Day One Biopharmaceuticals

Leading strategic HR partnership, internal communications, and culture development for a biotech organization. | 15+ years of senior HR leadership experience, deep expertise in total rewards, and experience with scientific organizations. | SENIOR DIRECTOR, STRATEGIC PEOPLE BUSINESS PARTNER At Day One, we are focused on advancing first- or best-in-class medicines for childhood and adult diseases with equal intensity. We were founded to address the lack of new therapies resulting from the traditional drug development model, that has left children with cancer and their families waiting too long for new, life-changing treatments. Our aim is to accelerate better, targeted treatments so patients of any age can look forward from ‘day one’ to the future they’ve envisioned. POSITION SUMMARY: This is a strategic, enterprise-level HR leadership role for an experienced executive who wants to be deeply embedded in the business, influencing decisions, shaping leaders, and building durable people systems, without the administrative drag or title inflation that often comes with senior HR roles. As the primary HR Business Partner to Research & Development, you will work directly with the Head of R&D and their leadership team, serving as a trusted advisor on organizational strategy, leadership effectiveness, talent, and culture. You will also play a critical enterprise role in shaping internal communications and total compensation strategy, two capabilities essential to Day One’s next phase of growth. This role reports to the VP, People Business Partners. This role is intentionally scoped for impact, influence, and trust, not empire-building. Strong preference for candidates in the Greater Boston area who can work a hybrid schedule with regular in-office days. ESSENTIAL DUTIES AND RESPONSIBILITIES: Strategic HR Partnership – R&D Serve as the senior HR advisor to the Head of R&D and his leadership team, partnering on strategy, org design, workforce planning, leadership development, and succession. Translate scientific and portfolio strategy into people and organizational plans that scale with rigor and flexibility. Coach senior leaders through complex decisions of growth, change, performance, and culture, grounded in sound judgment and business context. Act as a connective tissue between R&D and the broader enterprise, ensuring alignment without slowing momentum. Enterprise Internal Communications Partner closely with the Chief People Officer to design and mature a robust internal communications capability appropriate for a growing public biotech. Advise executives on clear, authentic communication during moments of change, growth, and ambiguity. Help leaders in crafting a clear story about the direction of Day One and how each employee plays a role in the mission. Culture, Values & Inclusion Serve as a visible steward of Day One’s culture and leadership expectations. Embed inclusion and belonging into talent, rewards, leadership behaviors, and decision-making—not as a program, but as a way of working. Model executive-level partnership grounded in trust, discretion, and accountability. QUALIFICATIONS 15+ years of senior HR leadership experience, ideally within Biotech, TechBio, or Healthcare. Sound judgment, emotional intelligence, and comfort navigating ambiguity. Demonstrated success partnering with R&D or scientific organizations at the executive level. Deep expertise in total rewards and compensation strategy, especially pay for performance, goal setting, and team performance. Strong business and financial acumen: you understand how people strategy enables pipeline execution and enterprise value. Executive presence paired with humility: you influence through credibility, not volume. A builder’s mindset: you enjoy creating structure, clarity, and trust where they matter most. How We Work at Day One At Day One, how we show up matters. Audacious Outcomes: We do what we say we will do. Urgency with Purpose: Decisions grounded in purpose and impact. Building Bridges, Not Silos: Progress through partnership. Inclusion and belonging: Where diverse perspectives strengthen outcomes and honest conversations are delivered with respect. You don’t need to be perfect. You do need to be thoughtful, accountable, and human. We take the mission seriously and ourselves lightly. A well-placed metaphor is welcome if it helps people see more clearly. Why This Role Is Different Direct partnership with R&D leadership at a critical inflection point Broad enterprise scope with real ownership (not advisory-only) Opportunity to shape culture, rewards, and leadership in a growing public biotech A chance to apply deep expertise where it truly matters—without unnecessary layers The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. INTERVIEW INTEGRITY At Day One, we expect each candidate to engage authentically, representing their true qualifications and experiences. As part of our screening process, we will conduct several interviews and background verification. This ensures candidates have the skills they claim and align with our values. We are excited to learn more about you and to create a genuine experience for everyone. COMPENSATION AND BENEFITS The salary range for this position is $260,000 - $280,000. Day One considers a range of factors when determining base compensation. These considerations mean actual compensation will vary. Please visit https://www.dayonebio.com/benefits to see our competitive benefits. DISCLAIMER Day One Biopharmaceuticals is committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. We are unable to sponsor or take over sponsorship of any applicant work visas at this time. Recruitment & Staffing Agencies: Day One Biopharmaceuticals does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Day One Biopharmaceuticals or its employees is strictly prohibited unless contacted directly by Day One Biopharmaceutical’s internal HR team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Day One Biopharmaceuticals, and Day One Biopharmaceuticals will not owe any referral or other fees with respect thereto.

Lead and align cross-functional teams to execute clinical-stage drug development programs from Phase 1 through commercialization, ensuring strategic and operational success. | Extensive industry experience in drug development, with leadership in oncology or rare disease, and strong cross-functional collaboration skills. | VICE PRESIDENT, PRODUCT TEAM LEADER At Day One, we are focused on advancing first- or best-in-class medicines for childhood and adult diseases with equal intensity. We were founded to address the lack of new therapies resulting from the traditional drug development model, that has left children with cancer and their families waiting too long for new, life-changing treatments. Our aim is to accelerate better, targeted treatments so patients of any age can look forward from ‘day one’ to the future they’ve envisioned. POSITION SUMMARY: We are seeking a strategic VP, Product Team Leader (PTL) to lead one or more cross-functional clinical-stage development program from Phase 1 through commercialization. The PTL will be responsible for establishing the long-term vision and strategy while enabling teams to achieve strong execution of the program plan through a close-collaboration with a cross-functional core team of Program Management, R&D, CMC and commercial leaders ensuring achievement of the program goals. The ideal candidate will be a strategic and flexible leader well-versed in drug development, with established pharmaceutical industry executive experience, innate cross-functional collaboration skills, and a commitment to scientific excellence, The candidate must be a strong influencer who can integrate effectively and align stakeholders across different functions and the Executive and Operating Committees. Reporting to the Head of R&D, as a member of the Research and Development Leadership Team you will champion the program with significant executive visibility and potential for patient impact globally This position should be based in either the San Francisco Bay Area, or the greater Boston area, with the expectation of at least two days/week in the office. Occasional travel will also be expected for in-person meetings. For the ideal candidate, a remote location to either San Francisco or Boston may be considered, however increased travel may be required in this instance. ESSENTIAL DUTIES AND RESPONSIBILITIES: Lead strategy creation and alignment of internal and external experts with overall product vision for one or more Day One product teams, resulting in a comprehensive Integrated Development Plan, ensuring all program initiatives are in pursuit of a coherent product vision. Hold primary accountability for the forward progress of Day One’s development programs, as measured by the achievement of milestones and other key performance indicators defined by the Product Team (PT) and endorsed by senior leadership, effectively balancing scientific, regulatory and commercial objectives Work closely with functional leaders and relevant sub-teams, leading the PT in development, evolution, and execution of an integrated global strategic project plan, including scientific, clinical, regulatory, CMC, commercial, and corporate/business considerations, doing so through building trusted relationships and ensuring alignment in pursuit of program and corporate goals Communicate program strategy, progress, milestones, timelines, budget and drive decisions in senior leadership forums such as the Operating Committee. Distill program strategy and progress for presentation to key stakeholders such as the Board of Directors In partnership with Clinical Research, Medical Affairs, Commercial leadership and other relevant stakeholders, establish and maintain key external stakeholder relationships relevant to the programs and products success In partnership with Program Management, set direction, milestones and goals for the team, ensuring program strategy is aligned with corporate objectives and functional strategies Lead the PT in developing and meeting the requirements of the relevant target product profiles Work with Program Management to create and maintain an integrated program timeline detailing the development paths to registration across treatment settings and geographies Work with Program Management to monitor team goals and team effectiveness Work with the PT and Program Management to ensure timely execution of the project plan within allocated Anticipate major risks to achievement of key deliverables and put appropriate mitigation plans in place Perform integrated scenario planning/assessment for the development plan Work with medical affairs and the commercial organization on scientific messaging and competitive positioning Support the commercial organization in forecasting, launch, and portfolio planning efforts Lead the PT in development of cross-functional program budget and resource drivers and Long-Range Plan (LRP) assumptions and work with functional heads to ensure appropriate program resources are in place Partner with the Head of R&D, other Product Team Leads, the R&D Leadership Team and other key stakeholders such as Finance, Commercial, and Technical Operations and People to iteratively optimize the Product Team-centered model across the Day One portfolio Partner with the Head of R&D, Finance, the Head of the Program Management Organization, and other key stakeholders in support of portfolio prioritization tools and processes as needed to support Day One’s portfolio growth. QUALIFICATIONS Advanced degree (e.g. MS, MD, PhD, PharmD, MBA or equivalent) in life sciences or commensurate experience strongly preferred: Bachelor’s degree is required 15+ years of industry experience in drug development, including a comprehensive understanding of early- and late-stage clinical drug development, precision medicine and global regulatory requirements; the preferred candidate will have had direct functional or project-oriented experience across the spectrum of development, from late preclinical through marketing authorization, inclusive of life cycle management. 5+ years of cross-functional project leadership in oncology drug development or rare disease Understanding of the manufacturing considerations of small molecules, biologics and ADC therapeutics Demonstrated ability to integrate and synthesize data, assess strategic alternatives, and forge alignment of functions and executive management across business objectives, development strategy, and operational plans Experienced partnering across the spectrum of functional areas to advance program objectives and a demonstrated understanding of and appreciation for commercial requirements Track record in leading teams to strong results in a matrix environment and demonstrated skills in motivation of teams Ability to cultivate excellent cross-functional collaborations Strategic thinker with strong decision-making and analytical skills Excellent communication and influencing skills with a proven ability to work with executive management to obtain endorsement of development plans and budget/personnel support; the ideal candidate will translate a multidimensional asset strategy across all stakeholders, including the Board of Directors, incorporating both the competitive landscape and corporate objectives Ability to perform in a fast-paced, dynamic, cross-functional, and mission-driven environment; prior work experience in small biotech highly Mission-driven leadership that fosters inspiring, high-performing teams acting with accountability and empowerment to achieve clear program goals is essential Willingness to assume full product accountability for both the strategic and operational plan, including program budget management in pursuit of clear program objectives, is critical. Foster and facilitate a culture where diverse perspectives are heard in pursuit of optimal decision making, with skills to negotiate through challenging conversations to achieve positive outcomes; Humility and high self-awareness carry a high premium in Day One’s culture The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. INTERVIEW INTEGRITY At Day One, we expect each candidate to engage authentically, representing their true qualifications and experiences. As part of our screening process, we will conduct several interviews and background verification. This ensures candidates have the skills they claim and align with our values. We are excited to learn more about you and to create a genuine experience for everyone. COMPENSATION AND BENEFITS The salary range for this position is $300,000 - $330,000. Day One considers a range of factors when determining base compensation. These considerations mean actual compensation will vary. Please visit https://www.dayonebio.com/benefits to see our competitive benefits. DISCLAIMER Day One Biopharmaceuticals is committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. We are unable to sponsor or take over sponsorship of any applicant work visas at this time. Recruitment & Staffing Agencies: Day One Biopharmaceuticals does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Day One Biopharmaceuticals or its employees is strictly prohibited unless contacted directly by Day One Biopharmaceutical’s internal HR team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Day One Biopharmaceuticals, and Day One Biopharmaceuticals will not owe any referral or other fees with respect thereto.

Provide strategic and operational QA leadership for biologics and ADC programs, ensuring compliance, quality, and risk management throughout development phases. | Requires 8+ years in QA, with at least 5 years in biologics or ADC development, and expertise in regulatory standards and manufacturing processes. | ASSOCIATE DIRECTOR, QUALITY ASSURANCE – BIOLOGICS & ADC At Day One, we are focused on advancing first- or best-in-class medicines for childhood and adult diseases with equal intensity. We were founded to address the lack of new therapies resulting from the traditional drug development model, that has left children with cancer and their families waiting too long for new, life-changing treatments. Our aim is to accelerate better, targeted treatments so patients of any age can look forward from ‘day one’ to the future they’ve envisioned. POSITION SUMMARY: The Associate Director, Quality Assurance, serves as the primary QA lead for Antibody-Drug Conjugate (ADC) and biologics programs in early and mid-stage development (Phases 1–3). This role provides strategic and operational QA leadership across specifications setting, analytical method validation, batch disposition, change control, and deviation/CAPA management. The incumbent ensures phase-appropriate GxP compliance, aligns development activities with ICH Q5/Q6/Q7/Q8/Q9/Q10 expectations, and drives risk-based decision-making that supports both development agility and regulatory readiness. This role partners cross-functionally with CMC, Research, Tech Ops, Regulatory, and external CDMOs to ensure quality by design, data integrity (ALCOA+), and end-to-end traceability throughout the ADC development lifecycle.This position will report to the Senior Director, Quality Assurance. This position has the potential to be fully remote. Travel up to 20% will be required for in person meetings. ESSENTIAL DUTIES AND RESPONSIBILITIES: Strategic QA Leadership Functions as program QA owner for ADC and biologics assets, establishing the QA strategy and quality plan across Phases 1–3. Provides interpretation of FDA/EMA/ICH biologics and ATMP guidance, ensuring development activities are compliant, risk-based, and phase-appropriate. Anticipates regulatory expectations and drives inspection readiness across internal teams and CDMOs. Guides teams on phase-specific requirements (e.g., specification tightening, method validation depth, stability expectations, comparability strategies). Specifications, Analytical Methods, & Control Strategy Provides strategic QA oversight for method qualification, validation, transfer, and ongoing performance assessment for biologics and ADC-specific assays (e.g., DAR, conjugation profile, potency). Ensures analytical control strategies are aligned with QbD principles and development phase expectations. Batch Disposition & GMP Oversight Owns end-to-end QA oversight of drug substance, intermediates, payloads, linkers, conjugation steps, and drug product batches. Ensures batch record packages from CDMOs are complete, compliant, and meet internal quality standards before disposition. Provides high-level guidance on complex deviations and investigations, evaluating scientific adequacy, true root cause, and effectiveness of CAPAs. Assesses and approves change controls involving process changes, analytical methods, raw materials, and manufacturing sites. Phase-Appropriate Development Governance Advises teams on what is required vs. optional at each phase: Phase 1: Foundational specifications, qualified methods, essential stability, fit-for-purpose characterization; rapid but controlled changes. Phase 2: Method validation, increasing specification tightness, comparability expectations, enhanced process understanding. Phase 3: Validation readiness, process performance qualification strategy, commercial-level control strategy convergence. Ensures risks, data gaps, and regulatory impacts are identified and communicated early. Cross-Functional & External Leadership Serves as senior QA representative on CMC and Development Teams, driving quality risk assessments and program decision-making. Leads QA governance of CDMO relationships, oversees audit planning, evaluates vendor responses, and escalates systemic issues. QUALIFICATIONS BS/MS/PhD in life sciences or related discipline. 8+ years of QA experience, with at least 5 years in biologics or ADC development. Demonstrated expertise with ICH, 21 CFR Parts 210/211, 600–680, EMA biologics guidelines, and global clinical development expectations. Proven ability to set quality strategy, influence cross-functional teams, and make phase-appropriate compliance decisions. Deep understanding of biologics/ADC manufacturing, conjugation, analytics, and CMC development. Experience regulatory interactions, and inspection readiness. Excellent communication, negotiation, and leadership skills required for matrix collaboration. The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. INTERVIEW INTEGRITY At Day One, we expect each candidate to engage authentically, representing their true qualifications and experiences. As part of our screening process, we will conduct several interviews and background verification. This ensures candidates have the skills they claim and align with our values. We are excited to learn more about you and to create a genuine experience for everyone. COMPENSATION AND BENEFITS The salary range for this position is $180,000 - $190,000. Day One considers a range of factors when determining base compensation. These considerations mean actual compensation will vary. Please visit https://www.dayonebio.com/benefits to see our competitive benefits. DISCLAIMER Day One Biopharmaceuticals is committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. We are unable to sponsor or take over sponsorship of any applicant work visas at this time. Recruitment & Staffing Agencies: Day One Biopharmaceuticals does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Day One Biopharmaceuticals or its employees is strictly prohibited unless contacted directly by Day One Biopharmaceutical’s internal HR team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Day One Biopharmaceuticals, and Day One Biopharmaceuticals will not owe any referral or other fees with respect thereto.