations, and release management. Foster a culture of accountability, continuous improvement, and innovation. Serve as a visible leader and subject matter expert across HR and the enterprise. Qualifications Bachelor’s degree in Human Resources, Information Systems, Business, or related field, or equivalent experience. 10+ years of progressive experience in HR technology, digital platforms, or enterprise systems leadership. Experience managing SuccessFactors, as an enterprise HCM solution. Demonstrated success leading integrations, data governance initiatives, and large-scale platform optimization. Strong stakeholder partnership skills with the ability to influence and collaborate across HR, IT, and business functions. Experience with AI, automation, or digital enablement. Experience in global and/or regulated environments preferred. About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment. #LI-MH1 #LI-Hybrid The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers U.S. Pay Range $205,700—$278,300 USD

Lead complex cyber investigations and incident response across global environments while driving end-to-end containment and recovery. | 8+ years incident response, digital forensics, or threat hunting experience with strong scripting and automation skills. | Overview Alnylam is pioneering RNAi therapeutics and scaling rapidly across research, development, manufacturing, and global commercialization. The Associate Director, Cyber Defense – Staff Incident Responder will play a critical role in protecting the enterprise by leading complex cyber investigations and advancing detection and response capabilities across a global environment. Reporting to the Senior Director, Cyber Defense, this senior individual contributor will operate in a highly technical, hands-on capacity—driving incident response, forensic analysis, and threat hunting while shaping how Alnylam detects, investigates, and responds to advanced threats. This role will also help evolve detection and response capabilities through tooling, automation, and scalable engineering approaches. This is a hybrid position, primarily based in Cambridge, MA and includes participation in an on-call rotation, with flexibility to support incident response outside standard business hours, as needed. Responsibilities Lead complex cyber investigations and incident response across global environments, driving end-to-end containment, eradication, and recovery Perform advanced forensic analysis and proactive threat hunting to identify attacker behavior, persistence mechanisms, and lateral movement Translate investigation findings into scalable improvements in detection coverage, telemetry, and response effectiveness Develop and enhance incident response playbooks, investigation workflows, and containment strategies based on real-world threats Improve response speed and effectiveness through detection engineering, alert tuning, automation, and removal of systemic bottlenecks Build and evolve incident response tooling, scripts, and integrations to enable scalable and efficient operations Influence and optimize the security tooling ecosystem to improve signal quality, visibility, and investigative outcomes Lead post-incident analysis, producing clear, actionable reports that drive remediation and strengthen security posture Partner cross-functionally to drive remediation, hardening, and long-term risk reduction across the enterprise Provide technical leadership and mentorship to junior responders while guiding best practices across Cyber Defense Qualifications 8+ years of hands-on experience in incident response, digital forensics, threat hunting, or security operations within enterprise environments (including cloud) Deep investigative expertise across endpoint, cloud, network, and identity domains, including correlation of multi-source telemetry and forensic artifacts Strong scripting and automation skills (e.g., Python, Go, PowerShell, Bash) to support scalable investigation and response workflows Proven ability to independently lead complex investigations and make high-confidence technical decisions in high-pressure environments Strong understanding of attacker tactics, techniques, and procedures, including experience with frameworks such as MITRE ATT&CK Experience applying industry incident response frameworks (e.g., NIST, CISA) in real-world scenarios Demonstrated impact improving detection and response through tooling, process, or program enhancements Experience leading cross-functional initiatives with enterprise-wide impact Strong communication skills, with the ability to translate technical findings, risks, and recommendations for technical and non-technical stakeholders About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment. #LI-MH1 #LI-Hybrid The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers U.S. Pay Range $174,300—$235,700 USD

Lead global logistics design standards and manage cross-functional collaboration to ensure product integrity and risk mitigation. | Bachelor's degree and 5+ years in cold chain, logistics, or regulated distribution environments. | Overview The Manager, Logistics Design & Cold Chain will support the development, implementation, and continuous improvement of global logistics design standards to help ensure product integrity across Alnylam’s end-to-end supply chain network. This role will contribute to packaging strategy, transportation lane design, temperature-controlled shipping requirements, and logistics risk mitigation in partnership with Global Logistics Operations, Quality, Validation, Clinical and Commercial Supply Chain, CMOs, 3PLs, and logistics service providers. This position will serve as a key operational and technical partner responsible for translating logistics design requirements into practical, scalable processes that support consistent, compliant, and reliable product movement. The role will focus on execution of defined logistics design initiatives, lane assessments, packaging and transportation standards, and continuous improvement opportunities across cold chain and broader temperature-sensitive logistics operations. This position is hybrid and will be primarily located in Cambridge, MA. Key Responsibilities Logistics Design & Network Governance Support the development and maintenance of global packaging and transportation strategies across various products, shipment types, and temperature profiles Partner with Packaging Engineering, Validation, Quality, and Operations to define lane routing, carrier selection, pack-out requirements, and lane design inputs Facilitate approval processes for packaging, validation and transportation configurations based on risk, performance and business needs Identify and mitigate logistics risks (lane variability, disruptions, packaging performance) and define contingency strategies Standards & Compliance Establish global standards for temperature control and environmental conditions across all shipment profiles Ensure alignment between packaging, validation, transportation strategy, and product requirements to maintain product integrity Facilitate the creation of logistics design policies, standards, and SOPs, and lead their implementation across assigned products, lanes, and logistics partners Ensure compliance with GDP/GMP and regulatory requirements in partnership with Quality & Validation Partner with internal teams and external providers to implement standardized logistics design practices across assigned products, lanes, or initiatives Risk Management Assess transportation and cold chain risks for assigned lanes, products, or logistics scenarios Support the development of risk-based mitigation plans in partnership with Packaging Engineering, Validation, Quality, and Logistics Operations Monitor lane and provider performance to identify potential product integrity or service reliability risks Cross-Functional Execution & Partner Engagement Serve as a logistics design and cold chain point of contact for assigned projects, lanes, or operational initiatives Collaborate with CMOs, 3PLs, logistics service providers, Quality, Validation, Manufacturing, Clinical Supply, Commercial Supply, and Trade Compliance Support cross-functional decision-making related to transportation design, packaging configuration, lane setup, and shipment readiness Continuous Improvement & Innovation Identify opportunities to standardize and optimize logistics strategies across the global network Drive improvements in service reliability, cost efficiency, and product protection Analyze shipment performance, lane data, excursion trends, and carrier performance to recommend improvements Evaluate and implement innovative technologies and solutions that enhance logistics performance and visibility Qualifications Bachelor’s degree in Supply Chain, Logistics, Life Sciences, or a related discipline Minimum 5 years of experience in logistics, cold chain, supply chain operations, packaging, transportation, or regulated distribution environments Experience supporting temperature-controlled logistics, packaging qualification, lane assessments, or product integrity programs Strong knowledge of GDP/GMP transportation requirements and regulated supply chain operations Proven ability to work cross-functionally with Quality, Validation, Operations, and external partners Strong communication skills with the ability to work cross-functionally and influence without direct authority. Ability to travel up to 20-25%, globally About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment. The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers U.S. Pay Range $122,400—$165,500 USD