Vertex Inc.

Lead strategy, roadmap, and execution for AI-powered indirect tax audit workflows, including automating notice responses and evidence gathering. | Requires 10+ years, hands-on tax audit management and notice-response workflow experience, and a proven product-management track record; tax technology or compliance experience is preferred. | Job Description: The Senior Principal Product Manager - Audit AI is a senior individual contributor responsible for leading product management for Vertex's AI-powered Audit workflows for Indirect Tax. We are looking for a visionary leader to define, build, and scale our AI-first solution for Indirect Tax Audit and Notice Management. Tax authorities worldwide are digitizing, resulting in an unprecedented volume of complex notices and aggressive audits for enterprises. This role will own the product strategy, roadmap, and execution for an intelligent solution that transforms how businesses triage, gather, interpret, and respond to audits. This is a high-impact leadership role at the intersection of Generative AI, document intelligence, and enterprise fintech. The Senior Principal Product Manager role will own the full product lifecycle of this new category defining AI first solution, from market discovery through feature definition, roadmap prioritization, and delivery, while leveraging deep domain expertise in tax audit management and notice response workflows to build a differentiated, AI-enabled product experience. Own the Roadmap: Own end-to-end product development lifecycle to translate complex problems into streamlined AI workflows expressed as well-defined features with clear requirements and acceptance criteria; Balance quick-win AI capability launch with robust, long-term value drivers. Ensure Enterprise AI Trust & Accuracy: Implement rigorous evaluation frameworks to ensure AI-generated insights and responses maintain a 0% tolerance for critical compliance errors. Champion the User Experience: Work closely with UX design to build automation and intuitive, human-in-the-loop interfaces that allow corporate tax professionals to review, verify, and approve AI actions with absolute confidence. Partner on Go-to-Market initiatives: Collaborate with Product Marketing, Sales, and Customer Success to define pricing, packaging, ongoing support to ensure adoption and customer satisfaction Own Subject Matter Expertise: Apply deep knowledge of tax audits, audit management and notice response workflows to shape product requirements; understand the types of questions auditors ask, the data and evidence required to respond, and the processes organizations use to gather, organize, and present audit responses. Define the AI-First Vision: Establish the multi-year product strategy for a modern, data-driven AI-first solution to improve audit notice response, evidence gathering, and workflow automation; shape requirements and drive AI capabilities from concept to delivery including model training cycles, and benchmark evaluations Adopt Customer-first mindset: Engage directly with customers to understand audit management pain points, validate product direction, and ensure the solution delivers measurable value across the notice response lifecycle. Required Qualifications Hands-on experience with tax audit management and notice response workflows, including experience as an auditor responsible for audit notice response, or in a role directly managing the evidence-gathering and response process; must demonstrate familiarity with what auditors ask for and how organizations assemble and present evidence in response to audits. Strong customer-facing skills with experience engaging customers in discovery, validation, and strategic discussions; ability to understand and empathize with customer pain points and translate them into product decisions. Experience using cloud-based tools and software platforms to gather, organize, and manage audit evidence data Proven Product management experience with a demonstrated ability to own a product or product area independently, including strategy, roadmap, feature definition, requirements and acceptance criteria, and backlog prioritization. Proven ability to translate complex audit and compliance workflows into clear, implementable product requirements for Engineering and cross-functional teams. Proven ability to drive cross-functional initiatives across Product, Engineering, Sales, Marketing, and Consulting without direct reporting authority. Preferred Qualifications Prior experience working at or with an audit management software platform, risk management solution, or compliance technology vendor. Background in tax technology, indirect tax, transaction tax, or financial compliance domains. Experience at a Big Four professional services firm (Deloitte, PwC, EY, or KPMG) in an audit, tax, or advisory capacity. Familiarity with AI-enabled audit automation, evidence-gathering workflows, or notice response technologies. Bachelor's degree in Business, Accounting, Finance, Engineering, or a related field; equivalent combination of education, training, and relevant professional experience accepted in lieu of a formal degree. COMMENTS: The above statements are intended to describe the general nature and level of work being performed by individuals in this position. Other functions may be assigned, and management retains the right to add or change the duties at any time. Vertex Values: Together We Win We're building a team of people who are passionate about making an impact for our customers and committed to how that impact is achieved. Our values define the behaviors, mindset, and culture that make Vertex a great place to grow and do meaningful work. Play to Win or We Don't Play — If we choose to do something, we're choosing to do it because we plan to win. That mindset raises our bar on product quality, customer outcomes, and how we show up for one another. Work As a Team, Putting the Customer At the Core — Our customers are our true north. Whatever your role, ask: how will this help a customer succeed today? We earn trust through outcomes, not promises. Achieve Excellence With Integrity, Speed, and Agility — The market isn't slowing down. We'll move faster, adapt quickly, and never compromise on doing things the right way — for teammates, customers, and partners. Innovate Boldly With a Growth Mindset — Progress demands smart risk. We'll try new approaches, learn fast, and keep pushing the boundaries — especially where AI can remove friction and unlock value. Communicate with Care, Candor and Transparency — Honest, constructive conversations make us better. Let's speak plainly about what's working and what isn't and help each other improve. Pay Transparency Statement: US Base Salary Range: $191,500.00 - $249,000.00 Base pay offered to new hires may vary based upon factors including relevant industry and job-related skills and experience, geographic location, and business needs.* The range displayed does not encompass the full potential of the role, which allows for further growth and career progression. In addition, as a part of our total compensation package, this role may be eligible for the Vertex Bonus Plan (VOB), a role-specific sales commission/bonus, and/or equity grants. Learn more about Life at Vertex and connect with your recruiter for more details regarding Vertex's compensation and benefit programs. *In no case will your pay fall below applicable local minimum wage requirements.

Build healthcare-professional relationships and execute territory plans to increase awareness and adoption of JOURNAVX in the acute pain market. | Requires a bachelor's degree and at least five years of biotech sales experience, preferably including acute-pain product launches, plus willingness to travel up to 80%. | Job Description General Summary: The Pain Territory Business Manager (TBM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor of NaV1.8 in acute pain. The TBM reports into a Regional Field Leader and serves as a field representative for JOURNAVX within the community setting. The TBM will work closely with Pain Territory Account Managers (PTAMs) who are also field-based reps within the geographic area who serve as account managers within hospitals/health systems and are responsible for driving and pulling through hospitals/health system volume and access as well as targeted physicians within their hospital networks. Key Responsibilities: Establishes meaningful and professional relationships with assigned physicians with the goal of building awareness and driving adoption of JOURNAVX. Develops and maintains expertise on the product’s clinical attributes and patient unmet need and educates healthcare professionals on product use in appropriate patients. Develops a deep understanding of assigned physicians, territory & market dynamics, stakeholder mapping, key decision maker relationship management, patient protocols, referral network navigation, access, and drivers & barriers. Implements and maintains strategic territory business plans that identify and harness business opportunities and patient-focused solutions for significant growth across the customer landscape while supporting the PTAM led account engagement strategy within hospital settings. Drives sales performance and ensures forecasts and assigned budgets meet or exceed territory expectations. Collaborates compliantly with other field team members (e.g., PTAMs, field medical, HEOR, IDN and Payer Account teams) and headquarter colleagues to create aligned business plans, focus on strategic drivers, share best practices, and inform initiatives. Role models ethics and integrity in the work that you do to support our culture of compliance and earn trust with external stakeholders, particularly in the context of this market and its history. Required Experience and Knowledge/Skills: 5+ experience in biotech sales; product launch experience is highly desired Product launch experience in acute pain and successfully engaging with diverse physicians is highly desired. Experience effectively engaging with retail pharmacies to ensure stocking and managed care pull through. Experience with pulling through the implementation of inpatient formularies, protocols, pathways, and order sets. Ability to understand the nuances of patient treatment in the geography, including but not limited to care coordination, patient referral patterns, and influence networks. Highly competent in a multitude of IT capabilities to support the business needs including Veeva CRM. Experience working in a highly matrixed environment. Bachelor’s degree Other Requirements Employee will be required to establish certain customer credentials and requirements, which include, but may not be limited to, successful completion of trainings, background screens, drug testing and vaccinations. Must live and work within the territory. Depending on the territory’s geography and work requirements may also be required to live within a reasonable distance to a major airport. Valid driver’s license and in good standing. Travel by car or airplane up to 80% of the time and work after hours as required by business needs. 10-30% of overnight travel may be required depending on territory. Pay Range: $140,000 - $160,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an incentive bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $120,000 - $180,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Lead clinical and commercial product logistics, manage temperature-controlled shipments and logistics providers, and develop compliant supply-chain strategies and improvements. | Requires 7–10+ years in pharmaceutical supply chain, logistics, or manufacturing leadership, including cold-chain, global logistics, and GDP experience; a postgraduate degree is preferred. | Job Description General Summary: The Associate Director of Logistics Operations is responsible for management and execution of all Small Molecule & Biologics product distribution and product movement logistics in support of product delivery. This includes establishing, championing, and implementing end to end management of clinical/development and commercial shipments with real-time tracking and troubleshooting of issues. This person will manage Temperature Controlled logistics shipments, 3PL management, carrier management, import/export compliance and product distribution. The role works closely with couriers, Clinical Operations, CMO scheduling staff, QA and other stakeholders to plan and execute product movement logistics. The Associate Director is integral to the success of the clinical and commercial programs at Vertex. Key Duties and Responsibilities: Plays a key role in the commercialization strategy for small molecule [CF & Pain] and biologics including processes and technological requirements. Management of all site-to-site materials movement including, but not limited to API, Start Material, SDD, DS, DP and other materials involved on manufacturing / testing / release of Clinical and/or Commercial products across the network (Internal / External / 3PL / etc.) Accountable for establishing programs/partnerships and supporting sourcing & selection activities of global 3PLs that can be used by the business to deliver outsourced services for warehousing, transport and international logistics. Supports development and execution of logistics network strategy supporting product launches and life-cycle management, in alignment with Vertex’s corporate strategy. Oversees Logistics Service Provider (LSP) performance, including: relationship management, service/performance, audit and qualification, RFI/RFP’s, continuous improvement and support of contract related activities (i.e. CDA, MSA, SOW, Rate Card, etc.). Develop continuous improvement plans for Vertex’s Logistics infrastructure.* Assist in the identification and implementation of continuous improvement opportunities and customer satisfaction opportunities. Identify, initiate, and manage cross-functional logistics projects using appropriate project management expertise and methodologies. Manage the operational aspects of on-going projects and serve as liaison between project management, project team, Quality, and line management. Oversee LSP’s trade management activities and enforce corporate compliance as it pertains to the transportation of goods domestically and internationally, including troubleshoot of trade related issues. Represent and contribute on behalf of the Global Logistics functions when the organization engages in strategic projects, business ventures or seeks to expand into emerging and new markets; seeks to rationalize, review or invest in technology platforms that affect the logistics organization directly or indirectly. Facilitate cross-functional team collaborations as well as support executive leadership and stakeholders within the business in developing business strategies, inclusive of long-term goals and objectives. Knowledge and Skills: Excellent communication and interpersonal skills with the ability to communicate complex issues and solutions enterprise-wide. Excellent team player who is able to build and sustain respect and trust at all levels of the organization. Ability to anticipate adverse scenarios and provide contingency plans to address them. Sound judgment and business acumen with personal versatility and flexibility as the business and team evolves. Direct experience with managing logistics and temperature control / cold chain operations. Proven supervisory experience and demonstrated ability to develop direct reports. Has familiarity with managing Logistics with a network of both internal and external (CDMO)manufacturing sites. Has an excellent understanding of Good Distribution Practices in the Pharmaceutical Industry. Has a working knowledge of Trade Compliance requirements. Has knowledge of Logistics systems such as TMS, WMS and system / carrier integrations. Demonstrated ability to successfully plan and optimize all resources of a group or function(budgets, staff, technology, succession planning, etc.) for advancement of all goals and objectives. Demonstrated ability to work effectively in a collaborative and fast-paced team environment, including business leadership to build alignment. Ability to influence others in sensitive or difficult situations. Ability to think critically and demonstrate troubleshooting and problem-solving skills. Ability to function efficiently and independently in a changing environment. Familiarity with various regulations including those related to hazardous shipments, employee safety, and freight classifications. In depth experience in Microsoft Excel (tables, arrays, formulas, conditional formatting). Education and Experience: 7-10+ years progressive experience in Supply Chain, Logistics and/or manufacturing leadership roles in the pharmaceutical industry – Experience with Biological products and Genetic and Cell Therapy technologies is strongly preferred. Master’s degree in business or supply chain or industrial engineering or finance preferred. Experience in building and managing complex Global Supply Chain Logistics operations and Network Design principles. Thought leader in Logistics, Warehousing and Transportation with a proven ability to innovate and implement practical, compliant solutions. Proven ability to work seamlessly across teams and develop excellent partnerships with peers. Demonstrated understanding of the principles and regulations associated with GDP operations. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $150,500 - $225,700 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Remote-Eligible Flex Eligibility Status: In this Remote-Eligible role, you can choose to be designated as: 1. Remote: work remotely five days per week and come into the office on occasion – you’re always welcome on-site; or select 2. Hybrid: work remotely up to two days per week; or select 3. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Remote Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Manage temperature-controlled logistics processes ensuring compliance, quality, and operational excellence across global supply chain and manufacturing networks. | Requires 5-7+ years in pharmaceutical logistics or quality roles, strong cold-chain expertise, regulatory compliance knowledge, and leadership skills. | Job Description General Summary: The Manager, Temperature Controlled Logistics (TCL) is responsible for supporting the development, implementation, and continuous improvement of processes and procedures that enable reliable, compliant temperature-controlled logistics operations across Vertex. This role partners closely with Logistics Operations teams across all modalities, Logistics Service Providers, Quality Assurance, Packaging Engineering, Supply Chain, Technical Operations, Trade Compliance, Sourcing & Procurement, and internal and external manufacturing organizations to ensure product quality, regulatory compliance, and evolving business needs are consistently met. The successful candidate will help design, build, and sustain a robust logistics network that supports pipeline and commercial programs. Key responsibilities include evaluating and deploying innovative active and passive packaging solutions; assessing IoT-enabled monitoring devices and temperature data loggers; and evaluating vendor systems and data capabilities to enable real-time monitoring of shipment integrity and temperature conditions. The Manager will also oversee logistics quality-system activities, including change controls, from initiation through closure. This position requires a collaborative, data-driven leader with a strong quality and compliance mindset, deep cold-chain logistics expertise, and the ability to anticipate, troubleshoot, and resolve complex operational issues in a fast-paced environment. Key Duties and Responsibilities: • Develop, implement, and maintain standard operating procedures, work instructions, and packaging instructions that enable compliant logistics activities across the Global Supply Chain and Internal and External manufacturing network, in alignment with Logistics Service Providers. • Ensure temperature-controlled logistics processes consistently support product quality, regulatory requirements, and business objectives. Serve as the primary point of contact for shipping and validation activities during Health Authority inspections and internal audits. • Manage logistics related quality system activities, including deviations, corrective and preventive actions, after-action reviews, and associated remediation activities. • Own the development and maintenance of Logistics Validation Master Plans supporting the validation of shipping and storage activities across modalities and product types throughout the product lifecycle, from clinical development through commercial operations. • Partner with Product and Program Teams to support product launches, lifecycle-management activities, and evolving temperature-controlled logistics requirements. • Support supplier qualification, transportation lane selection, risk assessments, and transportation mode decisions for temperature-controlled shipments, including the selection of qualified active and passive packaging solutions. • Own the periodic review and maintenance of the internal Logistics Risk Assessment tool, including lane and route data, in close partnership with Logistics Operations teams and Logistics Service Providers. • Collaborate with Logistics Operations, DTE, Quality, and other cross-functional stakeholders to evaluate, implement, launch, and continuously enhance logistics and supply chain information systems. • Define, measure, analyze, and communicate temperature-controlled logistics key performance indicators and supporting metrics to assess logistics and distribution performance and identify improvement opportunities. • Participate in quality exception investigations and lead the resolution of complex cold-chain and logistics issues, including implementation of remediation and preventive measures. • Lead process redesign workshops, manage process changes, and identify opportunities to improve operational performance, compliance, and scalability. • Facilitate cross-functional process workshops to gather requirements, align stakeholders, and translate business needs into sustainable, scalable process improvements. • Champion change management activities by educating stakeholders and supporting business users responsible for operating logistics processes, newly implemented capabilities, and temperature-controlled solutions. • Establish work plans and prioritize activities for external workforce resources and third party companies supporting shipping validation studies. Ensure work is delivered in accordance with internal policies and procedures, required timelines, and approved budgets. • Support the development and coordination of statements of work for applicable subcontracted services and monitor invoices for related activities. Knowledge and Skills: • Bachelor’s degree in relevant discipline • 5-7+ years progressive experience in Engineering, Quality and/or Manufacturing roles in the pharmaceutical industry – Experience with Clinical/Commercial drug, device and/or combination products across Biologics and Genetic and Cell Therapy technologies. • Master’s degree in business or supply chain or industrial engineering or finance preferred. • Experience in leading development and implementation of packaging solutions used in logistics activities across complex logistics operations. • Thought leader in Logistics, Warehousing and Transportation with a proven ability to innovate and implement practical, compliant solutions. • Proven ability to work seamlessly across teams and develop excellent partnerships with peers. • Demonstrated experience of the principles and regulations associated with GDP / GxP compliance. Education and Experience: • Direct experience managing temperature-controlled and cold-chain logistics for small-molecule, cell therapy, and gene therapy programs, including short-lead-time operations. • Experience managing logistics across internal manufacturing sites, external manufacturing partners, and CDMOs. • Strong knowledge of Good Distribution Practices, trade-compliance requirements, and regulations related to hazardous shipments, employee safety, and freight classifications. • Working knowledge of logistics technology and data integrations, including Transportation Management Systems, Warehouse Management Systems, and carrier integrations. • Strong analytical and data-driven approach to evaluating performance, identifying risks, and developing practical solutions. • Advanced Microsoft Excel skills, including tables, arrays, formulas, and conditional formatting. • Demonstrated ability to anticipate operational risks, develop effective contingency plans, and resolve complex logistics issues through critical thinking and creative problem-solving. • Excellent written, verbal, interpersonal, and presentation skills, with the ability to communicate complex issues and solutions effectively across the organization. • Proven ability to build trusted relationships, influence stakeholders, and create alignment across cross-functional teams and all organizational levels. • Strong organizational, time-management, and prioritization skills, with the ability to work independently and effectively in a collaborative, fast-paced, and evolving environment. • Sound business judgment, flexibility, and the ability to manage change while maintaining focus on quality, compliance, and operational performance. • Demonstrated supervisory and resource-management capabilities, including the ability to develop team members and optimize budgets, staffing, technology, and other resources to achieve business objectives. • Professional certifications and membership in Professional Associations (APICS CLTD, CSCP) is strongly preferred. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $111,800 - $167,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Remote-Eligible Flex Eligibility Status: In this Remote-Eligible role, you can choose to be designated as: 1. Remote: work remotely five days per week and come into the office on occasion – you’re always welcome on-site; or select 2. Hybrid: work remotely up to two days per week; or select 3. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Remote Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Manage and improve temperature-controlled logistics operations ensuring compliance, quality, and operational performance across supply chain and manufacturing networks. | Requires 5-7+ years in engineering, quality, or manufacturing in pharma logistics with strong cold-chain expertise, leadership skills, and compliance knowledge. | Job Description General Summary: The Manager, Temperature Controlled Logistics (TCL) is responsible for supporting the development, implementation, and continuous improvement of processes and procedures that enable reliable, compliant temperature-controlled logistics operations across Vertex. This role partners closely with Logistics Operations teams across all modalities, Logistics Service Providers, Quality Assurance, Packaging Engineering, Supply Chain, Technical Operations, Trade Compliance, Sourcing & Procurement, and internal and external manufacturing organizations to ensure product quality, regulatory compliance, and evolving business needs are consistently met. The successful candidate will help design, build, and sustain a robust logistics network that supports pipeline and commercial programs. Key responsibilities include evaluating and deploying innovative active and passive packaging solutions; assessing IoT-enabled monitoring devices and temperature data loggers; and evaluating vendor systems and data capabilities to enable real-time monitoring of shipment integrity and temperature conditions. The Manager will also oversee logistics quality-system activities, including change controls, from initiation through closure. This position requires a collaborative, data-driven leader with a strong quality and compliance mindset, deep cold-chain logistics expertise, and the ability to anticipate, troubleshoot, and resolve complex operational issues in a fast-paced environment. Key Duties and Responsibilities: • Develop, implement, and maintain standard operating procedures, work instructions, and packaging instructions that enable compliant logistics activities across the Global Supply Chain and Internal and External manufacturing network, in alignment with Logistics Service Providers. • Ensure temperature-controlled logistics processes consistently support product quality, regulatory requirements, and business objectives. Serve as the primary point of contact for shipping and validation activities during Health Authority inspections and internal audits. • Manage logistics related quality system activities, including deviations, corrective and preventive actions, after-action reviews, and associated remediation activities. • Own the development and maintenance of Logistics Validation Master Plans supporting the validation of shipping and storage activities across modalities and product types throughout the product lifecycle, from clinical development through commercial operations. • Partner with Product and Program Teams to support product launches, lifecycle-management activities, and evolving temperature-controlled logistics requirements. • Support supplier qualification, transportation lane selection, risk assessments, and transportation mode decisions for temperature-controlled shipments, including the selection of qualified active and passive packaging solutions. • Own the periodic review and maintenance of the internal Logistics Risk Assessment tool, including lane and route data, in close partnership with Logistics Operations teams and Logistics Service Providers. • Collaborate with Logistics Operations, DTE, Quality, and other cross-functional stakeholders to evaluate, implement, launch, and continuously enhance logistics and supply chain information systems. • Define, measure, analyze, and communicate temperature-controlled logistics key performance indicators and supporting metrics to assess logistics and distribution performance and identify improvement opportunities. • Participate in quality exception investigations and lead the resolution of complex cold-chain and logistics issues, including implementation of remediation and preventive measures. • Lead process redesign workshops, manage process changes, and identify opportunities to improve operational performance, compliance, and scalability. • Facilitate cross-functional process workshops to gather requirements, align stakeholders, and translate business needs into sustainable, scalable process improvements. • Champion change management activities by educating stakeholders and supporting business users responsible for operating logistics processes, newly implemented capabilities, and temperature-controlled solutions. • Establish work plans and prioritize activities for external workforce resources and third party companies supporting shipping validation studies. Ensure work is delivered in accordance with internal policies and procedures, required timelines, and approved budgets. • Support the development and coordination of statements of work for applicable subcontracted services and monitor invoices for related activities. Knowledge and Skills: • Bachelor’s degree in relevant discipline • 5-7+ years progressive experience in Engineering, Quality and/or Manufacturing roles in the pharmaceutical industry – Experience with Clinical/Commercial drug, device and/or combination products across Biologics and Genetic and Cell Therapy technologies. • Master’s degree in business or supply chain or industrial engineering or finance preferred. • Experience in leading development and implementation of packaging solutions used in logistics activities across complex logistics operations. • Thought leader in Logistics, Warehousing and Transportation with a proven ability to innovate and implement practical, compliant solutions. • Proven ability to work seamlessly across teams and develop excellent partnerships with peers. • Demonstrated experience of the principles and regulations associated with GDP / GxP compliance. Education and Experience: • Direct experience managing temperature-controlled and cold-chain logistics for small-molecule, cell therapy, and gene therapy programs, including short-lead-time operations. • Experience managing logistics across internal manufacturing sites, external manufacturing partners, and CDMOs. • Strong knowledge of Good Distribution Practices, trade-compliance requirements, and regulations related to hazardous shipments, employee safety, and freight classifications. • Working knowledge of logistics technology and data integrations, including Transportation Management Systems, Warehouse Management Systems, and carrier integrations. • Strong analytical and data-driven approach to evaluating performance, identifying risks, and developing practical solutions. • Advanced Microsoft Excel skills, including tables, arrays, formulas, and conditional formatting. • Demonstrated ability to anticipate operational risks, develop effective contingency plans, and resolve complex logistics issues through critical thinking and creative problem-solving. • Excellent written, verbal, interpersonal, and presentation skills, with the ability to communicate complex issues and solutions effectively across the organization. • Proven ability to build trusted relationships, influence stakeholders, and create alignment across cross-functional teams and all organizational levels. • Strong organizational, time-management, and prioritization skills, with the ability to work independently and effectively in a collaborative, fast-paced, and evolving environment. • Sound business judgment, flexibility, and the ability to manage change while maintaining focus on quality, compliance, and operational performance. • Demonstrated supervisory and resource-management capabilities, including the ability to develop team members and optimize budgets, staffing, technology, and other resources to achieve business objectives. • Professional certifications and membership in Professional Associations (APICS CLTD, CSCP) is strongly preferred. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $111,800 - $167,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Remote-Eligible Flex Eligibility Status: In this Remote-Eligible role, you can choose to be designated as: 1. Remote: work remotely five days per week and come into the office on occasion – you’re always welcome on-site; or select 2. Hybrid: work remotely up to two days per week; or select 3. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Remote Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Provide specialized administrative support to senior leadership including calendar management, travel logistics, and meeting coordination. | Requires high school education and five years of relevant experience with advanced Microsoft Office skills and strong organizational and communication abilities. | Job Description General Summary: The Executive Assistant provides specialized, independent administrative/business support to 2-3 Vice Presidents supporting multi- therapeutic areas. Key Duties and Responsibilities: Serves as the primary support professional for a Sr. Vice President, independently handling a full range administrative activities As the delegate for the executive, handles details of a highly confidential and critical nature related to the function/department Interacts regularly with senior leaders inside and outside the Company in coordinating the affairs of the executive Manages the executive's complex and detailed calendar, frequently coordinating logistics and sharing information with other assistants and leaders both internally and externally; coordinates complex travel and meetings logistics, anticipating and resolving any problems to ensure a seamless experience for the executive Manages own workload, reprioritizing as unanticipated situations arise; assists the executive to adjust schedules to meet new and changing deadlines Produces high-quality documentation and contributes to building efficient processes and systems for administrative activities. Independently prioritizes and addresses requests for appointments, emails and telephone calls based on the needs and objectives for the executive Maintains high level of confidentiality of information related to the organization and staff Coordinates activities between departments and or outside parties As delegated by the executive, follows up with stakeholders at all levels to gather needed information, prompts/reminds them of critical deadlines, and helps remove any administrative roadblocks that prevent them from meeting their obligations to the executive Prepares meeting materials, including meeting agenda preparation/distribution, collecting/printing meeting pre-reads, minute- or note-taking and assembling/editing PowerPoint presentations Processes group purchase orders, invoices, and contracts Assists with visitor registration, including pre-registering and escorting visitors Assists with onboarding of new personnel into the department Provides guidance and training to less experienced colleagues Applies knowledge of business/department priorities to anticipate the executive's needs and drive administrative process improvements Builds collaborative and productive relationships across the organization and at all levels Knowledge and Skills: Advanced knowledge of Microsoft Office products Advanced time management and organizational skills, with a proven ability to independently prioritize own work and multi-task to meet changing or competing timelines High attention to detail Advanced verbal and written communication skills Exceptional interpersonal skills, especially with senior executives Ability to handle highly confidential and sensitive information Education and Experience: Typically requires high school or secondary school education Typically requires 5 years of experience, or the equivalent combination of education and experience Pay Range: $89,600 - $134,400 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com