GondolaBio

Leading guest experience strategies, managing large teams, and operational excellence in cultural and entertainment venues. | Extensive experience in guest experience, operations, and leadership, but lacking in clinical pharmacology, drug development, and scientific research skills. | About GondolaBio GondolaBio is a clinical-stage biopharmaceutical company focused on developing breakthrough therapeutics for genetic diseases. GondolaBio is an independent sister company to BridgeBio, originally carved out in 2024 after securing $300M in private financing from external investors. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases. Who You Are You are an experienced clinical pharmacology leader with deep expertise in early clinical development and a strong track record of informing dose selection and development decisions for innovative therapies. You are comfortable setting strategy at the portfolio and program level while also rolling up your sleeves to execute in a small, fast-moving biotech environment, and you are energized by the opportunity to help build and shape clinical pharmacology approaches as the company and pipeline grow. You thrive at the intersection of pharmacology, translational science, and clinical development, and you bring a pragmatic, data-driven mindset to decision-making, particularly in rare and genetically defined diseases. Key Responsibilities • Clinical pharmacology leadership & program ownership (preclinical, FIH, early PoC): Serve as the clinical pharmacology leader for multiple programs in GondolaBio’s pipeline, defining stage-appropriate PK/PD, exposure–response, and dose-selection strategies to support rapid, high-quality decisions through early proof of concept. • FIH and early development strategy: Lead clinical pharmacology strategy for first-in-human and early Phase 1/2 studies, including starting dose rationale, dose escalation design, SAD/MAD strategy, and integration of nonclinical and translational data. • PK/PD and translational integration: Design, interpret, and communicate PK/PD, biomarker, and exposure–response analyses to inform dose optimization and go/no-go decisions, in close partnership with Translational and Clinical Development teams. • Model-informed drug development: Apply fit-for-purpose pharmacometric and modeling approaches to support early development decisions and regulatory interactions. • Regulatory and cross-functional partnership: Partner across functions to support INDs, regulatory interactions, and integrated development plans; clearly communicate clinical pharmacology insights to senior leadership. • External partner management: Oversee external pharmacometrics vendors, CROs, and consultants as needed to ensure timely, high-quality execution. Preferred Education & Experience • Ph.D., Pharm.D., M.D., or equivalent advanced degree in pharmacology, pharmaceutical sciences, or a related discipline. • 15+ years of experience in clinical pharmacology and/or pharmacometrics, including leadership at the program or portfolio level. • Demonstrated record of supporting IND-stage programs through first-in-human and early clinical proof of concept. • Strong expertise in dose selection, PK/PD integration, exposure–response, and early safety margin assessment. • Experience working across multiple modalities (experience with oligonucleotides and small molecules is a plus). • Experience operating in small or mid-sized biotech environments where leaders are both strategic and hands-on Nice-to-Haves • Experience applying model-informed drug development in regulatory interactions. • Familiarity with rare diseases or development programs with slow or indirect clinical endpoints. • Prior experience serving as a senior clinical pharmacology voice with executive leadership or boards. • Comfort making decisions with limited data while maintaining scientific rigor No matter your role at GondolaBio, successful team members are • Patient Champions, who put patients first and uphold strict ethical standards. • Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset. • Truth Seekers, who are detailed, rational, and humble problem solvers. • Individuals Who Inspire Excellence in themselves and those around them. • High-quality executors, who execute against goals and milestones with quality, precision, and speed. What We Offer • Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts. • A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak. • An unyielding commitment to always putting patients first. • A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science. • A place where you own the vision – both for your program and your own career path. • A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game. • Access to learning and development resources to help you get in the best professional shape of your life. • Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs). • Flexible PTO. • Rapid career advancement for strong performers. • Potential ability to work on multiple GondolaBio Pharma programs across multiple therapeutic areas over time · Partnerships with leading institutions. • Commitment to Diversity, Equity & Inclusion. The base pay range for this position is $302,000 to $360,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.

Build and maintain relationships with patient advocacy groups, coordinate patient advocacy operations and communications, support educational programming, and manage logistics and financial processes for stakeholder engagements. | Bachelor’s degree in life sciences or related field, 2+ years in patient advocacy or similar, strong communication skills, ability to build relationships with patient communities, and willingness to travel up to 15%. | Company Background: GondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting-edge biological research to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation. To learn more, visit us at gondolabio.com Who You Are: Putting patients first is a core value of GondolaBio, Inc. We are committed to engaging patients, families, caregivers, and community advocates throughout the drug development process to understand their challenges and priorities, adapting our efforts to meet their needs. Reporting to the Director of Patient Advocacy, the Patient Advocacy Manager/Senior Manager will build and maintain productive, enduring relationships with patient advocacy organizations and community leaders while providing operational and project coordination support for GondolaBio's patient advocacy function. This role will collaborate with internal and external stakeholders to develop and support educational programming that addresses patient, caregiver, and community needs while promoting innovation and access. The position involves implementing communication strategies to share GondolaBio-developed resources, program updates, and other relevant information with the patient community. The successful candidate will work closely with the Director of Patient Advocacy across multiple GondolaBio development programs at various stages, ensuring patient voices remain central to our mission. Responsibilities: • Champion a people-first mentality by amplifying the patient and caregiver voice across internal teams • Integrate patient stories, experiences, and unmet needs into company communications, activities, and materials • Build and nurture relationships with patient communities through activities of mutual interest • Develop and implement patient advocacy operations, communication platforms, and strategic activities in collaboration with development, operations, medical, legal, compliance, communications, and commercial teams • Partner with Patient Advocacy, Medical Affairs, Business Development, and Communications teams to streamline external messaging and coordinate communication plans • Plan and organize external meetings and events tailored to specific requirements, target audiences, and strategic objectives • Provide comprehensive meeting and logistics preparation, including agenda development and material coordination • Manage financial processes and reimbursement activities for external stakeholder engagements, including Advisory Board and Task Force meetings • Provide logistical and operational support for grant and sponsorship processes • Collaborate with internal departments and third parties to create, manage, and process statements of work, purchase orders, master service agreements, and other confidential departmental records • Handle highly confidential and sensitive business matters with discretion • Complete project administration responsibilities and additional assignments as directed Education, Experience & Skills Requirements: • Bachelor’s degree (or higher) in a relevant field is required (e.g., life sciences); a post-graduate degree in counseling, social work, genetic counseling, public health, nursing, pharmacy, or life sciences strongly valued • A minimum of 2-years in patient advocacy/advocacy relations, non-profit experience or a similar function is preferred • Demonstrated ability to build relationships with patient advocacy organizations, professional associations, individuals living with conditions and their families, and other stakeholders are required • Strong written, verbal, and presentation communication skills are required; the candidate should be flexible, personable, and easily collaborate with colleagues and advocates • A passion for helping the patient community • The ability to travel up to 10-15% is required