PicnicHealth

Own and develop production AI systems, lead engineering efforts, and mentor engineers to operationalize AI in clinical data workflows. | Over 7 years of software engineering experience, with at least 2 years managing engineers, experience with large-scale production AI systems, and building internal tools for regulated environments. | At PicnicHealth, we're building the future of non-interventional clinical research, powered by AI and centered on patients. Our mission is to make it radically easier, faster, and more affordable to perform clinical trials and get better treatments to patients. We're replacing the legacy, services-heavy model with a modern, AI-first approach that unlocks insights from rich, multi-modal data—from clinical notes and imaging to lab results—at scale. By engaging patients directly through our personal health assistant, PicnicAI, which meets them where they’re at and delights them along the way (with an industry leading NPS of 76), patients participate actively in the research they care about. PicnicHealth is already a trusted partner to 7 of the top 10 pharmaceutical companies. Our work spans 40+ disease areas and has supported over 60 peer-reviewed publications, including an FDA submission that incorporates PicnicHealth data. Founded in 2014, we’ve raised $100M+ from top investors like Amplify Partners, Felicis Ventures, B Capital Group, and Y Combinator. Our business running non-interventional studies more than doubled last year, and we’re growing even faster in 2026. We’re a team of doctors, patients, data nerds, engineers, and builders, reimagining how clinical research works — and we’re just getting started! The Opportunity We're hiring an Engineering Manager to own and evolve the production systems that operationalize AI across PicnicHealth's clinical data platform. This is a 50/50 hands-on technical leadership and people management role. You'll spend half your time writing production code alongside a team of 3 engineers, and you'll be directly accountable for how these systems perform in production. The Capture team builds the systems that turn AI from an assistant into the primary driver of clinical data workflows—retrieving medical records,, abstracting clinical data, and ensuring quality at scale. These are human-in-the-loop systems where AI does the heavy lifting and humans provide oversight, correction, and quality assurance. You'll build the systems that operationalize these AI capabilities: workflow orchestration, error and edge case surfacing, audit trails, and the interfaces that let clinical users understand, trust, and correct AI outputs. We believe speed and quality reinforce each other—even in a regulated environment. Fast iteration, tight feedback loops, and frequent shipping are how you build trust in AI-powered systems. You'll be expected to continuously improve how your team ships, including rethinking workflows as AI development agents reshape what's possible in engineering. What you’ll do: Write and ship production code weekly—you'll be in the codebase alongside your team Drive a culture of shipping speed and continuous improvement—identify bottlenecks, reduce cycle times, and treat fast iteration as the primary mechanism for achieving quality in a regulated environment Build internal tools that give clinical and operations users visibility into AI decision-making, with appropriate guardrails, permissions, and correction workflows Work closely with an embedded AI engineer who owns prediction model quality, while you own the production systems, user-facing workflows, and speed gains that depend on those predictions Lead incident response and postmortems for team-owned systems; ensure failures result in durable fixes, not patches Mentor 3 engineers through building together—pairing, code review, and architectural decisions made in the context of real work Establish and maintain system reliability standards: monitoring, alerting, and continuous improvement loops that catch problems before users do Our stack includes GCP, Kubernetes, PostgreSQL, BigQuery, Node.js, React, Hasura GraphQL, TypeScript, and dbt. What You’ll Bring: 7+ years of software engineering experience, including 2+ years managing engineers while staying deeply hands-on—you've continued to ship production code as a manager Owned production systems processing large volumes of unstructured or semi-structured data, with personal accountability for reliability and correctness Meaningful experience building and operating AI-powered systems in production—you understand what it takes to make AI work reliably at scale, not just call an API Built internal tools or platforms for non-technical or regulated users, with demonstrated sensitivity to trust, UX, and workflow fit Comfortable making high-stakes technical decisions with incomplete information—and accountable for the outcomes, including failures Operated in ambiguous environments where requirements evolve, tradeoffs are real, and you're expected to drive clarity rather than wait for it Strong opinions on system observability, debugging, and operational excellence A track record of integrating AI into your engineering practices and workflows—not just the product you build, but how you build it. You have a point of view on how AI development agents are changing software engineering and ideas for how to stay ahead of that curve at PicnicHealth. We expect all team members to be amazing in their roles and, ultimately, to move the PicnicHealth mission forward. What is clinical research and why will PicnicHealth win? Clinical research is the industry responsible for conducting studies to evaluate the effectiveness of drugs and treatments. Better trials lead to faster, more cost-effective drug development, ultimately resulting in more and improved treatments for patients. However, the process remains highly inefficient. Trials are a major bottleneck in drug development, and the promising advancements in biotech cannot translate to real patient impact unless clinical research becomes faster and more efficient The industry runs on outdated technology and manual processes. Research sites (hospitals, academic centers, doctors' offices) are overburdened and under-resourced. Contract research organizations (CROs), the organizations that traditionally run clinical trials for life sciences companies, typically throw hundreds-of-thousands of man-hours wrangling sites and cobbling together vendor software. PicnicHealth has built technology that uniquely positions us to run faster, cheaper, and more flexible studies while removing burden from sites: PicnicAI (trained on 350M+ clinician annotations over 100k+ patient records) is the only system that can effectively access and structure all participant EMR data trials need Our AI health assistant (NPS of 76 in 2024) guides participants through study activities and enables most to be done at home We're an integrated solution — virtual site, CRO, and software platform — with AI built in from the ground up, initially focusing on non-interventional research. The other perks & benefits you get when you work at PicnicHealth We pay competitive salaries. Everyone on the team is an owner: all full time employees get competitive equity. Target Base Salary Range: $200K - $230K The base salary PicnicHealth offers may vary depending upon the scope, complexity, and autonomy of the position and on the candidate’s job-related knowledge, skills, and experience. We’re a remote first company, with teammates spread across the US. We support in-person gatherings, including co-working spaces and multi-day onsites, to build connections and move forward strategic initiatives. Expect to travel 2-4 times a year. For our team members in the Bay Area, who prefer to work in person we can offer a hybrid set up to work from the SF office on a flexible schedule. You also get: Comprehensive benefits including above market Health, Dental, Vision Family friendly environment Flexible time off 401k plan Free PicnicHealth account Equipment and internet funds for home office set up Wellness Stipend PicnicHealth is committed to promoting an inclusive work environment free of discrimination and harassment. We value a diverse and balanced team where everyone can belong.

The Clinical Operations Associate will lead the operational execution of site-based research, including startup, regulatory submissions, and ongoing support for observational studies. They will also innovate and refine processes to enhance site engagement and operational efficiency. | Candidates should have over 5 years of clinical research operations experience, with at least 2 years in site-facing roles. A Bachelor's degree in life sciences or a related field is required, along with strong expertise in compliance and cross-functional coordination. | PicnicHealth is simplifying clinical research with AI, making it faster and cheaper to get new treatments to patients. We’re bringing a patient-centered, AI-first approach to a $100b market otherwise dominated by old-school, services-driven incumbents. We’re creating a streamlined operating system for clinical research, built on top of our AI for medical record data in trials and a personal health assistant that keeps patients engaged (NPS 76). Founded in 2014, PicnicHealth has raised over $100 million from investors including YC, Amplify Partners, Felicis Ventures and B Capital Group. Our business running observational studies more than doubled last year and we expect to grow even faster this year. We've gained real traction in a conservative industry: 12 of the top 20 pharma companies use PicnicHealth, we've got 60+ publications across 40 disease areas, and we just had our first FDA approval that included our data in the submission. The Opportunity At PicnicHealth, we’re transforming how real-world data powers research through technology and patient-centered design. As our Clinical Operations Associate, you’ll be the operational lead for site-based research—owning the day-to-day execution of startup, regulatory submissions, onboarding, and ongoing support across a portfolio of observational and low-interventional studies. At the same time, you’ll play a role in shaping and evolving how we work with sites, testing new approaches, and refining our playbooks as we grow. You’ll thrive if you’re excited to roll up your sleeves to get the work done while also helping us figure out better, tech-forward ways of doing it. What we’re looking for: We’re looking for a self-starter that thrives in a dynamic start-up environment where processes evolve rapidly and who can take full ownership of outcomes. You’re energized by navigating ambiguity in the complex world of observational research, and you know how to bring clarity for others while keeping projects moving. You balance speed with quality, delivering work that meets high standards even under tight timelines. You’re comfortable juggling multiple priorities, and you know when to zoom out to anticipate risks and when to dive into the details to unblock execution. Most of all, you bring a collaborative mindset -building trust with sites, sponsors, and teammates - while holding yourself accountable for results. Over the next 12 months, you will be focused on: Centralizing site operations: Build and own scalable workflows for site startup (CDA/feasibility surveys, selection, contracting, budgeting, and IRB submissions). Streamlining onboarding: Lead creation of training materials, scripts, SOPs, and study one-pagers; ensure every site understands objectives, ICFs, workflows, and the PicnicHealth platform. Regulatory execution: Manage IRB submissions, amendments, and continuing reviews; track documentation in eTMF; own compliance handoffs. Ongoing site management: Conduct monthly check-ins, oversee site payment processes, distribute newsletters, and ensure site and stakeholder engagement across the study lifecycle. Cross-functional coordination with influence: Collaborate with Project Managers, Recruitment Managers, Product, and Delivery Leadership to operationalize observational studies at scale. Study closeout: Lead final site communications, regulatory wrap-up, and offboarding to ensure timely, compliant closure. Drive innovation in site operations: Develop and test tech-forward approaches to site engagement, pushing creativity in how we deliver consistently and efficiently, with quality. Leverage AI in a historically low-tech space: Apply AI to site workflows in a part of the industry that has historically been underpowered by technology. You’ll be successful if you: Bring 5+ years of clinical research operations experience, with at least 2 years in site-facing roles (observational or non-interventional research strongly preferred). Have hands-on experience with site startup, regulatory/IRB submissions, and ongoing site management. Hold a Bachelor’s degree in life sciences, public health, nursing, or a related field Operate with high autonomy and minimal supervision while maintaining exceptional standards for quality and compliance, backed by strong expertise in Good Clinical Practice (GCP), HIPAA, and site compliance workflows. Are adept at cross-functional coordination across delivery, regulatory and quality, and product teams. Excel in fast-paced, scaling health-tech environments, with a mindset for building reusable playbooks and processes. Possess excellent written and verbal communication skills, with the ability to influence, adapt and build trust with sites, sponsors, and internal stakeholders. We expect all team members to be motivated to be amazing in their roles and, ultimately, to move the PicnicHealth mission forward. Why will PicnicHealth win in Clinical Research? Trials are a major bottleneck in drug development, and the promising advancements in biotech cannot achieve their full potential unless clinical research becomes more effective. The industry runs on outdated technology and manual processes. Research sites (hospitals, academic centers, doctors' offices) are a major bottleneck, and contract research organizations (CROs) spend most of their time wrangling sites and cobbling together vendor software. PicnicHealth has built technology that uniquely positions us to run faster, cheaper, and more flexible studies without requiring sites: PicnicAI (trained on 350M+ clinician annotations over 100k+ patient records) is the only system that can effectively access and structure all participant EMR data trials need Our AI health assistant (NPS of 66 in 2024) guides participants through study activities and enables most to be done at home We're an integrated solution — virtual site, CRO, and software platform — with AI built in from the ground up, initially focusing on observational research. The other perks & benefits you get when you work at PicnicHealth We pay competitive salaries. Everyone on the team is an owner: all full time employees get competitive equity. Target Base Salary Range: $100K -$130K The base salary PicnicHealth offers may vary depending upon the scope, complexity, and autonomy of the position and on the candidate’s job-related knowledge, skills, and experience. We’re a remote first company, with teammates spread across the US. We support in-person gatherings, including co-working spaces and multi-day onsites, to build connections and move forward strategic initiatives. Expect to travel 2-4 times a year. For our team members in the Bay Area, who prefer to work in person we can offer a hybrid set up to work from the SF office on a flexible schedule. You also get: Comprehensive benefits including above market Health, Dental, Vision Family friendly environment Flexible time off 401k plan Free PicnicHealth account Equipment and internet funds for home office set up Wellness Stipend PicnicHealth is committed to promoting an inclusive work environment free of discrimination and harassment. We value a diverse and balanced team where everyone can belong.