Helix

Productionize and scale AI/ML-assisted genomic data curation workflows while building secure, robust clinical software with scientists and product teams. | Requires a degree in a scientific field and significant software development experience, including Python, cloud platforms, and AI/ML agent systems. | Who We Are & What We Do  At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics.  What is special about this role? You'll bridge the gap between genomic variants and the clinical answers that help patients act on their DNA. You'll partner with scientists and product leaders to turn promising prototypes into production systems that scale. Your code will power how Helix automates gene and variant curation for real patients. We have openings for both Senior and Staff level Engineers. You may apply at either level, and we’ll consider your experience, qualifications and demonstrated scope when determining the right level. As a Senior/Staff Bioinformatics Engineer, Clinical Applications, you will: * Productionize curation workflows that support both classical and modern AI/ML approaches to variant classification. * Automate evidence integration from sources such as ClinVar, gnomAD, and PubMed. * Collaborate closely with scientists, product, and clinical stakeholders to ensure software solutions meet scientific and product requirements. * Direct AI coding agents to accelerate development of curation pipelines, applying engineering judgment to validate correctness, security, and architectural fit before deployment. * At Senior level, own defined projects end to end, make technical decisions within agreed priorities and architecture, and raise trade-offs that affect broader systems. * At Staff level, independently frame ambiguous problems, set technical direction, and make consequential architecture and prioritisation decisions across the product area. About you: * Bachelor's degree in Science or related field with 7+ years (Senior) or 9+ years (Staff) of professional software development experience. Or, a Master's or Ph.D. with 3+ years (Senior) or 5+ years (Staff) of professional software development experience. * Advanced proficiency in production-quality Python, relational databases, and cloud platforms such as AWS. * Experience productionizing and scaling AI/ML software, especially agentic systems built with frameworks such as LangChain or LangGraph. * Experience collaborating with scientists to integrate bioinformatics/NGS tools and databases into production workflows. * Strong judgment evaluating AI-generated code and pipeline logic for correctness, security, and maintainability before it reaches production. Pluses: * Experience in clinical genomics, such as ACMG guidelines, clinical diagnostics, or Human Phenotype Ontology (HPO) terms. * Experience developing regulated software, such as software as a medical device. * At Staff level, the role may have the opportunity to take on people leadership responsibilities. Experience mentoring or managing others, or an interest in developing as a people leader, is a plus. Expected Interview Process: 1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer  Expected Pay For This Role: There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity  * Expected Helix Base: $161,500 - $219,625 * Expected Helix Discretionary Annual Bonus: 15% of your annual salary * Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: * Comprehensive Health Insurance with Date of Hire eligibility  * Above average employer paid premium coverage  * 12 weeks Helix Paid Parental Leave option  * 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire * Comprehensive Well-Being Benefits  * Flexible PTO * Remote options for many roles and a home office stipend  What To Expect During Your First 90 days: * First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. * Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.  * Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice [https://www.helix.com/privacy-policy]. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.  #LI-Remote

Lead technical direction and architecture for the Experience platform, drive complex projects, and mentor engineers. | 10+ years software engineering experience with full-stack expertise, cloud infrastructure knowledge, AI adoption experience, and leadership skills. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. What is special about this role? The Helix Experience Team builds the software platform and user experiences that guide patients and providers through their entire genetics journey, from enrollment through results delivery. As a Staff Software Engineer, you will set the technical direction for this platform and shape engineering standards across the organization. As a Staff Software Engineer - Experience, You Will • Guide and define the strategic technical direction for the Experience platform and wider Engineering organization. • Shape how Helix Engineering utilizes AI and advance our AI development best practices. • Direct AI agents to automate entire engineering workflows, including codifying our prompt libraries and context frameworks. • Design, architect, and implement software systems for our genomic applications and services, with a focus on the patient and provider experience. • Drive complex, ambiguous projects from scoping to production with autonomy, owning the design, architecture and implementation strategy. • Collaborate and lead cross-functional work with product managers, designers, user experience researchers, scientists, and our business leaders to drive meaningful outcomes to the business. • Shape the engineering standards, delivery practices, and quality bars within all of Engineering. • Serve as a dedicated technical mentor, helping grow our next generation of technical leaders. • Champion durable solutions that eliminate entire categories of technical debt and raise reliability. About You • 10+ years of equivalent professional experience as a Software Engineer, with a track record of impact at scale. • A strong product engineering mindset, with technical decisions anchored in customer and business outcomes. • Operates with a high degree of autonomy, identifies problems before they're escalated and drives them to resolution proactively. • Experience implementing and a passion for driving AI adoption in engineering workflows, with a proven ability to build automated safeguards and evaluations that validate AI-generated code at scale. • Proficiency with distributed systems built on cloud infrastructure such as AWS, GCP, or Azure. • Deep full-stack expertise, proficient in a backend language such as Go, Java, Python, Scala, or Rust. • Familiarity and experience developing and maintaining SPA’s on frameworks such as React, Next.js, Vue.js or similar using TypeScript/JavaScript. • A track record of raising the technical standards and practices of engineers beyond your immediate team or department. • Adaptable in a fast-paced startup environment where priorities may change quickly and frequently. Pluses • Bachelor’s or Master’s degree in Computer Science or a related field. • Familiarity with regulated software systems in any industry, such as HIPAA, ISO, or FDA. • Experience designing and architecting event-driven architectures. • Experience with AWS serverless infrastructure. • Experience in the life sciences, healthcare, or genomics domain. Expected Interview Process • Initial Screen 2) Technical Interviews 3) Leadership Interviews 4) Offer Expected Pay For This Role There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: • US: $173,000 - $234,500 USD • CA: $173,000 - $218,000 CAD • Expected Helix Discretionary Annual Bonus: 15% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your First 90 Days • First 5 days: You’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. • Day 5 - 30: You’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. • Day 30 - 90: You’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. Compensation The base pay range for this role is $173,000 – $234,500 per year.

Lead technical direction and architecture for the Experience platform, driving complex projects and mentoring engineers. | 10+ years software engineering experience with full-stack expertise, cloud infrastructure knowledge, and AI adoption experience. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. What is special about this role? The Helix Experience Team builds the software platform and user experiences that guide patients and providers through their entire genetics journey, from enrollment through results delivery. As a Staff Software Engineer, you will set the technical direction for this platform and shape engineering standards across the organization. As a Staff Software Engineer - Experience, You Will • Guide and define the strategic technical direction for the Experience platform and wider Engineering organization. • Shape how Helix Engineering utilizes AI and advance our AI development best practices. • Direct AI agents to automate entire engineering workflows, including codifying our prompt libraries and context frameworks. • Design, architect, and implement software systems for our genomic applications and services, with a focus on the patient and provider experience. • Drive complex, ambiguous projects from scoping to production with autonomy, owning the design, architecture and implementation strategy. • Collaborate and lead cross-functional work with product managers, designers, user experience researchers, scientists, and our business leaders to drive meaningful outcomes to the business. • Shape the engineering standards, delivery practices, and quality bars within all of Engineering. • Serve as a dedicated technical mentor, helping grow our next generation of technical leaders. • Champion durable solutions that eliminate entire categories of technical debt and raise reliability. About You • 10+ years of equivalent professional experience as a Software Engineer, with a track record of impact at scale. • A strong product engineering mindset, with technical decisions anchored in customer and business outcomes. • Operates with a high degree of autonomy, identifies problems before they're escalated and drives them to resolution proactively. • Experience implementing and a passion for driving AI adoption in engineering workflows, with a proven ability to build automated safeguards and evaluations that validate AI-generated code at scale. • Proficiency with distributed systems built on cloud infrastructure such as AWS, GCP, or Azure. • Deep full-stack expertise, proficient in a backend language such as Go, Java, Python, Scala, or Rust. • Familiarity and experience developing and maintaining SPA’s on frameworks such as React, Next.js, Vue.js or similar using TypeScript/JavaScript. • A track record of raising the technical standards and practices of engineers beyond your immediate team or department. • Adaptable in a fast-paced startup environment where priorities may change quickly and frequently. Pluses • Bachelor’s or Master’s degree in Computer Science or a related field. • Familiarity with regulated software systems in any industry, such as HIPAA, ISO, or FDA. • Experience designing and architecting event-driven architectures. • Experience with AWS serverless infrastructure. • Experience in the life sciences, healthcare, or genomics domain. Expected Interview Process • Initial Screen 2) Technical Interviews 3) Leadership Interviews 4) Offer Expected Pay For This Role There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: • US: $173,000 - $234,500 USD • CA: $173,000 - $218,000 CAD • Expected Helix Discretionary Annual Bonus: 15% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your First 90 Days • First 5 days: You’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. • Day 5 - 30: You’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. • Day 30 - 90: You’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. Compensation The base pay range for this role is $173,000 – $234,500 per year.

Lead technical direction, design and implement software systems, mentor engineers, and drive complex projects. | 10+ years software engineering experience, full-stack proficiency, cloud infrastructure knowledge, AI adoption experience, and leadership skills. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. What is special about this role? The Helix Experience Team builds the software platform and user experiences that guide patients and providers through their entire genetics journey, from enrollment through results delivery. As a Staff Software Engineer, you will set the technical direction for this platform and shape engineering standards across the organization. As a Staff Software Engineer - Experience, You Will • Guide and define the strategic technical direction for the Experience platform and wider Engineering organization. • Shape how Helix Engineering utilizes AI and advance our AI development best practices. • Direct AI agents to automate entire engineering workflows, including codifying our prompt libraries and context frameworks. • Design, architect, and implement software systems for our genomic applications and services, with a focus on the patient and provider experience. • Drive complex, ambiguous projects from scoping to production with autonomy, owning the design, architecture and implementation strategy. • Collaborate and lead cross-functional work with product managers, designers, user experience researchers, scientists, and our business leaders to drive meaningful outcomes to the business. • Shape the engineering standards, delivery practices, and quality bars within all of Engineering. • Serve as a dedicated technical mentor, helping grow our next generation of technical leaders. • Champion durable solutions that eliminate entire categories of technical debt and raise reliability. About You • 10+ years of equivalent professional experience as a Software Engineer, with a track record of impact at scale. • A strong product engineering mindset, with technical decisions anchored in customer and business outcomes. • Operates with a high degree of autonomy, identifies problems before they're escalated and drives them to resolution proactively. • Experience implementing and a passion for driving AI adoption in engineering workflows, with a proven ability to build automated safeguards and evaluations that validate AI-generated code at scale. • Proficiency with distributed systems built on cloud infrastructure such as AWS, GCP, or Azure. • Deep full-stack expertise, proficient in a backend language such as Go, Java, Python, Scala, or Rust. • Familiarity and experience developing and maintaining SPA’s on frameworks such as React, Next.js, Vue.js or similar using TypeScript/JavaScript. • A track record of raising the technical standards and practices of engineers beyond your immediate team or department. • Adaptable in a fast-paced startup environment where priorities may change quickly and frequently. Pluses • Bachelor’s or Master’s degree in Computer Science or a related field. • Familiarity with regulated software systems in any industry, such as HIPAA, ISO, or FDA. • Experience designing and architecting event-driven architectures. • Experience with AWS serverless infrastructure. • Experience in the life sciences, healthcare, or genomics domain. Expected Interview Process • Initial Screen 2) Technical Interviews 3) Leadership Interviews 4) Offer Expected Pay For This Role There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: • US: $173,000 - $234,500 USD • CA: $173,000 - $218,000 CAD • Expected Helix Discretionary Annual Bonus: 15% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your First 90 Days • First 5 days: You’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. • Day 5 - 30: You’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. • Day 30 - 90: You’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. Compensation The base pay range for this role is $173,000 – $234,500 per year.

Lead technical direction and architecture for the Experience platform, drive complex projects, mentor engineers, and integrate AI into engineering workflows. | 10+ years software engineering experience, strong full-stack skills, cloud infrastructure proficiency, AI workflow experience, and leadership in technical standards. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. What is special about this role? The Helix Experience Team builds the software platform and user experiences that guide patients and providers through their entire genetics journey, from enrollment through results delivery. As a Staff Software Engineer, you will set the technical direction for this platform and shape engineering standards across the organization. As a Staff Software Engineer - Experience, You Will • Guide and define the strategic technical direction for the Experience platform and wider Engineering organization. • Shape how Helix Engineering utilizes AI and advance our AI development best practices. • Direct AI agents to automate entire engineering workflows, including codifying our prompt libraries and context frameworks. • Design, architect, and implement software systems for our genomic applications and services, with a focus on the patient and provider experience. • Drive complex, ambiguous projects from scoping to production with autonomy, owning the design, architecture and implementation strategy. • Collaborate and lead cross-functional work with product managers, designers, user experience researchers, scientists, and our business leaders to drive meaningful outcomes to the business. • Shape the engineering standards, delivery practices, and quality bars within all of Engineering. • Serve as a dedicated technical mentor, helping grow our next generation of technical leaders. • Champion durable solutions that eliminate entire categories of technical debt and raise reliability. About You • 10+ years of equivalent professional experience as a Software Engineer, with a track record of impact at scale. • A strong product engineering mindset, with technical decisions anchored in customer and business outcomes. • Operates with a high degree of autonomy, identifies problems before they're escalated and drives them to resolution proactively. • Experience implementing and a passion for driving AI adoption in engineering workflows, with a proven ability to build automated safeguards and evaluations that validate AI-generated code at scale. • Proficiency with distributed systems built on cloud infrastructure such as AWS, GCP, or Azure. • Deep full-stack expertise, proficient in a backend language such as Go, Java, Python, Scala, or Rust. • Familiarity and experience developing and maintaining SPA’s on frameworks such as React, Next.js, Vue.js or similar using TypeScript/JavaScript. • A track record of raising the technical standards and practices of engineers beyond your immediate team or department. • Adaptable in a fast-paced startup environment where priorities may change quickly and frequently. Pluses • Bachelor’s or Master’s degree in Computer Science or a related field. • Familiarity with regulated software systems in any industry, such as HIPAA, ISO, or FDA. • Experience designing and architecting event-driven architectures. • Experience with AWS serverless infrastructure. • Experience in the life sciences, healthcare, or genomics domain. Expected Interview Process • Initial Screen 2) Technical Interviews 3) Leadership Interviews 4) Offer Expected Pay For This Role There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: • US: $173,000 - $234,500 USD • CA: $173,000 - $218,000 CAD • Expected Helix Discretionary Annual Bonus: 15% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your First 90 Days • First 5 days: You’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. • Day 5 - 30: You’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. • Day 30 - 90: You’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. Compensation The base pay range for this role is $173,000 – $234,500 per year.

Lead technical direction and architecture for the Experience platform, drive complex projects, and mentor engineers. | 10+ years software engineering experience with full-stack expertise, cloud infrastructure familiarity, and AI adoption in engineering workflows. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. What is special about this role? The Helix Experience Team builds the software platform and user experiences that guide patients and providers through their entire genetics journey, from enrollment through results delivery. As a Staff Software Engineer, you will set the technical direction for this platform and shape engineering standards across the organization. As a Staff Software Engineer - Experience, You Will • Guide and define the strategic technical direction for the Experience platform and wider Engineering organization. • Shape how Helix Engineering utilizes AI and advance our AI development best practices. • Direct AI agents to automate entire engineering workflows, including codifying our prompt libraries and context frameworks. • Design, architect, and implement software systems for our genomic applications and services, with a focus on the patient and provider experience. • Drive complex, ambiguous projects from scoping to production with autonomy, owning the design, architecture and implementation strategy. • Collaborate and lead cross-functional work with product managers, designers, user experience researchers, scientists, and our business leaders to drive meaningful outcomes to the business. • Shape the engineering standards, delivery practices, and quality bars within all of Engineering. • Serve as a dedicated technical mentor, helping grow our next generation of technical leaders. • Champion durable solutions that eliminate entire categories of technical debt and raise reliability. About You • 10+ years of equivalent professional experience as a Software Engineer, with a track record of impact at scale. • A strong product engineering mindset, with technical decisions anchored in customer and business outcomes. • Operates with a high degree of autonomy, identifies problems before they're escalated and drives them to resolution proactively. • Experience implementing and a passion for driving AI adoption in engineering workflows, with a proven ability to build automated safeguards and evaluations that validate AI-generated code at scale. • Proficiency with distributed systems built on cloud infrastructure such as AWS, GCP, or Azure. • Deep full-stack expertise, proficient in a backend language such as Go, Java, Python, Scala, or Rust. • Familiarity and experience developing and maintaining SPA’s on frameworks such as React, Next.js, Vue.js or similar using TypeScript/JavaScript. • A track record of raising the technical standards and practices of engineers beyond your immediate team or department. • Adaptable in a fast-paced startup environment where priorities may change quickly and frequently. Pluses • Bachelor’s or Master’s degree in Computer Science or a related field. • Familiarity with regulated software systems in any industry, such as HIPAA, ISO, or FDA. • Experience designing and architecting event-driven architectures. • Experience with AWS serverless infrastructure. • Experience in the life sciences, healthcare, or genomics domain. Expected Interview Process • Initial Screen 2) Technical Interviews 3) Leadership Interviews 4) Offer Expected Pay For This Role There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: • US: $173,000 - $234,500 USD • CA: $173,000 - $218,000 CAD • Expected Helix Discretionary Annual Bonus: 15% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your First 90 Days • First 5 days: You’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. • Day 5 - 30: You’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. • Day 30 - 90: You’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. Compensation The base pay range for this role is $173,000 – $234,500 per year.

Lead technical direction, design and implement software systems, mentor engineers, and drive engineering standards. | 10+ years software engineering experience, full-stack proficiency, cloud distributed systems knowledge, AI adoption experience, and leadership skills. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. What is special about this role? The Helix Experience Team builds the software platform and user experiences that guide patients and providers through their entire genetics journey, from enrollment through results delivery. As a Staff Software Engineer, you will set the technical direction for this platform and shape engineering standards across the organization. As a Staff Software Engineer - Experience, you will: • Guide and define the strategic technical direction for the Experience platform and wider Engineering organization. • Shape how Helix Engineering utilizes AI and advance our AI development best practices. • Direct AI agents to automate entire engineering workflows, including codifying our prompt libraries and context frameworks. • Design, architect, and implement software systems for our genomic applications and services, with a focus on the patient and provider experience. • Drive complex, ambiguous projects from scoping to production with autonomy, owning the design, architecture and implementation strategy. • Collaborate and lead cross-functional work with product managers, designers, user experience researchers, scientists, and our business leaders to drive meaningful outcomes to the business. • Shape the engineering standards, delivery practices, and quality bars within all of Engineering. • Serve as a dedicated technical mentor, helping grow our next generation of technical leaders. • Champion durable solutions that eliminate entire categories of technical debt and raise reliability. About you: • 10+ years of equivalent professional experience as a Software Engineer, with a track record of impact at scale. • A strong product engineering mindset, with technical decisions anchored in customer and business outcomes. • Operates with a high degree of autonomy, identifies problems before they're escalated and drives them to resolution proactively. • Experience implementing and a passion for driving AI adoption in engineering workflows, with a proven ability to build automated safeguards and evaluations that validate AI-generated code at scale. • Proficiency with distributed systems built on cloud infrastructure such as AWS, GCP, or Azure. • Deep full-stack expertise, proficient in a backend language such as Go, Java, Python, Scala, or Rust. • Familiarity and experience developing and maintaining SPA’s on frameworks such as React, Next.js, Vue.js or similar using TypeScript/JavaScript. • A track record of raising the technical standards and practices of engineers beyond your immediate team or department. • Adaptable in a fast-paced startup environment where priorities may change quickly and frequently. Pluses: • Bachelor’s or Master’s degree in Computer Science or a related field. • Familiarity with regulated software systems in any industry, such as HIPAA, ISO, or FDA. • Experience designing and architecting event-driven architectures. • Experience with AWS serverless infrastructure. • Experience in the life sciences, healthcare, or genomics domain. Expected Interview Process: 1) Initial Screen 2) Technical Interviews 3) Leadership Interviews 4) Offer Expected Pay For This Role: There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: • US: $173,000 - $234,500 USD • CA: $173,000 - $218,000 CAD • Expected Helix Discretionary Annual Bonus: 15% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your First 90 days: • First 5 days: You’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. • Day 5 - 30: You’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. Day 30 - 90: You’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. #LI-Remote Compensation The base pay range for this role is $173,000 – $234,500 per year.

Lead cloud infrastructure strategy, architecture, automation, and mentoring in a genomics healthcare company. | 5+ years cloud architecture and software development experience with AWS, Linux, scripting, and infrastructure automation. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. Your Career Path & Development We are committed to your long-term growth. We invest in you through: • Cutting-Edge AI Tooling: We equip our engineers to innovate at speed. You'll have full access to GitHub Copilot, frontier models (like Claude and OpenAI), Gemini, and other new tools as they emerge, all supported by our dedicated internal AI team. • Continuous Learning: Sharpen your skills with full access to the entire Udemy learning database. • Internal Mentorship: Learn from experts across our global team through tech demos, pair programming, and collaborative projects. • Clear Advancement: We provide a framework for you to grow from one role to the next, with clear expectations and support from your manager. • Travel: Opportunities to travel to the US for collaboration with our global teams. Your Impact In This Role As a Senior DevOps & Infrastructure Engineer – Cloud & Automation at Helix, you will play a pivotal role in architecting, and securing our critical cloud infrastructure that supports our platform. You collaborate closely with product managers, scientists, and other engineers to innovate and evolve our cloud infrastructure while ensuring reliability, scalability, and security. As a Senior Infrastructure Engineer – Cloud & Automation, you will: • Lead the strategic evolution of our cloud infrastructure, proactively identifying opportunities to enhance support for product teams. Drive innovation in cloud infrastructure strategy. • Collaborate with product management, scientists, and engineering teams to understand intricate requirements and develop comprehensive, forward-thinking engineering designs. • Architect and implement highly reliable and massively scalable cloud infrastructure solutions on AWS and potentially other platforms, anticipating future growth and evolving user and health system needs. Ensure alignment with the long-term architectural vision. • Champion and promote Cloud Engineering best practices across teams, influencing technical direction and standards. • Strategically lead initiatives to optimize cloud spending, demonstrating a strong understanding of budget ROI and resource utilization. • Spearhead the development and advancement of sophisticated CI/CD pipelines for highly automated, efficient, and resilient build, test, and deployment processes. • Define and implement comprehensive observability strategies, selecting and managing advanced tools to provide deep insights into system health and performance, and proactively predict and mitigate potential issues. • Mentor and guide Infrastructure Engineers by providing technical expertise, constructive feedback, coaching, and support to foster their professional development and drive excellence in cloud operations. About You • Experience integrating and utilizing AI-powered tools for proactive observability, cost optimization, and code analysis to improve cloud operations and development. • Ability to evaluate and recommend new AI tools to enhance cloud operations and development workflows. • A strong passion for improving people’s lives through access to better information about their DNA • Minimum of 5+ years of progressive hands-on experience in cloud architecture, deployment, and operations, demonstrating increasing technical leadership and strategic impact. • 5+ years of significant software development experience in one of the following: Go, Python, or a similar language, with a proven track record of designing and implementing complex cloud-native applications and infrastructure. • 5+ years of in-depth experience in cloud computing, with at least 5 years of demonstrable expert-level experience with a broad range of AWS services and a deep understanding of cloud architectural patterns. • Participate in a rotating on-call schedule, demonstrating ownership, providing leadership during incidents, and driving root cause analysis and preventative measures. • Expert-level sysadmin skills in a Linux environment, including mastery of Bash and other scripting languages for advanced automation, diagnostics, and performance tuning. • Extensive experience in designing and implementing infrastructure-as-code tooling/frameworks — e.g., Terraform and CDK — at scale, including defining best practices and standards. • A strong affinity for and proven ability to champion an engineering culture that emphasizes Agile methodologies, DevOps principles, and continuous delivery practices across teams. • Exceptional communication and interpersonal skills, with the proven ability to articulate complex technical concepts clearly and persuasively to diverse audiences, including executive stakeholders. Pluses • Direct experience with CircleCi, Rollbar and Pagerduty • Familiarity with full-stack development • Familiarity with regulated software systems and entities • AWS or other cloud certifications • Multi Cloud experience (AWS, GCP, Azure) • BS+ in Computer Science; coursework in genetics or bioinformatics Expected Interview Process • Initial Screen 2) Second Screen 3) Technical Screen 4) Final Loop Expected Pay For This Role There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: $148,000 - $190,000 • Expected Helix Discretionary Annual Bonus: 10% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your Onboarding Week We want to make sure your first week is spent learning the foundations. You will be invited to live orientation sessions and spend time with your hiring manager developing your individual roadmap to success. This experience will include sessions that cover your benefits, security & privacy training, an introduction to the OKR framework used at Helix and our communication tools and norms. What To Expect During Your First 90 Days First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. Remote

Lead cloud infrastructure architecture, automation, and mentoring to support scalable, secure genomic healthcare platform. | Requires 5+ years cloud architecture and software development experience with AWS, Linux, and infrastructure-as-code tools. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. Your Career Path & Development We are committed to your long-term growth. We invest in you through: • Cutting-Edge AI Tooling: We equip our engineers to innovate at speed. You'll have full access to GitHub Copilot, frontier models (like Claude and OpenAI), Gemini, and other new tools as they emerge, all supported by our dedicated internal AI team. • Continuous Learning: Sharpen your skills with full access to the entire Udemy learning database. • Internal Mentorship: Learn from experts across our global team through tech demos, pair programming, and collaborative projects. • Clear Advancement: We provide a framework for you to grow from one role to the next, with clear expectations and support from your manager. • Travel: Opportunities to travel to the US for collaboration with our global teams. Your Impact In This Role As a Senior DevOps & Infrastructure Engineer – Cloud & Automation at Helix, you will play a pivotal role in architecting, and securing our critical cloud infrastructure that supports our platform. You collaborate closely with product managers, scientists, and other engineers to innovate and evolve our cloud infrastructure while ensuring reliability, scalability, and security. As a Senior Infrastructure Engineer – Cloud & Automation, you will: • Lead the strategic evolution of our cloud infrastructure, proactively identifying opportunities to enhance support for product teams. Drive innovation in cloud infrastructure strategy. • Collaborate with product management, scientists, and engineering teams to understand intricate requirements and develop comprehensive, forward-thinking engineering designs. • Architect and implement highly reliable and massively scalable cloud infrastructure solutions on AWS and potentially other platforms, anticipating future growth and evolving user and health system needs. Ensure alignment with the long-term architectural vision. • Champion and promote Cloud Engineering best practices across teams, influencing technical direction and standards. • Strategically lead initiatives to optimize cloud spending, demonstrating a strong understanding of budget ROI and resource utilization. • Spearhead the development and advancement of sophisticated CI/CD pipelines for highly automated, efficient, and resilient build, test, and deployment processes. • Define and implement comprehensive observability strategies, selecting and managing advanced tools to provide deep insights into system health and performance, and proactively predict and mitigate potential issues. • Mentor and guide Infrastructure Engineers by providing technical expertise, constructive feedback, coaching, and support to foster their professional development and drive excellence in cloud operations. About You • Experience integrating and utilizing AI-powered tools for proactive observability, cost optimization, and code analysis to improve cloud operations and development. • Ability to evaluate and recommend new AI tools to enhance cloud operations and development workflows. • A strong passion for improving people’s lives through access to better information about their DNA • Minimum of 5+ years of progressive hands-on experience in cloud architecture, deployment, and operations, demonstrating increasing technical leadership and strategic impact. • 5+ years of significant software development experience in one of the following: Go, Python, or a similar language, with a proven track record of designing and implementing complex cloud-native applications and infrastructure. • 5+ years of in-depth experience in cloud computing, with at least 5 years of demonstrable expert-level experience with a broad range of AWS services and a deep understanding of cloud architectural patterns. • Participate in a rotating on-call schedule, demonstrating ownership, providing leadership during incidents, and driving root cause analysis and preventative measures. • Expert-level sysadmin skills in a Linux environment, including mastery of Bash and other scripting languages for advanced automation, diagnostics, and performance tuning. • Extensive experience in designing and implementing infrastructure-as-code tooling/frameworks — e.g., Terraform and CDK — at scale, including defining best practices and standards. • A strong affinity for and proven ability to champion an engineering culture that emphasizes Agile methodologies, DevOps principles, and continuous delivery practices across teams. • Exceptional communication and interpersonal skills, with the proven ability to articulate complex technical concepts clearly and persuasively to diverse audiences, including executive stakeholders. Pluses • Direct experience with CircleCi, Rollbar and Pagerduty • Familiarity with full-stack development • Familiarity with regulated software systems and entities • AWS or other cloud certifications • Multi Cloud experience (AWS, GCP, Azure) • BS+ in Computer Science; coursework in genetics or bioinformatics Expected Interview Process • Initial Screen 2) Second Screen 3) Technical Screen 4) Final Loop Expected Pay For This Role There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: $148,000 - $190,000 • Expected Helix Discretionary Annual Bonus: 10% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your Onboarding Week We want to make sure your first week is spent learning the foundations. You will be invited to live orientation sessions and spend time with your hiring manager developing your individual roadmap to success. This experience will include sessions that cover your benefits, security & privacy training, an introduction to the OKR framework used at Helix and our communication tools and norms. What To Expect During Your First 90 Days First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. Remote

Lead cloud infrastructure architecture, automation, and security to support scalable genomic platform. | Requires 5+ years cloud architecture and software development experience with AWS, Linux, and infrastructure-as-code tools. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. Your Career Path & Development We are committed to your long-term growth. We invest in you through: • Cutting-Edge AI Tooling: We equip our engineers to innovate at speed. You'll have full access to GitHub Copilot, frontier models (like Claude and OpenAI), Gemini, and other new tools as they emerge, all supported by our dedicated internal AI team. • Continuous Learning: Sharpen your skills with full access to the entire Udemy learning database. • Internal Mentorship: Learn from experts across our global team through tech demos, pair programming, and collaborative projects. • Clear Advancement: We provide a framework for you to grow from one role to the next, with clear expectations and support from your manager. • Travel: Opportunities to travel to the US for collaboration with our global teams. Your Impact In This Role As a Senior DevOps & Infrastructure Engineer – Cloud & Automation at Helix, you will play a pivotal role in architecting, and securing our critical cloud infrastructure that supports our platform. You collaborate closely with product managers, scientists, and other engineers to innovate and evolve our cloud infrastructure while ensuring reliability, scalability, and security. As a Senior Infrastructure Engineer – Cloud & Automation, you will: • Lead the strategic evolution of our cloud infrastructure, proactively identifying opportunities to enhance support for product teams. Drive innovation in cloud infrastructure strategy. • Collaborate with product management, scientists, and engineering teams to understand intricate requirements and develop comprehensive, forward-thinking engineering designs. • Architect and implement highly reliable and massively scalable cloud infrastructure solutions on AWS and potentially other platforms, anticipating future growth and evolving user and health system needs. Ensure alignment with the long-term architectural vision. • Champion and promote Cloud Engineering best practices across teams, influencing technical direction and standards. • Strategically lead initiatives to optimize cloud spending, demonstrating a strong understanding of budget ROI and resource utilization. • Spearhead the development and advancement of sophisticated CI/CD pipelines for highly automated, efficient, and resilient build, test, and deployment processes. • Define and implement comprehensive observability strategies, selecting and managing advanced tools to provide deep insights into system health and performance, and proactively predict and mitigate potential issues. • Mentor and guide Infrastructure Engineers by providing technical expertise, constructive feedback, coaching, and support to foster their professional development and drive excellence in cloud operations. About You • Experience integrating and utilizing AI-powered tools for proactive observability, cost optimization, and code analysis to improve cloud operations and development. • Ability to evaluate and recommend new AI tools to enhance cloud operations and development workflows. • A strong passion for improving people’s lives through access to better information about their DNA • Minimum of 5+ years of progressive hands-on experience in cloud architecture, deployment, and operations, demonstrating increasing technical leadership and strategic impact. • 5+ years of significant software development experience in one of the following: Go, Python, or a similar language, with a proven track record of designing and implementing complex cloud-native applications and infrastructure. • 5+ years of in-depth experience in cloud computing, with at least 5 years of demonstrable expert-level experience with a broad range of AWS services and a deep understanding of cloud architectural patterns. • Participate in a rotating on-call schedule, demonstrating ownership, providing leadership during incidents, and driving root cause analysis and preventative measures. • Expert-level sysadmin skills in a Linux environment, including mastery of Bash and other scripting languages for advanced automation, diagnostics, and performance tuning. • Extensive experience in designing and implementing infrastructure-as-code tooling/frameworks — e.g., Terraform and CDK — at scale, including defining best practices and standards. • A strong affinity for and proven ability to champion an engineering culture that emphasizes Agile methodologies, DevOps principles, and continuous delivery practices across teams. • Exceptional communication and interpersonal skills, with the proven ability to articulate complex technical concepts clearly and persuasively to diverse audiences, including executive stakeholders. Pluses • Direct experience with CircleCi, Rollbar and Pagerduty • Familiarity with full-stack development • Familiarity with regulated software systems and entities • AWS or other cloud certifications • Multi Cloud experience (AWS, GCP, Azure) • BS+ in Computer Science; coursework in genetics or bioinformatics Expected Interview Process • Initial Screen 2) Second Screen 3) Technical Screen 4) Final Loop Expected Pay For This Role There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: $148,000 - $190,000 • Expected Helix Discretionary Annual Bonus: 10% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your Onboarding Week We want to make sure your first week is spent learning the foundations. You will be invited to live orientation sessions and spend time with your hiring manager developing your individual roadmap to success. This experience will include sessions that cover your benefits, security & privacy training, an introduction to the OKR framework used at Helix and our communication tools and norms. What To Expect During Your First 90 Days First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. Remote

Lead and architect scalable, reliable, and secure cloud infrastructure on AWS, drive innovation and best practices, mentor engineers, and optimize cloud operations. | 5+ years of cloud architecture and software development experience with AWS, Go/Python, infrastructure-as-code, CI/CD, Linux sysadmin skills, and leadership in cloud engineering. | Who We Are & What We Do At Helix, our mission is simple: to help everyone improve their lives through their DNA. Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics. Your Career Path & Development We are committed to your long-term growth. We invest in you through: • Cutting-Edge AI Tooling: We equip our engineers to innovate at speed. You'll have full access to GitHub Copilot, frontier models (like Claude and OpenAI), Gemini, and other new tools as they emerge, all supported by our dedicated internal AI team. • Continuous Learning: Sharpen your skills with full access to the entire Udemy learning database. • Internal Mentorship: Learn from experts across our global team through tech demos, pair programming, and collaborative projects. • Clear Advancement: We provide a framework for you to grow from one role to the next, with clear expectations and support from your manager. • Travel: Opportunities to travel to the US for collaboration with our global teams. Your Impact In This Role As a Senior DevOps & Infrastructure Engineer – Cloud & Automation at Helix, you will play a pivotal role in architecting, and securing our critical cloud infrastructure that supports our platform. You collaborate closely with product managers, scientists, and other engineers to innovate and evolve our cloud infrastructure while ensuring reliability, scalability, and security. As a Senior Infrastructure Engineer – Cloud & Automation, you will: • Lead the strategic evolution of our cloud infrastructure, proactively identifying opportunities to enhance support for product teams. Drive innovation in cloud infrastructure strategy. • Collaborate with product management, scientists, and engineering teams to understand intricate requirements and develop comprehensive, forward-thinking engineering designs. • Architect and implement highly reliable and massively scalable cloud infrastructure solutions on AWS and potentially other platforms, anticipating future growth and evolving user and health system needs. Ensure alignment with the long-term architectural vision. • Champion and promote Cloud Engineering best practices across teams, influencing technical direction and standards. • Strategically lead initiatives to optimize cloud spending, demonstrating a strong understanding of budget ROI and resource utilization. • Spearhead the development and advancement of sophisticated CI/CD pipelines for highly automated, efficient, and resilient build, test, and deployment processes. • Define and implement comprehensive observability strategies, selecting and managing advanced tools to provide deep insights into system health and performance, and proactively predict and mitigate potential issues. • Mentor and guide Infrastructure Engineers by providing technical expertise, constructive feedback, coaching, and support to foster their professional development and drive excellence in cloud operations. About You • Experience integrating and utilizing AI-powered tools for proactive observability, cost optimization, and code analysis to improve cloud operations and development. • Ability to evaluate and recommend new AI tools to enhance cloud operations and development workflows. • A strong passion for improving people’s lives through access to better information about their DNA • Minimum of 5+ years of progressive hands-on experience in cloud architecture, deployment, and operations, demonstrating increasing technical leadership and strategic impact. • 5+ years of significant software development experience in one of the following: Go, Python, or a similar language, with a proven track record of designing and implementing complex cloud-native applications and infrastructure. • 5+ years of in-depth experience in cloud computing, with at least 5 years of demonstrable expert-level experience with a broad range of AWS services and a deep understanding of cloud architectural patterns. • Participate in a rotating on-call schedule, demonstrating ownership, providing leadership during incidents, and driving root cause analysis and preventative measures. • Expert-level sysadmin skills in a Linux environment, including mastery of Bash and other scripting languages for advanced automation, diagnostics, and performance tuning. • Extensive experience in designing and implementing infrastructure-as-code tooling/frameworks — e.g., Terraform and CDK — at scale, including defining best practices and standards. • A strong affinity for and proven ability to champion an engineering culture that emphasizes Agile methodologies, DevOps principles, and continuous delivery practices across teams. • Exceptional communication and interpersonal skills, with the proven ability to articulate complex technical concepts clearly and persuasively to diverse audiences, including executive stakeholders. Pluses • Direct experience with CircleCi, Rollbar and Pagerduty • Familiarity with full-stack development • Familiarity with regulated software systems and entities • AWS or other cloud certifications • Multi Cloud experience (AWS, GCP, Azure) • BS+ in Computer Science; coursework in genetics or bioinformatics Expected Interview Process • Initial Screen 2) Second Screen 3) Technical Screen 4) Final Loop Expected Pay For This Role There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity • Expected Helix Base: $148,000 - $190,000 • Expected Helix Discretionary Annual Bonus: 10% of your annual salary • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model. Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits: • Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend What To Expect During Your Onboarding Week We want to make sure your first week is spent learning the foundations. You will be invited to live orientation sessions and spend time with your hiring manager developing your individual roadmap to success. This experience will include sessions that cover your benefits, security & privacy training, an introduction to the OKR framework used at Helix and our communication tools and norms. What To Expect During Your First 90 Days First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U. Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice. Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. Remote