Alnylam Pharmaceuticals

Lead complex cyber investigations and incident response across global environments while driving end-to-end containment and recovery. | 8+ years incident response, digital forensics, or threat hunting experience with strong scripting and automation skills. | Overview Alnylam is pioneering RNAi therapeutics and scaling rapidly across research, development, manufacturing, and global commercialization. The Associate Director, Cyber Defense – Staff Incident Responder will play a critical role in protecting the enterprise by leading complex cyber investigations and advancing detection and response capabilities across a global environment. Reporting to the Senior Director, Cyber Defense, this senior individual contributor will operate in a highly technical, hands-on capacity—driving incident response, forensic analysis, and threat hunting while shaping how Alnylam detects, investigates, and responds to advanced threats. This role will also help evolve detection and response capabilities through tooling, automation, and scalable engineering approaches. This is a hybrid position, primarily based in Cambridge, MA and includes participation in an on-call rotation, with flexibility to support incident response outside standard business hours, as needed. Responsibilities Lead complex cyber investigations and incident response across global environments, driving end-to-end containment, eradication, and recovery Perform advanced forensic analysis and proactive threat hunting to identify attacker behavior, persistence mechanisms, and lateral movement Translate investigation findings into scalable improvements in detection coverage, telemetry, and response effectiveness Develop and enhance incident response playbooks, investigation workflows, and containment strategies based on real-world threats Improve response speed and effectiveness through detection engineering, alert tuning, automation, and removal of systemic bottlenecks Build and evolve incident response tooling, scripts, and integrations to enable scalable and efficient operations Influence and optimize the security tooling ecosystem to improve signal quality, visibility, and investigative outcomes Lead post-incident analysis, producing clear, actionable reports that drive remediation and strengthen security posture Partner cross-functionally to drive remediation, hardening, and long-term risk reduction across the enterprise Provide technical leadership and mentorship to junior responders while guiding best practices across Cyber Defense Qualifications 8+ years of hands-on experience in incident response, digital forensics, threat hunting, or security operations within enterprise environments (including cloud) Deep investigative expertise across endpoint, cloud, network, and identity domains, including correlation of multi-source telemetry and forensic artifacts Strong scripting and automation skills (e.g., Python, Go, PowerShell, Bash) to support scalable investigation and response workflows Proven ability to independently lead complex investigations and make high-confidence technical decisions in high-pressure environments Strong understanding of attacker tactics, techniques, and procedures, including experience with frameworks such as MITRE ATT&CK Experience applying industry incident response frameworks (e.g., NIST, CISA) in real-world scenarios Demonstrated impact improving detection and response through tooling, process, or program enhancements Experience leading cross-functional initiatives with enterprise-wide impact Strong communication skills, with the ability to translate technical findings, risks, and recommendations for technical and non-technical stakeholders About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment. #LI-MH1 #LI-Hybrid The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers U.S. Pay Range $174,300—$235,700 USD

Lead clinical supply and operations planning and develop manufacturing strategies to meet program and budget requirements while collaborating cross-functionally. | Master's degree with 5+ years or Bachelor's with 8+ years in bioservices/biopharma, expertise in ERP implementation, supply chain planning, and strategic data-driven decision-making. | Sr. Manager, Global Planning Job Description Summary: Key contributor to clinical supply and operations planning monthly team meeting (CS&OP). Contribute and advise on Partner Sales and Operation Demand Reviews. Work cross-functionally to develop scenario plans and strategies that result in production plans that meet program, capacity, and budget requirements. Leads and supports others in the group to provide strategic planning and execution recommendations. Collaborate with external partners to ensure that Drug Substance and Drug Product supply needs are met in line with contractual obligations. Develop short- and long-term manufacturing plans using clinical development plans from program management and CMC. Partners with CMC, Process Sciences, Program Team, QA, QC, Finance and Material Management to ensure material availability is in line with clinical program timelines and budget. Troubleshoot and identify root causes and suggest solutions to meet project objectives. Develop Annual Long Range Manufacturing Plans based on available information, highlighting areas of constraint. Utilize and oversee SAP master data integrity to ensure inventory and order management is accurate and precise. Qualifications: Master’s degree in Global Supply Chain Management, Business (any), Engineering (any), Science (any) or related field of study in Bioservices or Biopharma industries and five (5) years of experience in the job offered or related occupation in which the required experience was gained. In lieu of a Master’s degree in Global Supply Chain Management, Business (any), Engineering (any), Science (any) or related field of study in Bioservices or Biopharma industries and five (5) years of experience, the employer will also accept a Bachelor’s degree in Global Supply Chain Management, Business (any), Engineering (any), Science (any) or related field of study and eight (8) years of experience in Bioservices or Biopharma industries. Must have demonstrated experience with: ERP implementation – successfully implementing ERP to help launch new tools and pharmaceutical products and substances; Supply Chain Planning – Balancing production, inventory, and distribution; Strategic Thinking – Aligning plans with business objectives; Data Analytics – Using data to drive planning decisions; Cross-Functional Collaboration – Working effectively across multiple different departments; Project Management – Coordinating new product launches and key initiatives; Communication & Stakeholder Management – Influencing and aligning global teams with constant changing assumptions; SAP or Oracle; Scenario Planning – Evaluating alternative demand, supply, and market scenarios to support decision-making; and Change Management – Leading and adapting to organizational, process and market changes effectively. Salary offered for the position is: $175,635 .00 - $185,200.00 / year. Primary Work Location: 100 Main Street, 13th Floor, Cambridge, MA 02142 Additional Locations: N/A Work Shift: Not Specified To apply, submit a resume to https://jobs.alnylam.com/careers?start=0&pid=893380660936&sort_by=hot, OR submit a resume to https://jobquest.dcs.eol.mass.gov/jobquest/LandingPage.aspx OR mail resume to: Alnylam US, Inc., Attn: HR, 675 West Kendall Street, Cambridge, MA 02142. Must reference Job Title & Job Code: 3570. EOE. About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment. The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers U.S. Pay Range $136,900—$185,200 USD

Lead global logistics design standards and manage cross-functional collaboration to ensure product integrity and risk mitigation. | Bachelor's degree and 5+ years in cold chain, logistics, or regulated distribution environments. | Overview The Manager, Logistics Design & Cold Chain will support the development, implementation, and continuous improvement of global logistics design standards to help ensure product integrity across Alnylam’s end-to-end supply chain network. This role will contribute to packaging strategy, transportation lane design, temperature-controlled shipping requirements, and logistics risk mitigation in partnership with Global Logistics Operations, Quality, Validation, Clinical and Commercial Supply Chain, CMOs, 3PLs, and logistics service providers. This position will serve as a key operational and technical partner responsible for translating logistics design requirements into practical, scalable processes that support consistent, compliant, and reliable product movement. The role will focus on execution of defined logistics design initiatives, lane assessments, packaging and transportation standards, and continuous improvement opportunities across cold chain and broader temperature-sensitive logistics operations. This position is hybrid and will be primarily located in Cambridge, MA. Key Responsibilities Logistics Design & Network Governance Support the development and maintenance of global packaging and transportation strategies across various products, shipment types, and temperature profiles Partner with Packaging Engineering, Validation, Quality, and Operations to define lane routing, carrier selection, pack-out requirements, and lane design inputs Facilitate approval processes for packaging, validation and transportation configurations based on risk, performance and business needs Identify and mitigate logistics risks (lane variability, disruptions, packaging performance) and define contingency strategies Standards & Compliance Establish global standards for temperature control and environmental conditions across all shipment profiles Ensure alignment between packaging, validation, transportation strategy, and product requirements to maintain product integrity Facilitate the creation of logistics design policies, standards, and SOPs, and lead their implementation across assigned products, lanes, and logistics partners Ensure compliance with GDP/GMP and regulatory requirements in partnership with Quality & Validation Partner with internal teams and external providers to implement standardized logistics design practices across assigned products, lanes, or initiatives Risk Management Assess transportation and cold chain risks for assigned lanes, products, or logistics scenarios Support the development of risk-based mitigation plans in partnership with Packaging Engineering, Validation, Quality, and Logistics Operations Monitor lane and provider performance to identify potential product integrity or service reliability risks Cross-Functional Execution & Partner Engagement Serve as a logistics design and cold chain point of contact for assigned projects, lanes, or operational initiatives Collaborate with CMOs, 3PLs, logistics service providers, Quality, Validation, Manufacturing, Clinical Supply, Commercial Supply, and Trade Compliance Support cross-functional decision-making related to transportation design, packaging configuration, lane setup, and shipment readiness Continuous Improvement & Innovation Identify opportunities to standardize and optimize logistics strategies across the global network Drive improvements in service reliability, cost efficiency, and product protection Analyze shipment performance, lane data, excursion trends, and carrier performance to recommend improvements Evaluate and implement innovative technologies and solutions that enhance logistics performance and visibility Qualifications Bachelor’s degree in Supply Chain, Logistics, Life Sciences, or a related discipline Minimum 5 years of experience in logistics, cold chain, supply chain operations, packaging, transportation, or regulated distribution environments Experience supporting temperature-controlled logistics, packaging qualification, lane assessments, or product integrity programs Strong knowledge of GDP/GMP transportation requirements and regulated supply chain operations Proven ability to work cross-functionally with Quality, Validation, Operations, and external partners Strong communication skills with the ability to work cross-functionally and influence without direct authority. Ability to travel up to 20-25%, globally About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment. The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers U.S. Pay Range $122,400—$165,500 USD

Provide high-level administrative support to senior leaders, managing calendars and travel while handling sensitive information. | Minimum 5 years experience, preferably with a college degree, strong Microsoft Office skills, and excellent organizational and communication abilities. | Overview We are seeking a highly skilled and experienced Executive Assistant to provide consistent, high-level administrative support to senior leaders within the Finance Team. This role requires a proactive, detail-oriented professional who thrives in a fast-paced environment and can balance multiple priorities with discretion and efficiency. The ideal candidate will demonstrate exceptional proficiency in Microsoft Office, strong project management capabilities, and outstanding communication skills. Success in this role will be defined by the ability to manage complex schedules, navigate competing demands, maintain confidentiality, and support both individual and team objectives with a collaborative and solutions-oriented mindset. This position is hybrid and will be primarily located in Cambridge, MA. Responsibilities Manage complex and dynamic calendars for senior executives, including scheduling internal and external meetings, resolving conflicts, and partnering effectively with other administrative professionals. Coordinate domestic and international travel arrangements, including flights, lodging, transportation, and meeting logistics with internal and external stakeholders. Serve as a communication liaison, managing and prioritizing incoming emails and requests; organize conference calls, Zoom meetings, agendas, and presentation materials. Handle sensitive and confidential information with the utmost discretion and professionalism. Provide additional support as needed for broader finance department including travel, scheduling ad-hoc meetings and coordinating guests. Act as a collaborative member of the Executive Assistant team, participating in team meetings and initiatives, and supporting cross-coverage and shared responsibilities. Qualifications College Degree preferred with a minimum of 5 years related experience required. Experience within the life sciences industry and/or supporting a finance function is highly desirable. Prior experience supporting senior finance leaders is strongly preferred. Demonstrated excellence in verbal and written communication, with meticulous attention to detail, grammar, and accuracy. Advanced proficiency in Microsoft Office Suite, particularly Outlook, PowerPoint, Excel, and Word. Exceptional organizational and time-management skills. Proven ability to work independently and take initiative. Strong interpersonal skills with a collaborative, team-oriented mindset. High integrity and discretion as well as sound judgment in managing sensitive and confidential information. Comfortable navigating shifting priorities and tight deadlines in a rapidly evolving environment. Resourceful, solutions-focused, and committed to excellence in execution in a fast-paced organization. #LI-MH1 #LI-Hybrid U.S. Pay Range $93,500.00 - $126,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Oversee clinical supply execution and collaborate with cross-functional teams to manage risks and compliance. | Bachelor's degree and 5+ years clinical supply chain experience with knowledge of GxP and clinical trial operations. | Overview: We are seeking an individual for the role of Manager – Clinical Supply Chain, Operations. In this position, you will play a pivotal role in ensuring reliable, compliant execution of clinical supply across programs, supporting Alnylam’s growing pipeline and patient needs. Your focus will be on overseeing end-to-end clinical supply execution activities across assigned protocols, ensuring timely delivery of materials to sites and patients. You will partner closely with cross-functional teams including Clinical Operations, Quality Assurance, Regulatory Affairs, and external vendors to execute clinical trials effectively. Overall, you will be accountable for ensuring uninterrupted supply, managing operational risks, and delivering execution excellence across protocols in a dynamic environment. This position is hybrid and will be primarily located in the Alnylam Cambridge office. Responsibilities: Responsible for end-to-end execution of clinical supply activities including IRT, packaging, labeling, distribution, inventory management, returns, destruction, and study closeout Ensure protocol milestones are met on time and in full (e.g., FPI, SIV readiness, on-time delivery to sites/patients) Partner cross-functionally with Clinical Operations, QA, Regulatory, and CMOs to ensure efficient and compliant execution Manage and escalate day-to-day execution risks including delays, deviations, and supply disruptions with clear escalation and mitigation Oversee temperature excursions and supply deviations ensuring appropriate documentation and resolution Ensure execution activities are compliant, well-documented, and inspection-ready Maintain visibility to inventory levels and supply availability across programs Contribute to continuous improvement of execution processes, tools, and ways of working Train fellow trial leads Qualifications: B.Sc. in a scientific field or Supply Chain Management or related field 5+ years of direct Clinical Supply Chain experience globally Demonstrated knowledge of clinical supply chain packaging, labeling, inventory management, global distribution Strong understanding of clinical trial operations and drug development lifecycle Foundational knowledge of GMP / GxP / GCP and global regulatory requirements (FDA, EU, etc.) Experience with systems/tools (IRT/IXRS, inventory systems, Excel, Smartsheet, ERP) Risk identification, assessment, and mitigation Project management across multiple studies/programs Vendor / CMO / CRO management and oversight Budget tracking, cost control, and financial oversight of protocols Problem-solving and risk-based decision making Proficient knowledge of MS Office (Excel, PowerPoint, Visio, Project, etc) Excellent communication, attention to detail, collaboration, ability to manage complex challenges, and influencing skills #LI-KB1 #LI-Hybrid U.S. Pay Range $122,400.00 - $165,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.