Rhythm Pharmaceuticals

Translate complex business questions into actionable insights, manage stakeholder priorities, and develop dashboards and reports for healthcare analytics. | Extensive experience with healthcare datasets, advanced SQL and Power BI skills, and familiarity with AI tools, with at least 6 years in pharma/healthcare analytics. | Company Overview Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together. Opportunity Overview The Senior Manager, Business Analytics & Reporting will serve as a trusted analytics partner to North America Region teams including Commercial, Patient Services, Market Access, and Medical Affairs—translating complex business questions into rigorous analyses and actionable insights. The individual will work closely with these functions to manage their unique and competing priorities with a sense of urgency, high level of responsiveness and independently delivering high quality work product including writing SQL queries, building automated dashboards, and creating executive-ready reports that drive daily decisions. This position reports into the Director, Advanced Analytics & Business Intelligence. Responsibilities and Duties Serve as an analytics bridge between teams—translating urgent business questions into rigorous, actionable analyses Manage competing stakeholder priorities, set realistic expectations, and deliver insights that shape daily decisions and quarterly strategy Build credibility by explaining what the data can and cannot answer, educating teams on methodology, and maintaining transparency about trade-offs Uncover the "why" behind performance trends Own recurring metrics that matter: Rx volume, patient flow, reimbursement approval rates, demand shipments, channel mix Support executive presentations for earnings calls, board meetings, and investor events—distilling complex analyses into clear visuals with actionable takeaways Write efficient SQL queries against Snowflake databases (claims, pharmacy feeds, CRM data) to extract and harmonize large commercial and patient datasets Design and automate Power BI dashboards that give real-time visibility into performance Use Python for exploratory analysis—testing hypotheses, identifying opportunities and risks, automating repetitive reporting Document your work and champion best practices in data quality, version control, and peer review Qualifications and Skills Bachelor's degree in Business Analytics, Statistics, Computer/Data Science, or related field (advanced degree preferred) 6+ years in pharma/healthcare analytics or BI, ideally with exposure to specialty pharmacy data, reimbursement dynamics, and rare-disease commercialization Experience working with large healthcare datasets such as claims, pharmacy adjudication feeds, or EMR data to understand patient journeys and real-world treatment patterns Advanced SQL proficiency (complex joins, window functions, query optimization) Expert-level Power BI or Tableau skills for dashboard development Strong Python capabilities for data wrangling and exploratory analysis (pandas, NumPy, scikit-learn, Plotly/Matplotlib) Comfort leveraging AI tools (e.g., ChatGPT, Claude, Copilot) to accelerate workflows—using LLMs for hypothesis generation, code review, documentation, and scenario testing while maintaining critical judgment on outputs Track record of managing multiple high-priority projects in fast-paced launch environments Ability to build trust with senior stakeholders, diplomatically negotiate priorities, and deliver difficult messages when needed This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel. The expected salary range for this position is $135,000 - $215,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units. More about Rhythm We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism. At Rhythm our core values are: We are committed to advancing scientific understanding to improve patients’ lives We are inspired to tackle tough challenges and have the courage to ask bold questions We are eager to learn and adapt We believe collaboration and ownership are foundational for our success We value the unique contribution each individual brings to furthering our mission Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law. Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.

Translate complex business questions into actionable insights, manage stakeholder priorities, and develop dashboards and reports for healthcare analytics. | Extensive experience with healthcare datasets, advanced SQL and Power BI skills, and familiarity with Python for data analysis, along with managing multiple projects in a fast-paced environment. | Company Overview Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together. Opportunity Overview The Senior Manager, Business Analytics & Reporting will serve as a trusted analytics partner to North America Region teams including Commercial, Patient Services, Market Access, and Medical Affairs—translating complex business questions into rigorous analyses and actionable insights. The individual will work closely with these functions to manage their unique and competing priorities with a sense of urgency, high level of responsiveness and independently delivering high quality work product including writing SQL queries, building automated dashboards, and creating executive-ready reports that drive daily decisions. This position reports into the Director, Advanced Analytics & Business Intelligence. Responsibilities and Duties Serve as an analytics bridge between teams—translating urgent business questions into rigorous, actionable analyses Manage competing stakeholder priorities, set realistic expectations, and deliver insights that shape daily decisions and quarterly strategy Build credibility by explaining what the data can and cannot answer, educating teams on methodology, and maintaining transparency about trade-offs Uncover the "why" behind performance trends Own recurring metrics that matter: Rx volume, patient flow, reimbursement approval rates, demand shipments, channel mix Support executive presentations for earnings calls, board meetings, and investor events—distilling complex analyses into clear visuals with actionable takeaways Write efficient SQL queries against Snowflake databases (claims, pharmacy feeds, CRM data) to extract and harmonize large commercial and patient datasets Design and automate Power BI dashboards that give real-time visibility into performance Use Python for exploratory analysis—testing hypotheses, identifying opportunities and risks, automating repetitive reporting Document your work and champion best practices in data quality, version control, and peer review Qualifications and Skills Bachelor's degree in Business Analytics, Statistics, Computer/Data Science, or related field (advanced degree preferred) 6+ years in pharma/healthcare analytics or BI, ideally with exposure to specialty pharmacy data, reimbursement dynamics, and rare-disease commercialization Experience working with large healthcare datasets such as claims, pharmacy adjudication feeds, or EMR data to understand patient journeys and real-world treatment patterns Advanced SQL proficiency (complex joins, window functions, query optimization) Expert-level Power BI or Tableau skills for dashboard development Strong Python capabilities for data wrangling and exploratory analysis (pandas, NumPy, scikit-learn, Plotly/Matplotlib) Comfort leveraging AI tools (e.g., ChatGPT, Claude, Copilot) to accelerate workflows—using LLMs for hypothesis generation, code review, documentation, and scenario testing while maintaining critical judgment on outputs Track record of managing multiple high-priority projects in fast-paced launch environments Ability to build trust with senior stakeholders, diplomatically negotiate priorities, and deliver difficult messages when needed This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel. The expected salary range for this position is $135,000 - $215,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units. More about Rhythm We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism. At Rhythm our core values are: We are committed to advancing scientific understanding to improve patients’ lives We are inspired to tackle tough challenges and have the courage to ask bold questions We are eager to learn and adapt We believe collaboration and ownership are foundational for our success We value the unique contribution each individual brings to furthering our mission Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law. Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.

Oversee data management activities, ensure quality and compliance, and lead process improvements in clinical data management. | Requires extensive experience in clinical data management, CRO oversight, and familiarity with GCP, ICH, and EDC systems, which are not reflected in your background. | Company Overview Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together. Opportunity Overview The Senior Manager, Data Management acts as the Lead Data Manager for multiple clinical studies and/or a clinical development program. The successful candidate will provide leadership and guidance for all phases of clinical studies from the EDC study design through to study closeout. They will be responsible for the oversight and management of clinical data management activities outsourced to CROs. The Senior Manager, Data Management will also contribute to the Rhythm data management operational improvement efforts to identify, develop, and implement departmental standards, applications, processes, and training. Responsibilities and Duties Responsible for the oversight of Clinical Data Management activities outsourced to CROs to ensure adherence to scope of work and service agreements Develop Data Management metrics and key performance indicators to aid in the oversight and management of CRO partners Responsible for CRO adherence to project timelines, from study startup through study closeout, ensuring high quality and integrity of all deliverables Collaborate with clinical study teams and vendors to ensure project deliverables are met, including data acquisition, quality data review and reporting in compliance with GCP, SOPs and regulatory requirements Review data via listings and visualization tools to report on performance and quality; review will be performed with clinical data within studies and across multiple studies for trend analysis Contribute to the development, review and implementation of Clinical Data Management processes, policies and SOPs Participate in vendor qualifications and audits Oversee the planning, execution, and maintenance of major projects and initiatives, if required. Lead data management study inspection readiness activities and the support of submission activities as needed. Train and mentor DM staff or members of the clinical trial team on processes, projects, systems, and programs. Perform hands-on data management responsibilities, if required. Qualifications and Skills Bachelor’s degree in a science-related discipline, or equivalent work experience 6+ years working in clinical data management at a Sponsor organization with experience across multiple indications and EDC platforms Experience developing initiatives designed to promote efficiency and productivity for data management operations Extensive knowledge of clinical data management outsourcing models including functional-service providers and full-service CROs Experience leading a team of CRO data managers to ensure the timely provision of DM deliverables Advanced hands-on knowledge of data management processes and EDC systems Knowledge of regulatory requirements (e.g. ICH, GCP, HIPAA) Experience with data visualization, analytics and reporting tools such as elluminate or SpotFire Strong project management skills, and ability to effectively lead and collaborate with various business functions Demonstrated ability of working on multiple projects simultaneously, independently managing competing priorities, and define tracking tools to manage projects Experience in solving extremely complex and increasingly difficult problems, independently taking the appropriate corrective action, and identify and implement improvements. Able to review, interpret and evaluate clinical data Demonstrate initiative, sound judgment and flexibility; possess effective time management and organizational skills; and be able to work under deadlines and on multiple projects simultaneously Excellent written and verbal communication skills, able to communicate effectively with senior management as well as with peers. Self-motivated, reliable team member CDASH experience Demonstrated ability to influence without authority Demonstrate initiative, sound judgment and flexibility Solid understanding of clinical drug development processes This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel. The expected salary range for this position is $135,000 - $215,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units. More about Rhythm We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism. At Rhythm our core values are: We are committed to advancing scientific understanding to improve patients’ lives We are inspired to tackle tough challenges and have the courage to ask bold questions We are eager to learn and adapt We believe collaboration and ownership are foundational for our success We value the unique contribution each individual brings to furthering our mission Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law. Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.

Manage and oversee clinical trial execution including CRO/vendor management, budgeting, regulatory compliance, and cross-functional coordination to ensure study deliverables. | 5+ years in clinical operations or related roles within CRO/pharma/biotech, experience with multinational Phase I-IV trials, regulatory knowledge, strong organizational and communication skills, and ability to travel. | Company Overview Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the care of people living with rare melanocortin-4 receptor (MC4R) pathway diseases. Working at Rhythm means that you are part of a team that’s passionate about transforming the lives of people living with hyperphagia (pathological, insatiable hunger) and severe obesity caused by rare MC4R pathway diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together. Opportunity Overview Rhythm seeks an experienced and highly motivated individuals to join its team in Boston, Massachusetts. Within the clinical operations group, there are multiple ongoing and planned studies designed to develop innovative therapies for people with rare neuroendocrine diseases. The position will be responsible for overseeing components of study execution and as such will routinely interact with the medical, translational research, regulatory, biostats and diagnostic groups to ensure deliverables are met. Responsibilities and Duties • Manage integrations of all clinical study activities leveraging internal and CRO resources, expertise and knowledge • Provide trial cost estimates and timelines as part of CDP development • Drive execution of clinical trials from protocol design to the final clinical study report for specified studies. • Effectively communicate with Key Opinion Leaders • Manage all aspects of CRO/vendor identification, request for proposal submission, CRO selection, and the day-to-day operational management activities of CROs • Oversight of study quality and GCP compliance • Assist in the development of contingency/risk management plans and associated mitigation strategies • Oversee and coordinate with document specialists regarding study files and Trial Master File (TMF) quality checks, including oversight of junior team members • Prepare budgets, timelines, and forecasts for assigned clinical studies • Interface with Finance, Program Management, Accounting, Supply Operations, Quality Assurance and Medical Affairs to align on deliverables and execute study activities • Provide a variance analysis of budget to actual and notify finance of projected cost over/under expenditure Qualifications and Skills • BA/BS degree, advanced degree preferred • 5+ years of relevant experience within a CRO, pharmaceutical, and/or biotech company • Experience working on Phase I - IV multinational clinical studies • Regulatory knowledge, including Good Clinical Practices (GCPs) • Knowledge of global clinical trial management in CRO outsourced environment • Exceptional organizational skills and ability to deal with competing priorities, also strong reasoning and problem-solving ability • Excellent communication skills (written and verbal) • Ability to assemble a plan and execute on the details • Proficient with MS Office Suite (Excel, Word and PowerPoint) and MS Project • Able to travel (annual average of 10 – 20%) This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel. More about Rhythm We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism. At Rhythm our core values are: • We are committed to advancing scientific understanding to improve patients’ lives • We are inspired to tackle tough challenges and have the courage to ask bold questions • We are eager to learn and adapt • We believe collaboration and ownership are foundational for our success • We value the unique contribution each individual brings to furthering our mission Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law. Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.