Vertex Inc.

Lead UX engineering strategy and frontend architecture for AI platform, designing scalable interfaces and collaborating cross-functionally. | Bachelor's degree and proven frontend or UX engineering experience with strong proficiency in modern frameworks and interaction design. | Job Description Principal Engineer, VaiDA User Experience Location: Hybrid / On-site Vertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. At Vertex, we combine cutting-edge science, technology, and human-centered thinking to solve complex challenges and improve lives. Our digital and AI initiatives help empower employees across the organization with scalable, intuitive tools that accelerate innovation and decision-making. Role Summary Vertex Pharmaceuticals is seeking a Principal User Experience Engineer to shape the future of VaiDA, our enterprise AI platform for employees across Vertex. This role will design and build polished, seamless interfaces for sophisticated AI and multi-agent workflows used by employees across Vertex. The ideal candidate blends strong frontend engineering expertise with exceptional UX and product instincts, translating complex backend capabilities into user experiences that are clear, intuitive, and scalable for 10,000+ employees. This is a foundational role focused on ensuring VaiDA is not only powerful, but also approachable, efficient, and trusted to use. Key Responsibilities • Design and build high-quality frontend experiences for VaiDA and related AI-driven enterprise workflows • Lead UX engineering strategy and frontend architecture for VaiDA • Own interaction design and prototyping for a wide spectrum of user journeys and multi-agent experiences • Translate sophisticated technical capabilities into clear, intuitive, and scalable interfaces • Create workflow visualizations that improve usability, clarity, and user confidence • Partner closely with product, engineering, AI, and business stakeholders to define user-centered solutions • Develop and refine reusable UI patterns, components, and design standards for enterprise-scale applications • Prototype and validate concepts quickly to inform product direction and implementation • Advocate for usability best practices and help raise the bar for design quality across digital products • Contribute to the overall product vision for VaiDA as a trusted and engaging enterprise AI experience • Mentor engineers and influence UX engineering best practices across teams Required Qualifications • Bachelor’s degree in Computer Science, Human-Computer Interaction, Design, Engineering, or a related field; or equivalent practical experience • Proven experience in frontend engineering, product design engineering, or UX engineering roles • Strong track record of designing and building polished, user-centered interfaces for complex applications • Experience translating technical or data-rich workflows into clear and intuitive user experiences • Demonstrated ability to own interaction design and prototyping from concept through implementation • Strong understanding of usability, accessibility, and responsive design principles • Experience collaborating cross-functionally with product managers, engineers, and stakeholders • Ability to balance user needs, technical constraints, and business goals in a fast-paced environment • Excellent communication, problem-solving, and presentation skills Technical Skills Required • Modern frontend development frameworks such as React, Angular, TypeScript, JavaScript, HTML, and CSS • Interaction design and frontend prototyping • Enterprise UI development and scalable design systems • Experience with design tools such as Figma or similar prototyping platforms • Workflow visualization and complex interface design • Usability and human-centered design practices • Frontend performance optimization • Component-based architecture and reusable UI patterns • Collaboration with backend and AI/agent-based systems • Accessibility standards and inclusive design implementation Preferred Skills • Experience designing for AI-powered products, conversational interfaces, or multi-agent systems • Experience leveraging AI-assisted tools to accelerate frontend prototyping, design exploration, or development workflows • Familiarity with enterprise software and internal platform experiences • Understanding of product strategy and user research methods • Experience building interfaces for data-heavy, workflow-oriented, or highly technical applications • Familiarity with design systems governance and frontend architecture at scale Benefits Vertex offers a competitive and comprehensive rewards package designed to support employees professionally and personally, which may include: • Competitive salary and performance-based incentives • Comprehensive health, dental, and vision coverage • Retirement and savings programs • Paid time off and company holidays • Professional development and career growth opportunities • Inclusive and collaborative work environment • Employee wellness and support programs • The opportunity to help shape innovative AI experiences that make a meaningful impact across Vertex #LI-HYBRID Pay Range: $166,640 - $250,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Design and productionize multi-step AI agent workflows integrating enterprise systems and collaborate cross-functionally to refine agent behavior. | Bachelor's degree and hands-on experience building large language model or agentic system applications with ability to move from prototype to production balancing speed, quality, and security. | Job Description Position Summary Vertex is seeking an Agent Engineer, Agentic AI Platform to help create the next generation of AI agents that deliver practical value across internal and user-facing experiences. This role will focus on prototyping, building, and productionizing multi-step agent workflows that are deeply integrated with enterprise systems, business processes, and digital products. The ideal candidate is energized by fast-moving AI technology but grounded in strong engineering discipline. This individual will use a forward deployed engineering mindset to work closely with stakeholders, rapidly iterate on real-world use cases, connect agents to APIs and business systems, and continuously improve quality through measurement and feedback. The Agent Engineer will play an important role in shaping how AI agents are adopted and used day to day across Vertex. Key Responsibilities Design, prototype, and productionize AI agents and multi-step agent workflows for internal and user-facing use cases Apply a forward deployed engineering approach by working closely with end users, product teams, and business stakeholders to solve real workflow problems quickly and effectively Build agents that can reason across steps, invoke tools, call APIs, retrieve information, and take actions within defined enterprise guardrails Integrate agents with internal platforms, third-party applications, enterprise APIs, and business-critical systems Develop reusable agent patterns, components, prompts, tools, and orchestration logic that can be scaled across use cases Rapidly iterate on agent behavior based on usage data, qualitative feedback, evaluation results, and operational metrics Improve agent quality through testing, experimentation, benchmarking, and structured measurement of outcomes Partner with platform, integration, data, security, and product teams to ensure agents are secure, reliable, maintainable, and aligned with enterprise architecture Help define best practices for agent design, tool use, fallback behavior, escalation paths, and human-in-the-loop workflows Support deployment, monitoring, troubleshooting, and optimization of agents in production environments Contribute to observability practices for agent execution, including logging, tracing, performance tracking, and issue analysis Ensure solutions are designed with security, compliance, and responsible AI principles in mind Stay current on emerging patterns, frameworks, and technologies in generative AI and agentic systems, and translate them into practical applications for Vertex Required Qualifications Bachelor’s degree in Computer Science, Software Engineering, Artificial Intelligence, Data Science, or a related technical field; equivalent practical experience may be considered Experience in software engineering, AI engineering, machine learning engineering, or intelligent application development Hands-on experience building applications powered by large language models, AI workflows, or agentic systems Experience integrating software applications with APIs, data sources, and enterprise systems Demonstrated experience using AI-assisted software development and autonomous coding agents to design, generate, test, review, debug, optimize, and refactor code across complex enterprise systems. Deep understanding of AI-native software engineering practices and experience establishing standards, governance, and best practices for the responsible use of AI coding assistants and software engineering agents across engineering teams Demonstrated ability to move from prototype to production while balancing speed, quality, and operational rigor Experience working directly with users or stakeholders to iteratively refine technical solutions based on real-world needs Strong problem-solving and systems-thinking skills Strong written and verbal communication skills with the ability to work effectively across technical and non-technical teams Technical Skills Required Large language model application development Agentic workflow design and orchestration Prompt engineering and prompt iteration Tool use and API integration for AI agents Multi-step workflow automation Rapid prototyping and productionization Evaluation, testing, and quality measurement for AI systems Application logging, monitoring, and observability Distributed systems and service integration Secure software development practices Enterprise application integration Cloud-based application development Version control, CI/CD, and deployment practices Preferred Skills Experience using a forward deployed engineering or similar embedded delivery model Experience building internal copilots, assistants, or task-oriented AI agents Familiarity with orchestration frameworks, agent runtimes, tool-calling architectures, and retrieval patterns Experience integrating with enterprise collaboration tools, workflow systems, document platforms, or knowledge repositories Familiarity with evaluation frameworks for AI quality, groundedness, task completion, and reliability Experience designing human-in-the-loop workflows and safe failure or escalation mechanisms Exposure to AI observability, tracing, and operational analytics Experience in regulated industries such as biotechnology, pharmaceuticals, healthcare, or life sciences #LI-HYBRID Pay Range: $166,640 - $250,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Design and productionize multi-step AI agent workflows integrating enterprise systems while ensuring security and reliability. | Bachelor's degree and hands-on experience building applications with large language models or agentic systems, including API integration and moving prototypes to production. | Job Description Position Summary Vertex is seeking an Agent Engineer, Agentic AI Platform to help create the next generation of AI agents that deliver practical value across internal and user-facing experiences. This role will focus on prototyping, building, and productionizing multi-step agent workflows that are deeply integrated with enterprise systems, business processes, and digital products. The ideal candidate is energized by fast-moving AI technology but grounded in strong engineering discipline. This individual will use a forward deployed engineering mindset to work closely with stakeholders, rapidly iterate on real-world use cases, connect agents to APIs and business systems, and continuously improve quality through measurement and feedback. The Agent Engineer will play an important role in shaping how AI agents are adopted and used day to day across Vertex. Key Responsibilities Design, prototype, and productionize AI agents and multi-step agent workflows for internal and user-facing use cases Apply a forward deployed engineering approach by working closely with end users, product teams, and business stakeholders to solve real workflow problems quickly and effectively Build agents that can reason across steps, invoke tools, call APIs, retrieve information, and take actions within defined enterprise guardrails Integrate agents with internal platforms, third-party applications, enterprise APIs, and business-critical systems Develop reusable agent patterns, components, prompts, tools, and orchestration logic that can be scaled across use cases Rapidly iterate on agent behavior based on usage data, qualitative feedback, evaluation results, and operational metrics Improve agent quality through testing, experimentation, benchmarking, and structured measurement of outcomes Partner with platform, integration, data, security, and product teams to ensure agents are secure, reliable, maintainable, and aligned with enterprise architecture Help define best practices for agent design, tool use, fallback behavior, escalation paths, and human-in-the-loop workflows Support deployment, monitoring, troubleshooting, and optimization of agents in production environments Contribute to observability practices for agent execution, including logging, tracing, performance tracking, and issue analysis Ensure solutions are designed with security, compliance, and responsible AI principles in mind Stay current on emerging patterns, frameworks, and technologies in generative AI and agentic systems, and translate them into practical applications for Vertex Required Qualifications Bachelor’s degree in Computer Science, Software Engineering, Artificial Intelligence, Data Science, or a related technical field; equivalent practical experience may be considered Experience in software engineering, AI engineering, machine learning engineering, or intelligent application development Hands-on experience building applications powered by large language models, AI workflows, or agentic systems Experience integrating software applications with APIs, data sources, and enterprise systems Demonstrated experience using AI-assisted software development and autonomous coding agents to design, generate, test, review, debug, optimize, and refactor code across complex enterprise systems. Deep understanding of AI-native software engineering practices and experience establishing standards, governance, and best practices for the responsible use of AI coding assistants and software engineering agents across engineering teams Demonstrated ability to move from prototype to production while balancing speed, quality, and operational rigor Experience working directly with users or stakeholders to iteratively refine technical solutions based on real-world needs Strong problem-solving and systems-thinking skills Strong written and verbal communication skills with the ability to work effectively across technical and non-technical teams Technical Skills Required Large language model application development Agentic workflow design and orchestration Prompt engineering and prompt iteration Tool use and API integration for AI agents Multi-step workflow automation Rapid prototyping and productionization Evaluation, testing, and quality measurement for AI systems Application logging, monitoring, and observability Distributed systems and service integration Secure software development practices Enterprise application integration Cloud-based application development Version control, CI/CD, and deployment practices Preferred Skills Experience using a forward deployed engineering or similar embedded delivery model Experience building internal copilots, assistants, or task-oriented AI agents Familiarity with orchestration frameworks, agent runtimes, tool-calling architectures, and retrieval patterns Experience integrating with enterprise collaboration tools, workflow systems, document platforms, or knowledge repositories Familiarity with evaluation frameworks for AI quality, groundedness, task completion, and reliability Experience designing human-in-the-loop workflows and safe failure or escalation mechanisms Exposure to AI observability, tracing, and operational analytics Experience in regulated industries such as biotechnology, pharmaceuticals, healthcare, or life sciences #LI-HYBRID Pay Range: $166,640 - $250,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Design and implement secure, scalable integrations between AI platform and enterprise systems. | Bachelor's degree and 8+ years in software engineering with expertise in API integrations and event-driven architectures. | Job Description Position Summary Vertex is seeking an Integrations Engineer, Agentic AI Platform to connect the AI/agentic platform to the systems, tools, and data sources that make AI valuable in real enterprise workflows. This role will focus on designing and implementing secure, scalable, and reliable integrations across internal platforms, third-party applications, and business-critical services. The ideal candidate brings strong expertise in MCP/A2A protocols, APIs, event-driven architectures, authentication patterns, and enterprise integration design. This individual will play a key role in ensuring AI capabilities are embedded into day-to-day work at Vertex and not as isolated proofs of concept, but as production-ready solutions integrated into the enterprise ecosystem. Key Responsibilities Design, build, and maintain integrations between the AI/agentic platform and enterprise systems, internal applications, third-party tools, and business services Implement secure, scalable connectivity patterns that enable AI agents and workflows to access data, trigger actions, and interact with enterprise platforms Develop and support integrations using MCP, A2A, APIs, webhooks, and event-driven architectures Create reusable connectors, middleware components, and service patterns that accelerate onboarding of new tools and systems into the AI platform Partner with platform, product, data, security, and enterprise application teams to ensure integrations meet technical, business, and compliance requirements Design robust authentication and authorization patterns for integrated AI services, including identity propagation, token handling, and access control Enable AI workflows to interact reliably with core enterprise platforms such as collaboration tools, knowledge systems, workflow tools, and line-of-business applications Support integration patterns for structured and unstructured data sources used by AI and agentic applications Implement monitoring, logging, tracing, error handling, and alerting for integration services and platform connectors Ensure integrations are resilient, maintainable, observable, and aligned with enterprise architecture standards Contribute to platform governance by defining integration standards, documentation, onboarding guidance, and best practices Troubleshoot and resolve issues related to connectivity, data exchange, authentication, latency, and downstream service dependencies Evaluate emerging standards and tools in AI system interoperability and enterprise integrations to inform platform evolution Required Qualifications Bachelor’s degree in Computer Science, Information Systems, Software Engineering, or a related technical field; equivalent practical experience may be considered 8+ years of experience in software engineering, platform engineering, or enterprise integrations Strong hands-on experience designing and implementing API-based integrations in enterprise environments Experience with MCP, A2A, service-to-service communication, or similar integration/interoperability patterns Strong understanding of event-driven architecture, messaging systems, asynchronous processing, and workflow-based integration design Experience with authentication and authorization standards such as OAuth, OIDC, SSO, service principals, secrets management, and token-based security Familiarity with enterprise application integration patterns, middleware, and distributed systems design Experience building secure, scalable, and reliable production services Strong problem-solving skills and ability to work across multiple systems, teams, and technical domains Strong written and verbal communication skills with the ability to document and explain integration approaches clearly Deep understanding of AI-native software engineering practices and experience establishing standards, governance, and best practices for the responsible use of AI coding assistants and software engineering agents across engineering teams Experience defining architecture, standards, and reusable services for large-scale enterprise environments Technical Skills Required MCP and A2A protocols REST APIs and service integration Webhooks and event-driven integration patterns Enterprise application integration Authentication and authorization design OAuth, OIDC, SSO, and token management Distributed systems and microservices Messaging and asynchronous processing Integration observability, logging, and monitoring Data exchange patterns across enterprise systems Secure connectivity and secrets management Cloud platforms and cloud-native integration architectures Error handling, resiliency, and performance optimization Versioning, testing, and deployment of integration services Preferred Skills Experience integrating AI or agentic platforms with enterprise tools and business systems Familiarity with workflow orchestration platforms and automation frameworks Experience building reusable connectors or SDKs for platform extensibility Knowledge of enterprise data platforms, document systems, knowledge repositories, and collaboration tools Experience with regulated environments such as biotechnology, pharmaceuticals, healthcare, or life sciences Exposure to AI platform patterns including tool use, agent execution, retrieval, and action frameworks Experience supporting platform governance, security reviews, and integration documentation Understanding of observability practices for complex, multi-system workflows #LI-HYBRID Pay Range: $166,640 - $250,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Design, build, and optimize software applications ensuring high code quality and system performance while collaborating with teams. | Bachelor's degree and at least one year of software development experience with proficiency in multiple programming languages. | Job Description General Summary: Responsible for designing, building, and optimizing software applications, ensuring code quality, and collaborating with teams to deliver high-quality solutions. Key Duties and Responsibilities: Design and develop software applications and systems. Implement software architecture and design patterns. Optimize software for performance, scalability, and reliability. Collaborate with cross-functional teams to deliver software solutions. Conduct code reviews and ensure adherence to best practices. Knowledge and Skills: Proficiency in multiple programming languages (e.g., Java, Python, C#, JavaScript). Expertise in software architecture and design patterns. Experience with Agile and DevOps practices. Strong understanding of database systems and data structures. Ability to work collaboratively with cross-functional teams. Education and Experience: Bachelor’s degree in Computer Science, Software Engineering, or related field. 1 year of experience in software development roles. Pay Range: $95,200 - $142,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Lead large-scale technical programs by translating business strategy into execution plans and managing governance and dependencies. | 10+ years leading complex technical programs in SaaS or enterprise software with strong systems thinking and executive communication. | Job Description: About the Role We are seeking a Senior Principal Technical Program Manager to lead one of Vertex's most strategic transformation programs: the Connected Tax Platform Experience (CTPE). This is not a traditional delivery coordination role. CTPE connects AI-driven tax workflows, shared platform capabilities, governance and trust controls, customer-facing experiences, and measurable business outcomes into a unified platform experience. As a Senior Principal TPM, you will serve as a system-level execution leader responsible for translating strategy into scalable execution across Product, Engineering, Architecture, Platform, UX, Data, Governance, and Operations. You will create clarity in ambiguous environments, align stakeholders around shared outcomes, surface risks before they become blockers, and provide leadership with trusted visibility into program health, readiness, and delivery confidence. Success in this role requires strong technical fluency, systems thinking, executive communication skills, and the ability to drive alignment across multiple organizations with competing priorities. You will help connect product intent to engineering execution, execution to release readiness, and release readiness to customer and business outcomes. Why This Role Matters This role offers the opportunity to influence one of Vertex's highest-priority strategic initiatives and help shape the future of Technical Program Management through AI-augmented workflows, signal-driven execution, modern governance practices, and outcome-focused delivery. Key Responsibilities Lead large-scale, cross-functional technical programs that span Product, Engineering, Platform, Architecture, UX, Data, Governance, and Operations. Translate business strategy and product vision into structured execution plans, milestones, dependencies, risks, decision frameworks, and measurable outcomes. Establish and maintain program operating mechanisms including roadmap management, dependency tracking, risk management, executive reporting, and release planning. Create clarity in ambiguous and rapidly evolving environments by identifying tradeoffs, structuring work, defining priorities, and enabling informed decisions. Drive alignment across multiple products, platforms, and workflow domains to achieve shared business and customer objectives. Partner with Product, Engineering, and Architecture leaders to connect roadmap priorities, technical dependencies, release readiness, and customer value realization. Establish governance practices using metrics, telemetry, readiness indicators, risk thresholds, and outcome-based measurements. Proactively identify execution risks, dependency gaps, governance concerns, and delivery bottlenecks while driving mitigation and escalation when necessary. Lead executive-level communications that provide clear visibility into progress, risks, confidence levels, tradeoffs, and business impact. Leverage AI-assisted workflows, automation, and scalable operating mechanisms to improve execution velocity, transparency, and delivery quality. Ensure customer-facing platform capabilities are delivered with appropriate technical, operational, and organizational readiness. Help evolve TPM practices that improve execution quality, visibility, and decision-making across complex enterprise programs. Required Qualifications 10+ years of experience leading large-scale technical programs within SaaS, cloud, platform, or enterprise software organizations. Proven success leading complex cross-functional initiatives involving multiple products, engineering organizations, platform teams, and executive stakeholders. Demonstrated ability to translate strategy into scalable execution through governance, planning, dependency management, risk mitigation, and measurable outcomes. Strong systems-thinking skills with the ability to connect strategy, technical execution, architecture, customer experience, and business impact. Experience partnering with Engineering and Architecture leaders to evaluate technical tradeoffs, platform dependencies, scalability considerations, and delivery sequencing. Strong technical acumen across cloud platforms, enterprise software, data platforms, distributed systems, workflow platforms, or AI-enabled products. Experience managing complex dependencies, risks, governance requirements, and executive decision points. Executive-level communication skills with the ability to create trusted narratives, decision frameworks, risk assessments, and outcome-based reporting. Demonstrated ability to influence senior leaders and drive alignment without relying solely on formal authority. Ability to operate effectively in ambiguity, create clarity without complete requirements, and drive progress across competing priorities. Experience delivering customer-facing product or platform capabilities through release, adoption, and operational readiness. Bachelor's degree in a technical, business, or related field, or equivalent practical experience. Preferred Qualifications Experience leading AI-first, automation, workflow transformation, data platform, or platform modernization initiatives. Experience within tax, compliance, fintech, ERP, e-invoicing, audit, or other regulated software environments. Experience delivering customer-facing platform experiences that span multiple products and shared technical foundations. Experience defining program metrics, release confidence frameworks, readiness models, governance mechanisms, or signal-driven operating structures. Experience using AI tools, automation, knowledge management, or workflow orchestration technologies to enhance execution effectiveness. Experience partnering with executive leadership on enterprise transformation programs or portfolio-scale initiatives. Experience coaching TPMs or developing scalable TPM operating models. Familiarity with Agile, Lean, SAFe, or similar delivery methodologies and the ability to apply them pragmatically. PMP, PgMP, cloud, AI, data, or related technical certifications are a plus. COMMENTS: The above statements are intended to describe the general nature and level of work being performed by individuals in this position. Other functions may be assigned, and management retains the right to add or change the duties at any time. Vertex Values: Together We Win We're building a team of people who are passionate about making an impact for our customers and committed to how that impact is achieved. Our values define the behaviors, mindset, and culture that make Vertex a great place to grow and do meaningful work. Play to Win or We Don't Play — If we choose to do something, we're choosing to do it because we plan to win. That mindset raises our bar on product quality, customer outcomes, and how we show up for one another. Work As a Team, Putting the Customer At the Core — Our customers are our true north. Whatever your role, ask: how will this help a customer succeed today? We earn trust through outcomes, not promises. Achieve Excellence With Integrity, Speed, and Agility — The market isn't slowing down. We'll move faster, adapt quickly, and never compromise on doing things the right way — for teammates, customers, and partners. Innovate Boldly With a Growth Mindset — Progress demands smart risk. We'll try new approaches, learn fast, and keep pushing the boundaries — especially where AI can remove friction and unlock value. Communicate with Care, Candor and Transparency — Honest, constructive conversations make us better. Let's speak plainly about what's working and what isn't and help each other improve. Pay Transparency Statement: US Base Salary Range: $191,500.00 - $249,000.00 Base pay offered to new hires may vary based upon factors including relevant industry and job-related skills and experience, geographic location, and business needs.* The range displayed does not encompass the full potential of the role, which allows for further growth and career progression. In addition, as a part of our total compensation package, this role may be eligible for the Vertex Bonus Plan (VOB), a role-specific sales commission/bonus, and/or equity grants. Learn more about Life at Vertex and connect with your recruiter for more details regarding Vertex's compensation and benefit programs. *In no case will your pay fall below applicable local minimum wage requirements.

Lead multiple projects and provide operational support for a commercial team including budget and stakeholder management. | Bachelor's degree and 6+ years experience in cross-functional project execution with strong critical thinking and detail orientation. | Job Description General Summary: The Project Management & Strategic Senior Manager is responsible for multiple department projects and provides centralized operational support for the U.S. Commercial team. By partnering with departmental management and cross-functional project teams, the Senior Manager develops and maintains integrated project plans and operational processes in accordance with project/department objectives, and are within budget. The Senior Manager is also responsible for comprehensive communication, including status reporting, risk management, and department processes to cross-functional stakeholders and department senior leaders. The Senior Manager partners closely with the Chief of Staff, U.S. Commercial to execute on strategic, operational, and organizational matters. Key Duties and Responsibilities: Leads multiple departmental projects and is responsible for departmental program/process operations Develops plans, goals, processes and logistics for projects, gaining cooperation and alignment Works closely with department leadership to continue to maximize process efficiency and align department goals and strategy Regularly interacts with functional areas beyond own department Conducts complex scenario planning to proactively provide analysis, make process improvement recommends on alternative development plans Effectively summarizes key information such as program progress, timeline updates, risk opportunity assessments and SOPs Develops and maintains project and departmental budgets and is accountable for understanding and communicating forecast variance, risks and opportunities Compiles succinct reports and prepares minutes for internal meetings; methodically tracks all actions items, and finds new ways to stay abreast of multi-dimensional tasks Contributes to the best practices of project management and departmental operations to support the continued success and evolution of the department Knowledge and Skills: Experience in cross-functional execution including medium to large-scale projects Critical thought partner and proven ability to connect people and ideas to drive outcomes Ability to connect with over divisions and functions throughout Vertex Self-motivated; acts independently and prioritizes appropriately; embraces unexpected changes or challenges and drives to improved solutions Ability to manage multiple priorities/projects at a given time, ensuring deadlines, budgets and status updates Developed communication skills and the ability to synthesize data and information into meaningful insights Very detail oriented and strong project/operation management skills Ability to handle ambiguity Education and Experience: Typically requires a bachelor's degree Typically requires 6 years of experience or the equivalent combination of education and experience Pay Range: $139,200 - $208,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Provide high-level administrative and business support to senior leaders including managing complex calendars and coordinating logistics. | Requires 6+ years administrative experience, proficiency in Microsoft Office, and strong organizational and communication skills. | Job Description General Summary: Vertex is seeking a highly organized, proactive, and experienced Senior Administrative Assistant to provide administrative support to the Legal & Compliance team. The Senior Administrative Assistant role provides specialized, independent administrative and business support to Senior Leaders. The ideal candidate brings exceptional judgment, professionalism, attention to detail, and the ability to independently manage multiple priorities. This individual will play a key role in supporting business operations, coordinating activities, collaborating across the department, and maintaining effective administrative processes in a fast-paced environment. Key Duties and Responsibilities: Serves as the primary support professional for Senior Leaders, handling a full range of administrative activities Manages calendars for assigned personnel, including meeting scheduling (both internal and off-site meetings), accepting/declining invites, meeting prioritization, securing conference rooms, ordering catering and "day-of" logistical and administrative support Serves as a departmental resource for Vertex's internal technologies (i.e; Procurement, SharePoint, Concur, Vertex U, VLearn, etc.) Exchanges and integrates information from stakeholders into departmental reports Books flights/hotels, completes expense reports, and arranges team lunches/dinners and offsite meetings for assigned personnel Based on established departmental procedures, prioritizes and addresses requests for appointments, e-mails and telephone calls; directly handles most requests but routes complex or unusual problems to more senior personnel Coordinates and helps prepare meeting materials, including meeting agenda preparation/distribution, collecting/printing meeting pre-reads, minute- or note-taking and assembling/editing PowerPoint presentations Processes group purchase orders, invoices, and contracts Assists with visitor registration, including pre-registering and escorting visitors Assists with the onboarding of new personnel into the department Oversees relevant local vendor relationships with office services providers such as cleaning companies, couriers, equipment technicians, mail/shipping services, etc. Operates with a high level of discretion and tact to protect the confidentiality of Vertex initiatives undertaken at the site/office Knowledge and Skills: Proficiency with Microsoft Office products Developed time management and organizational skills, with a proven ability to independently prioritize own work and multi-task to meet changing or competing timelines Attention to detail and quality of work product Strong verbal and written communication skills Strong interpersonal skills, especially with executives Strong collaboration and teamwork across functions and department Discretion to handle sensitive and confidential correspondence Education and Experience: Typically requires high school or secondary school education Typically requires 6+ years of experience, or the equivalent combination of education and experience #HYBRID #LI-MF1 Pay Range: $39 - $58 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Provide high-level administrative and logistical support including calendar, travel, and expense management, plus lead strategy and operations workstreams. | Bachelor's degree with 2-6 years of similar administrative experience, proficiency in Microsoft Office and Concur, and ability to manage confidential information and multiple projects. | Job Description Vertex currently operates at the forefront of scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF) patients. Our long-term commitment to advancing innovative therapies in other serious diseases continues to increase our need to grow and expand as an organization. Founded 30 years ago, Vertex has offices and research sites in North America, South America, and Europe. Vertex has consistently been recognized as one of the industry's top workplaces by leading publications such as Science Magazine, The Boston Globe, Boston Business Journal, San Diego Business Journal and The Scientist. The Global Pricing & Market Access (GPMA) team operates across the Vertex portfolio and works closely with partners across the globe to ensure payers recognize the value of Vertex medicines to enable Access to patients around the world. The Senior Administrative Assistant plays a key role on the GPMA team and directly supports the Vice President of Global Pricing & Market Access. In this capacity, the individual should excel at organization, management of multiple peoples' time and expectations, have a self-starter attitude and anticipate / proactively address challenges. The role includes multiple opportunities for ongoing skill and content development, as well as expanded opportunities for project management responsibilities. Key Responsibilities: Core day-to-day responsibilities: Provide logistical planning and administrative support for VP including calendar management, travel, expense reporting and document production Support GPMA leadership team with meeting management and travel and logistics as required and provide back-up support for other Commercial Sr. Administrative assistants Serve as the face for GPMA team while liaising with key internal and external customers Perform various supporting tasks such as creating/amending/formatting documents/presentations in Word, Excel or PowerPoint, printing, etc. Meetings & Events: Coordinate in-person, zoom meetings and conference calls with domestic and international participants; prepare meeting rooms & facilitate catering if required Manage meeting scheduling for multiple cross-functional, cross-regional forums that include participants VP and above (e.g. GPRC and Market Access Leadership Forum) Maintain cadence of key meetings including GPMA team meetings, Leadership Team meetings, 1:1s with direct reports, etc. Work with Human Resources to facilitate interview schedules for external candidates Travel & Expenses: Work with external parties including Concur to coordinate travel, hotel and related reservations for VP and Senior Directors on the team Handle all expenses for designated leadership in a timely fashion and per company policy/guidelines Purchasing & Budget: Manage the training of and overall procurement process for the team and liaise with related functions as required on behalf of GPMA Submit purchase orders, amendments and changes on behalf of the team working in partnership with CommContracts and iProcurement Expanded Strategy & Operations Responsibilities: Lead key S&O workstreams including management of annual GPMA business processes Business processes: Serve as key logistics contact for internal commercial planning processes (LRP, business planning, budget); Maintain GPMA calendar for deadlines and deliverables Serve as project manager for cross functional initiatives led by LT as required Build agenda for weekly team meetings (GPMA & LT) Agendas include rotation of project output sharing, guest speakers from other teams, roundtable, vendor / external capability presentations Schedule speakers, and send reminders ahead of their agenda topic Maintain materials on team’s site Support development of and logistics for annual team training and development plan Based on goals established by VP, source external/internal experts and co-develop curriculum for team development Coordinate logistics and ensure development plan fits into annual team calendar of other priorities and activities Lead development and administration of the Market Access Gateway (Sharepoint site for all Market Access / HEOR functions) Evolve site as required to meet function and business needs; ensure security Partner with DTE and content administrators Meetings & Events: Lead team annual off-site(s) with a focus on logistics and support of agenda / content to support meeting objectives Maintain materials on teams’ site Create and drive follow on workstreams generated from team off-sites as applicable Partner with GPMA lead and Meetings/Events Planning to plan/execute the annual Global Market Access Summit (~90 attendees) Collaborate with Vertex Meeting & Events on site selection, hotel contract, venue, and logistics to suit meeting needs and develop catering, logistics plan, etc. Coordinate with Creative agency on template, slide Q/A and other assets as needed with Meetings & Events Support relevant functions/regions to drive/coordinate content development to support meeting objectives Qualifications: Bachelor’s degree and 2-6 years of experience in a similar role Proficient in Microsoft Office suite, Outlook Calendar Management, and Concur Expense reporting systems Proven ability to prioritize effectively and successfully implement multiple projects on competing timelines Proven experience working in a fast-paced environment where multi-tasking is a part of doing business Excellent verbal and written communication skills Exceptional interpersonal skills, especially with senior executives, and experience across organizational functions Able to be trusted with highly confidential and sensitive information Team player with a track record of developing rapport and credibility with colleagues Detail oriented with the ability to proactively identify, communicate and address challenges Able to work independently on most aspects of projects Ability to clearly present project status and outline processes in oral and written formats Able to solve non-routine, complex issues in a proactive manner Consistently displays sound ethics, good judgment and demonstrates Vertex’s core values Pay Range: $39 - $58 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Lead large-scale SaaS technical programs by translating business strategy into execution and establishing governance for AI-driven platform delivery. | 10+ years leading large-scale SaaS technical programs with strong technical and executive communication skills. | Job Description: About the Role We are seeking a Senior Principal Technical Program Manager to lead one of Vertex's most strategic transformation programs: the Connected Tax Platform Experience (CTPE). This is not a traditional delivery coordination role. CTPE connects AI-driven tax workflows, shared platform capabilities, governance and trust controls, customer-facing experiences, and measurable business outcomes into a unified platform experience. As a Senior Principal TPM, you will serve as a system-level execution leader responsible for translating strategy into scalable execution across Product, Engineering, Architecture, Platform, UX, Data, Governance, and Operations. You will create clarity in ambiguous environments, align stakeholders around shared outcomes, surface risks before they become blockers, and provide leadership with trusted visibility into program health, readiness, and delivery confidence. Success in this role requires strong technical fluency, systems thinking, executive communication skills, and the ability to drive alignment across multiple organizations with competing priorities. You will help connect product intent to engineering execution, execution to release readiness, and release readiness to customer and business outcomes. Why This Role Matters This role offers the opportunity to influence one of Vertex's highest-priority strategic initiatives and help shape the future of Technical Program Management through AI-augmented workflows, signal-driven execution, modern governance practices, and outcome-focused delivery. Key Responsibilities Lead large-scale, cross-functional technical programs that span Product, Engineering, Platform, Architecture, UX, Data, Governance, and Operations. Translate business strategy and product vision into structured execution plans, milestones, dependencies, risks, decision frameworks, and measurable outcomes. Establish and maintain program operating mechanisms including roadmap management, dependency tracking, risk management, executive reporting, and release planning. Create clarity in ambiguous and rapidly evolving environments by identifying tradeoffs, structuring work, defining priorities, and enabling informed decisions. Drive alignment across multiple products, platforms, and workflow domains to achieve shared business and customer objectives. Partner with Product, Engineering, and Architecture leaders to connect roadmap priorities, technical dependencies, release readiness, and customer value realization. Establish governance practices using metrics, telemetry, readiness indicators, risk thresholds, and outcome-based measurements. Proactively identify execution risks, dependency gaps, governance concerns, and delivery bottlenecks while driving mitigation and escalation when necessary. Lead executive-level communications that provide clear visibility into progress, risks, confidence levels, tradeoffs, and business impact. Leverage AI-assisted workflows, automation, and scalable operating mechanisms to improve execution velocity, transparency, and delivery quality. Ensure customer-facing platform capabilities are delivered with appropriate technical, operational, and organizational readiness. Help evolve TPM practices that improve execution quality, visibility, and decision-making across complex enterprise programs. Required Qualifications 10+ years of experience leading large-scale technical programs within SaaS, cloud, platform, or enterprise software organizations. Proven success leading complex cross-functional initiatives involving multiple products, engineering organizations, platform teams, and executive stakeholders. Demonstrated ability to translate strategy into scalable execution through governance, planning, dependency management, risk mitigation, and measurable outcomes. Strong systems-thinking skills with the ability to connect strategy, technical execution, architecture, customer experience, and business impact. Experience partnering with Engineering and Architecture leaders to evaluate technical tradeoffs, platform dependencies, scalability considerations, and delivery sequencing. Strong technical acumen across cloud platforms, enterprise software, data platforms, distributed systems, workflow platforms, or AI-enabled products. Experience managing complex dependencies, risks, governance requirements, and executive decision points. Executive-level communication skills with the ability to create trusted narratives, decision frameworks, risk assessments, and outcome-based reporting. Demonstrated ability to influence senior leaders and drive alignment without relying solely on formal authority. Ability to operate effectively in ambiguity, create clarity without complete requirements, and drive progress across competing priorities. Experience delivering customer-facing product or platform capabilities through release, adoption, and operational readiness. Bachelor's degree in a technical, business, or related field, or equivalent practical experience. Preferred Qualifications Experience leading AI-first, automation, workflow transformation, data platform, or platform modernization initiatives. Experience within tax, compliance, fintech, ERP, e-invoicing, audit, or other regulated software environments. Experience delivering customer-facing platform experiences that span multiple products and shared technical foundations. Experience defining program metrics, release confidence frameworks, readiness models, governance mechanisms, or signal-driven operating structures. Experience using AI tools, automation, knowledge management, or workflow orchestration technologies to enhance execution effectiveness. Experience partnering with executive leadership on enterprise transformation programs or portfolio-scale initiatives. Experience coaching TPMs or developing scalable TPM operating models. Familiarity with Agile, Lean, SAFe, or similar delivery methodologies and the ability to apply them pragmatically. PMP, PgMP, cloud, AI, data, or related technical certifications are a plus. Pay Transparency Statement: US Base Salary Range: $191,500.00 - $249,000.00 Base pay offered to new hires may vary based upon factors including relevant industry and job-related skills and experience, geographic location, and business needs.* The range displayed does not encompass the full potential of the role, which allows for further growth and career progression. In addition, as a part of our total compensation package, this role may be eligible for the Vertex Bonus Plan (VOB), a role-specific sales commission/bonus, and/or equity grants. Learn more about Life at Vertex and connect with your recruiter for more details regarding Vertex's compensation and benefit programs. *In no case will your pay fall below applicable local minimum wage requirements. Join our Talent Community to stay updated on the latest job opportunities, news, and events tailored to your career interests. Vertex is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. If you'd like to view a copy of the company's affirmative action plan, please email AskHR@vertexinc.com. If you are an individual with a disability and would like to request a reasonable accommodation as part of the employment selection process, please contact 610-640-4200 or AskHR@vertexinc.com. This telephone line and email address is reserved solely for job seekers with disabilities requesting accessibility assistance or an accommodation in the job application process. Please do not call about the status of your job application if you do not require accessibility assistance or an accommodation. Messages left for other purposes, such as following up on an application or non-disability related technical issues, will not receive a response.

Manage security operating system, OKRs, KPIs, and drive cross-functional security program delivery with executive reporting. | 7+ years program management with 4+ years in information security or related fields, AI literacy, and cross-functional leadership in SaaS/cloud environments. | Job Description: We're hiring a Security Program Manager to serve as the operating backbone of the Office of the CISO. This is a senior individual contributor role for someone who thrives on connecting people, programs, and priorities across a complex enterprise and who uses AI tooling deliberately to multiply their impact. You'll partner directly with the CISO across all pillars of our security organization to drive security initiatives, OKRs, KPIs, and metrics into a single, coherent operating system. This is not a traditional project manager role. You'll own the full lifecycle of security programs—from intake and prioritization through execution and long-term operational health—and you'll succeed through influence, structure, and clarity rather than direct authority. You'll have a direct line to the CISO and immediate visibility across the enterprise. You'll shape how security operates, how it reports, and how it scales, including how the company governs AI as adoption accelerates. If you want to do the highest-leverage program management work of your career in security, this is it. Job Description Run the Security Operating System Own the operating cadence of the CISO function — weekly staff meetings, monthly program reviews, and quarterly business reviews. Produce the recurring decision-grade CISO report (executive summary, OKR scorecard, KPI scorecard, portfolio milestones, decisions required). Maintain a single portfolio view across all security programs — intake, approved, executing, complete — with clear stage gates, owners, and forecasts. Drive meeting preparation, documentation, stakeholder communication, and follow-through so leadership can focus on judgment calls, not coordination. Own the OKR, KPI, and Metrics System Run the quarterly OKR lifecycle across all four security teams — define, align, health check, and score. Ensure every Key Result has a baseline, target, owner, measurement method, and confidence level. Maintain a KPI dictionary with definitions, formulas, systems of record, thresholds, and cadence — covering posture KPIs, program delivery KPIs, and team execution KPIs. Ensure 100% of project work is mapped to an OKR or documented as run the business. Lead monthly trend analysis and tie outcomes back to security and business objectives. Drive Cross-Functional Program Delivery Own end-to-end delivery of security programs — risk management, vulnerability management, security awareness, product onboarding into security, M&A security execution, incident readiness, and compliance initiatives. Act as the primary liaison between Security and Engineering, IT, Product, Legal, Privacy, Finance, People, Sales, and Customer Success. Manage cross-team dependencies, and decision logs as drivers of action. Enforce escalation SLAs and stage gates with a small, senior, expert team. Build Executive & Board Communications Build recurring deliverables for executive leadership, audit committee, and board updates — executive summaries, slide content, speaker notes, and Q&A prep. Translate technical security and AI governance topics for non-technical executive audiences with clarity and brevity. Produce decision-grade options memos with root cause, tradeoffs, recommendation, owner, and deadline. Multiply Output Through Deliberate AI Use Use AI tooling (e.g., Microsoft 365 Copilot, Claude, ServiceNow AI) deliberately and daily — for status synthesis, dashboard refresh, meeting recaps, draft communications, evidence collection, and audit response prep. Identify and execute automation opportunities across security operations, GRC, and compliance workflows. Required Experience 7+ years of progressive program or portfolio management experience, with 4+ years dedicated to information security, GRC, or product security programs in a SaaS or cloud environment. Proven track record running OKR/KPI operating systems for security or technology leaders, including executive-ready reporting. Direct experience coordinating across GRC, Product/Application Security, Security Operations/Incident Response, and emerging AI security and governance functions. Demonstrated ability to operate as connective tissue across Engineering, Legal, Product, IT, Finance, and Sales — leading through influence rather than authority. Mastery of program management tooling — Jira, Confluence, ServiceNow, Smartsheet, PowerPoint, Excel/Power BI. Strong executive written and verbal communication; ability to produce concise, structured, dashboard-style one-pagers and decision memos. Comfortable enforcing operating discipline (cadences, stage gates, escalation SLAs) in a small, senior, expert team. Bias for action, ownership, and outcome — not activity. AI Literacy - Hands-on, deliberate daily use of AI tooling in your own workflows (drafting, synthesis, dashboards, evidence preparation, meeting recaps). - Understanding of AI security concerns: model risk, data leakage, prompt injection, third-party AI vendor risk, Shadow AI, AI guardrails, and Responsible AI principles. Preferred Certifications PMP, PgMP, or equivalent program management certification. CISSP, CISM, CRISC, or CISA (one strongly preferred). AI Governance certification (e.g., IAPP AIGP, ISO 42001 Lead Implementer). Other Qualifications The Winning Way behaviors that all Vertex employees need in order to meet the expectations of each other, our customers, and our partners. • Communicate with Clarity - Be clear, concise and actionable. Be relentlessly constructive. Seek and provide meaningful feedback. • Act with Urgency - Adopt an agile mentality - frequent iterations, improved speed, resilience. 80/20 rule – better is the enemy of done. Don’t spend hours when minutes are enough. • Work with Purpose - Exhibit a “We Can” mindset. Results outweigh effort. Everyone understands how their role contributes. Set aside personal objectives for team results. • Drive to Decision - Cut the swirl with defined deadlines and decision points. Be clear on individual accountability and decision authority. Guided by a commitment to and accountability for customer outcomes. • Own the Outcome - Defined milestones, commitments and intended results. Assess your work in context, if you’re unsure, ask. Demonstrate unwavering support for decisions. COMMENTS: The above statements are intended to describe the general nature and level of work being performed by individuals in this position. Other functions may be assigned, and management retains the right to add or change the duties at any time. Pay Transparency Statement: US Base Salary Range: $114,500.00 - $148,800.00 Base pay offered to new hires may vary based upon factors including relevant industry and job-related skills and experience, geographic location, and business needs.* The range displayed does not encompass the full potential of the role, which allows for further growth and career progression. In addition, as a part of our total compensation package, this role may be eligible for the Vertex Bonus Plan (VOB), a role-specific sales commission/bonus, and/or equity grants. Learn more about Life at Vertex and connect with your recruiter for more details regarding Vertex's compensation and benefit programs. *In no case will your pay fall below applicable local minimum wage requirements. Join our Talent Community to stay updated on the latest job opportunities, news, and events tailored to your career interests. Vertex is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. If you'd like to view a copy of the company's affirmative action plan, please email AskHR@vertexinc.com. If you are an individual with a disability and would like to request a reasonable accommodation as part of the employment selection process, please contact 610-640-4200 or AskHR@vertexinc.com. This telephone line and email address is reserved solely for job seekers with disabilities requesting accessibility assistance or an accommodation in the job application process. Please do not call about the status of your job application if you do not require accessibility assistance or an accommodation. Messages left for other purposes, such as following up on an application or non-disability related technical issues, will not receive a response.

Oversee security project portfolio, manage financials and governance, and lead project managers for delivery excellence. | Bachelor's degree and 10 years experience including 5 years in project/program/portfolio management with cybersecurity technology deployments and financial management. | Job Description General Summary Vertex’s Data, Technology and Engineering (DTE) organization is seeking a Technology Portfolio Management Director to join our Project Management and Strategic Operations (PMSO) team. Project Management and Strategic Operations is charged with streamlining and simplifying the work of our data and technology teams and ensuring the successful deployment of new technologies across our global enterprise. The Director, Information Security Technology Portfolio Management will report to our Senior Director of Project Management and Strategic Operations and partner directly with our Chief Information Security Officer to oversee the Information Security project portfolio of new technology implementations. The role requires portfolio planning, financial management, governance, and oversight of program, project and change management. The successful candidate will be a strategic thinker, demonstrate a deep understanding of portfolio, program and project management and expertise in the deployment of enterprise technologies for information security, data management, reporting and analytics. Key Duties and Responsiblities: Management of Information Security new technology implementation portfolio Maintaining technology roadmaps, ensuring alignment with strategic priorities, and resource and capacity management Developing and managing governance processes for technology implementations to ensure tight coupling to business requirements, executive sponsorship, and strategic priorities Co-developing communication decks for regular portfolio reviews and presentations to executive leadership Co-facilitating technology strategy and portfolio review meetings with senior leaders Influencing cross-functional stakeholders to ensure strategic thinking, sound decision-making, and proactive risk/ issue mitigation across the portfolio Managing, coaching, and training all project managers for Information Security Technology implementations to ensure excellence in project delivery Communicating portfolio status to DTE leadership and the Senior Director of Project Management and Strategic Operations to ensure cross-functional awareness and alignment Managing the portfolio financials including budget planning, forecasting and accruals Knowledge and Skills: Proven track record of successfully managing complex information technology projects, coordinating cross-functional teams, and delivering results within defined timelines and budgets Exceptional communication and presentation skills, with the ability to effectively communicate information security and data and software engineering technological concepts to both technical and non-technical audiences Strong leadership skills with the ability to influence and collaborate with stakeholders cross-functionally and at all levels of the organization Clear and succinct written and verbal communication is essential and fundamental to the role Strong, hands-on experience managing all financial components of project, program and portfolio planning and delivery, including budgeting, forecasting and accruals Proven ability to mentor, coach and motivate program and project managers in a way the enables collective success and development Education and Experience: Bachelor's degree or relevant experience Advanced degree with strong experience in biotechnology in an information technology setting preferred A minimum of 5 years of experience in project, program and/or portfolio management and exceptional organization and planning skills Experience in management of information security/cybersecurity technology deployments and operational activities Typically requires 10 years of experience or the equivalent combination of education and experience Pay Range: $185,600 - $278,400 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.

Lead product security strategy focusing on AI features, secure design, and risk management. | 5+ years in security with AI product security and cloud governance experience, proficient in OWASP and secure-by-design. | Job Description: Job Description Summary This role requires practical, hands-on AI fluency. The ideal candidate is comfortable operating directly within the product development lifecycle—understanding how modern AI systems and agents behave, improve over time, and fail—and applying that understanding to product security decisions, acceptance criteria, and release readiness while owning and evolving broader product security strategy, governance, and risk management practices across the organization. Own and evolve major components of the Product Security strategy, translating product and business risk into actionable, measurable security programs with clear success metrics. Lead Secure-by-Design initiatives across product teams, embedding security requirements early in product and feature design, and defining secure design patterns, reference architectures, and guardrails that scale. Lead security architecture reviews, secure code reviews, threat modeling, and application penetration testing, with a focus on systemic risk reduction across a broad range of products. Establish and own security best practices for AI-enabled product features, model integration, and AI service architectures, including data handling, model access, and inference workflows. Lead AI-specific threat modeling addressing misuse, data leakage, supply-chain exposure, and abuse scenarios; define security controls and governance requirements specific to AI features and services. Evaluate the security implications of new AI technologies, tools, and models prior to adoption; embed responsible AI principles—traceability, privacy, bias awareness, transparency, and auditability—into product security decisions. Drive consistency in how product and AI risks are assessed, documented, tracked, and accepted across the organization. Serve as advisor to product and engineering on security risk, architectural trade-offs, and risk acceptance decisions. Mentor and provide technical leadership to other Product Security engineers and serve as an escalation point for complex security decisions. Required Qualifications 5+ years of experience in the security domain, including applying security controls to cloud-based technologies and implementing Product Security frameworks such as OWASP, CIS Benchmarks, and Cloud Security Alliance (CSA). Proven track record of establishing security controls and governance requirements for AI-enabled features, including data handling, model access, and inference workflows. Hands-on experience with AI product development security, including partnering with engineering and subject matter experts on model evaluation, tuning, and training. Ability to define evaluation criteria for AI systems and interpret results to inform security requirements and release readiness decisions. Experience with cloud governance principles and Product Security tooling, including SAST and DAST. Demonstrated ability to lead threat modeling, secure code reviews, and application penetration testing for complex, cross-cutting security issues. Demonstrated expertise in defining and scaling secure design patterns, reference architectures, and security guardrails across multiple product teams. Technical acumen to experiment directly with AI tools and prototypes in support of faster product security validation. Preferred Qualifications Bachelor's degree in computer science or a related field; equivalent combination of education, training, and relevant professional experience accepted in lieu of a formal degree. Experience with DevSecOps practices, zero trust design principles, and cloud incident response. Experience contributing to the automation of security analysis and testing activities. Track record of mentoring and providing technical leadership to security engineering teams. Other Qualifications The Winning Way behaviors that all Vertex employees need in order to meet the expectations of each other, our customers, and our partners. • Communicate with Clarity - Be clear, concise and actionable. Be relentlessly constructive. Seek and provide meaningful feedback. • Act with Urgency - Adopt an agile mentality - frequent iterations, improved speed, resilience. 80/20 rule – better is the enemy of done. Don’t spend hours when minutes are enough. • Work with Purpose - Exhibit a “We Can” mindset. Results outweigh effort. Everyone understands how their role contributes. Set aside personal objectives for team results. • Drive to Decision - Cut the swirl with defined deadlines and decision points. Be clear on individual accountability and decision authority. Guided by a commitment to and accountability for customer outcomes. • Own the Outcome - Defined milestones, commitments and intended results. Assess your work in context, if you’re unsure, ask. Demonstrate unwavering support for decisions. COMMENTS: The above statements are intended to describe the general nature and level of work being performed by individuals in this position. Other functions may be assigned, and management retains the right to add or change the duties at any time. Pay Transparency Statement: Base pay offered to new hires may vary based upon factors including relevant industry and job-related skills and experience, geographic location, and business needs.* The range displayed does not encompass the full potential of the role, which allows for further growth and career progression. In addition, as a part of our total compensation package, this role may be eligible for the Vertex Bonus Plan (VOB), a role-specific sales commission/bonus, and/or equity grants. Learn more about Life at Vertex and connect with your recruiter for more details regarding Vertex's compensation and benefit programs. *In no case will your pay fall below applicable local minimum wage requirements. Join our Talent Community to stay updated on the latest job opportunities, news, and events tailored to your career interests. Vertex is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. If you'd like to view a copy of the company's affirmative action plan, please email AskHR@vertexinc.com. If you are an individual with a disability and would like to request a reasonable accommodation as part of the employment selection process, please contact 610-640-4200 or AskHR@vertexinc.com. This telephone line and email address is reserved solely for job seekers with disabilities requesting accessibility assistance or an accommodation in the job application process. Please do not call about the status of your job application if you do not require accessibility assistance or an accommodation. Messages left for other purposes, such as following up on an application or non-disability related technical issues, will not receive a response.