Cogent Biosciences

Manage territory accounts by building relationships with healthcare professionals and stakeholders, developing account plans, and achieving sales targets. | Minimum 5+ years of pharmaceutical, biotech, or medical sales experience, with knowledge of industry trends, strong communication skills, and ability to manage complex accounts. | Who We Are: Cogent Biosciences is a publicly traded biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent’s lead program, bezuclastinib, is designed to selectively and potently inhibit exon 17 mutations found within the KIT receptor tyrosine kinase, including KIT D816V. KIT D816V is responsible for driving a rare and serious condition called Systemic Mastocytosis, and exon 17 mutations are also found in patients with gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Bezuclastinib has exhibited promising initial data across all three trials: APEX in AdvSM, SUMMIT in NonAdvSM and PEAK in GIST, including an encouraging safety profile across 600+ patients in single agent and combination dosing. The Role: The Clinical Account Manager (CAM) will serve as a critical member of the Customer Engagement Team and will have an exciting opportunity within Cogent to potentially launch Bezuclastinib in multiple indications across three disease states. The Clinical Account Manager will be responsible for meeting sales targets and utilizing all available resources while tailoring them to meet the customer's needs through a deep understanding of their requirements. Behaviors that are critical for success in this role are collaboration, communication, planning, relationship building, and the ability to execute tactical initiatives and provide timely feedback. CAMs will report directly to the Regional Business Director. Responsibilities: Holistically support and manage territory accounts by creating relationships with physicians, allied healthcare professionals (Advanced Practitioners, Nurses, Pharmacists), and business stakeholders (Office Practice Managers, Billers, etc.) Maintain a uniquely deep and nuanced understanding of territory, including Opinion Leaders (OL) and other influencers, treatment and utilization trends, payer and reimbursement dynamics, and competitive opportunities and challenges. Analyze business performance: Create and execute a comprehensive territory plan. This includes developing unique account plans, delivering branded sales messages, executing planned programs, scheduling and following up with medical education programs, and achieving or exceeding sales targets. Demonstrate clinical/disease/product expertise and deliver strategic customer education. Work closely with multiple Cogent internal stakeholders inside and outside the commercial organization to ensure strategic alignment and execution of key strategies/tactics to advance overall business objectives. Implement processes for appropriate patient identification and treatment management. Utilize internal relationships and develop external relationships with account stakeholders, including, but not limited to, HCPs and advanced practice providers, to service and manage accounts. Have a passion for our products through the entire sales cycle while always building our brand and never losing sight of how we serve patients. Leverage your passion for Oncology/Rare disease state awareness, industry, regulatory, and competitive changes to deliver agreed results. Desired Experience/Education and Personal Attributes: Ideal candidates have strong clinical selling skills, excellent communication/presentation skills, are effective working in teams and self-starters, as well as strategic and forward thinking. BA/BS or healthcare equivalent degree required. Minimum 5+ years of previous pharmaceutical, biotech, and/or medical sales experience with a strong preference for Rare Disease/Oncology/Hematology. Knowledge of the pharmaceutical marketplace and deep understanding of industry and broader trends in the healthcare landscape. Collaborative and organizationally savvy team player with a history of success in a matrixed setting. Strong negotiation, partnering, and influencing skills. Demonstrated ability to effectively manage business relationships with external strategic partners. Prior experience working in large accounts and/or hospitals required. Expert at navigating complexities and removing barriers to advance corporate objectives in service of patients, caregivers, and HCPs. Successful product launch experience preferred. Prior pharma/biotech start-up experience preferred. Technologically savvy and committed to leveraging data and advanced analytics daily to drive business results. Ability to travel on a frequent overnight basis, with occasional weekend travel, depending on business needs. Must possess a valid driver's license and have reliable access to a personal vehicle Salary Range: 0-100$USD Target Bonus: 15% Exact compensation will vary based on skills, experience, and location. Our Locations Waltham, MA: Our headquarters is located in the Greater Boston life sciences community, with an open, collaborative office environment designed to support teamwork and connection. Employees benefit from convenient on-site amenities, including free on-site parking and gym facilities in the building. Boulder, CO: Our Boulder location is home to Cogent’s discovery research organization and a key scientific hub with strong leadership based on site. Situated in the greater Denver-Boulder biopharmaceutical corridor, this office plays a central role in advancing our discovery efforts and pipeline. Our Offer To You At Cogent Biosciences, we offer a competitive salary, bonus, and ongoing stock awards, alongside a benefits package that sets us apart. We cover 100% of medical, dental, and vision premiums for you and your family, and help reduce out-of-pocket costs by funding up to 75% of in-network deductibles. Our benefits also include a 401(k) match with immediate vesting, generous paid time off, 12 weeks of fully paid parental leave, paid family and medical leave for all employees regardless of location, and company-paid short-term disability coverage for up to 20 weeks. Additional perks like wellness programs, tuition reimbursement, and inclusive family-forming support help you thrive at work and beyond. We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.

Lead marketing operations for the launch of a biotech product, ensuring compliance, efficiency, and impactful campaigns. | Extensive experience in pharmaceutical or biotech marketing operations, with leadership in omnichannel strategies, regulatory compliance, and vendor management. | Who We Are: Cogent Biosciences is a publicly traded biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent’s lead program, bezuclastinib, is designed to selectively and potently inhibit exon 17 mutations found within the KIT receptor tyrosine kinase, including KIT D816V. KIT D816V is responsible for driving a rare and serious condition called Systemic Mastocytosis, and exon 17 mutations are also found in patients with gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Bezuclastinib has exhibited promising initial data across all three trials: APEX in AdvSM, SUMMIT in NonAdvSM and PEAK in GIST, including an encouraging safety profile across 600+ patients in single agent and combination dosing. The Role: This critical role will lead the strategic and tactical execution of marketing operations supporting the launch of bezuclastinib, Cogent Biosciences’ key pipeline asset. This role ensures compliant, efficient, and impactful delivery of promotional content, omnichannel campaigns, key marketing KPI’s, and speaker program operations. The Director will serve as a key partner to cross-functional teams including Marketing, Medical Affairs, Regulatory, Legal, Compliance, and external vendors, driving operational excellence and enabling speed-to-market in a highly regulated and complex therapeutic landscape. Responsibilities: Serve as a strategic partner to the bezuclastinib brand team, ensuring Marketing Operations aligns with Cogent Commercial objectives to enhance executional effectiveness. Develop and implement a marketing operations strategy aligned with the unique needs of bezuclastinib and its potential three indications. Drive continuous improvement in operational processes to support agility, scalability, and compliance. Lead budget planning, resource allocation, and vendor oversight to support commercial execution. Promotional Review & Content Approval Key commercial lead for the Cogent internal promotional review process (MLR) and manage the end-to-end content approval process for key commercial materials. Ensure timely and compliant review of promotional materials, including HCP and patient-facing assets. Manage critical systems supporting these processes such as Veeva Vault PromoMats and ensure system optimization for content approval workflows. Omnichannel Campaign Orchestration Work with marketing to ensure the execution of complex customer engagement plans into high-performing omnichannel campaigns across HCP, patient, and caregiver audiences. Collaborate with analytics teams to integrate insights into campaign design and optimization. Ensure systems and platforms readiness to track key data and metrics for campaign effectiveness and measurement. Ensure personalization and precision in outreach, leveraging data and segmentation strategies. Speaker Programs & Event Management Oversee speaker bureau operations, including nomination, contracting, onboarding, and program logistics. Ensure compliance with industry regulations (e.g., FDA, transfer of value) and internal policies. Lead execution of congresses, conventions, and field-sponsored events with a focus on ensuring full optimization of congress presence and execution. Agency & Vendor Management Manage agency selection, onboarding, performance tracking, and contract alignment. Establish KPIs and ensure high-quality deliverables that support brand objectives and scientific integrity. Training & Governance Develop and deliver training programs for internal stakeholders and agency partners. Maintain SOPs and process documentation tailored to the key indications for bezuclastinib marketing operations. Qualifications: Bachelor’s degree in Marketing, Business, Life Sciences, or related field; advanced degree preferred. 8–10+ years of experience in pharmaceutical or biotech industry, with significant experience in oncology and/or rare diseases preferred. 5+ years of developing, accelerating and standardizing omnichannel operations processes aligned with the wider omnichannel vision Proven leadership in promotional review, omnichannel execution, and vendor management. Deep understanding of regulatory requirements, including FDA, PAAB, and global compliance standards. Proven ability to build, lead and develop high-performing teams across multiple marketing operations functions. Strong business acumen with experience translating strategic priorities into operational execution. Experience with key systems and platforms such as Veeva Vault PromoMats and Events highly preferred. Strong analytical, communication, and cross-functional collaboration skills. Ability to thrive in a fast-paced, high-stakes environment with multiple priorities. Salary Range: $USD 215,000 - 270,000 Target Bonus: 20-25% Exact compensation will vary based on skills, experience, and location. Our Locations Waltham, MA: Our headquarters is located in the Greater Boston life sciences community, with an open, collaborative office environment designed to support teamwork and connection. Employees benefit from convenient on-site amenities, including free on-site parking and gym facilities in the building. Boulder, CO: Our Boulder location is home to Cogent’s discovery research organization and a key scientific hub with strong leadership based on site. Situated in the greater Denver-Boulder biopharmaceutical corridor, this office plays a central role in advancing our discovery efforts and pipeline. Our Offer To You At Cogent Biosciences, we offer a competitive salary, bonus, and ongoing stock awards, alongside a benefits package that sets us apart. We cover 100% of medical, dental, and vision premiums for you and your family, and help reduce out-of-pocket costs by funding up to 75% of in-network deductibles. Our benefits also include a 401(k) match with immediate vesting, generous paid time off, 12 weeks of fully paid parental leave, paid family and medical leave for all employees regardless of location, and company-paid short-term disability coverage for up to 20 weeks. Additional perks like wellness programs, tuition reimbursement, and inclusive family-forming support help you thrive at work and beyond. We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.

Lead and oversee Expanded Access Programs, Investigator-Sponsored Trials, and rollover protocols ensuring compliance, strategic alignment, and efficient patient access and retention. | 8+ years pharma/biotech experience including 3+ years managing EAP/IST programs, leadership skills, regulatory knowledge of GCP and FDA Expanded Access, and strong communication and financial management. | Who We Are Cogent Biosciences is a publicly traded biotechnology company dedicated to developing precision therapies for genetically defined diseases. By leveraging validated biology and a rational drug discovery approach, Cogent aims to create real solutions that address the underlying drivers of disease and offer meaningful hope to patient's. The company’s lead therapeutic candidate, bezuclastinib, is a highly selective tyrosine kinase inhibitor designed to potently target KIT D816V and other mutations in KIT exon 17. These mutations are known drivers of systemic mastocytosis (SM) and advanced gastrointestinal stromal tumors (GIST) - both serious conditions driven by oncogenic KIT signaling. Bezuclastinib is currently being evaluated in multiple registration-directed trials across Non-Advanced SM (NonAdvSM), Advanced SM (AdvSM), and GIST. In July 2025, Cogent announced that its registration-direct SUMMIT trial in patients with NonAdvSM achieved statistical significance across all primary and key secondary endpoints, and the company is on track to file its first New Drug Application for this patient population by the end of 2025. The company also remains on track to announce top-line results for its APEX trial in patients with AdvSM in the second half of 2025 and for its PEAK trial in patients with GIST by the end of 2025. The company also has an ongoing Phase 1 study of its novel internally discovered FGFR2 inhibitor, and the Cogent Research Team is developing a portfolio of novel targeted therapies to help patients fighting other serious, genetically driven diseases targeting mutations in ErbB2, PI3Kα and KRAS. Through its commitment to precision medicine and targeted innovation, Cogent Biosciences is working to transform the treatment landscape for patients with serious and underserved diseases. By leveraging validated biology and a rational drug discovery approach, Cogent aims to create real solutions that address the underlying drivers of disease. Our culture of inquisitiveness fuels continuous learning and innovation; we challenge assumptions, ask bold questions, and embrace a mindset of discovery to uncover transformative insights. The Role The Associate Director, Investigator-Initiated Trials & Expanded Access Programs will play a critical role in ensuring continued access to investigational therapies prior to commercialization. This role bridges between Clinical Operations and Medical Affairs and will lead the strategic development and operational oversight of the company's Expanded Access Programs (EAPs), Investigator-Sponsored Trials (ISTs), and Rollover Protocols. This role is responsible for ensuring compliant, efficient, and ethical execution of these programs in alignment with corporate strategy, global regulations, and Good Clinical Practice (GCP). The Associate Director will implement and oversee programs that enhance the patient experience, support trial retention, and maintain compliant access to study drugs beyond clinical trial enrollment. The ideal candidate will have a strong background in clinical operations, project management, and bring strong cross-functional leadership, regulatory knowledge, and a deep commitment to patient-centered care. Key Responsibilities • Expanded Access Program (EAP) Lead • Design, implement, and manage expanded access strategies for Cogent products in compliance with global and country level regulatory requirements and internal SOPs. • Lead cross-functional collaboration to enable timely decision-making, allocate resources efficiently, and maintain a seamless flow of information to internal and external partners. • Oversee all aspects of the program, including timelines, budget, and resources. • Collaborate with legal, pharmacovigilance, supply chain, and relevant cross functional teams to support access and distribution. • Provide training and ongoing support to physicians on EAP program requirements, partnering with Medical Affairs on outreach/engagement strategy supporting access to patients • Contribute to the development of policies and strategies aligned with product lifecycle and global access objectives. • Identify potential risks and develop mitigation strategies. • IST (Investigator-Sponsored Trials) Operational Lead • In partnership with Medical Affairs, provide operational support for Investigator-sponsored Trials • Develop and implement processes to ensure consistent and efficient IST program execution, including tracking project timelines, managing risks, and coordinating with investigators. • Rollover Programs • * Develop, plan, and manage all aspects of clinical trial rollover programs, from feasibility and startup through closeout. • Serve as the primary point of contact for and collaborate with internal and external stakeholders, including Medical Affairs, Regulatory Affairs, investigators, and Contract Research Organizations (CROs). • Ensure all program activities adhere to Good Clinical Practice (GCP), ICH guidelines, and all applicable national and international regulatory requirements. • Develop and implement strategies to ensure efficient patient enrollment and retention within the extension program • Oversee the creation of patient-facing materials, tools, resources to improve continued trial engagement and retention Qualifications • A bachelor's degree in life science, medicine, or a pharmacy-related field is required. An advanced degree (e.g., MS, MPH, PharmD, PhD) is strongly preferred. • 8+ years of relevant experience in the pharmaceutical or biotech industry, with a minimum of 3 years of direct experience managing EAP and/or IST programs. • Demonstrated experience in a leadership or senior role with responsibility for program strategy and oversight. • Regulatory expertise: In-depth knowledge of GCP, FDA regulations governing Expanded Access (21 CFR Part 312), and ethical considerations for clinical research. • Leadership and influence: Proven ability to lead cross-functional teams and influence internal and external stakeholders without direct authority. • Communication: Excellent communication and interpersonal skills, with the ability to navigate sensitive topics with patients and external partners. • Business acumen: Strong financial management skills for budget oversight and contract negotiation. Salary Range 160,000 - 205,000 $USD Target Bonus: 20% Exact compensation will vary based on skills, experience, and location. Our Locations Waltham, MA: Our Boston office includes an open office layout that has recently undergone a makeover designed for collaboration and giving our employees the best work place possible. Free access is provided for both on-site parking and gym facilities in the building. Boulder, CO: We have just moved into our new state-of-the art Research Facility in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor. Our CEO is based full-time in this location and we are proud to call this the home of Cogent’s discovery research organization. Our Offer To You To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), competitive time-off, a 401(k) plan, and commuter/parking benefits. We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.

Lead authoring, reviewing, and quality control of clinical and regulatory documents while collaborating with SMEs and managing contract writers. | Bachelor's degree with 5+ years medical writing experience, strong regulatory knowledge, excellent communication and project management skills. | Who We Are: Cogent Biosciences is a publicly traded biotechnology company dedicated to developing precision therapies for genetically defined diseases. By leveraging validated biology and a rational drug discovery approach, Cogent aims to create real solutions that address the underlying drivers of disease and offer meaningful hope to patient's. The company's lead therapeutic candidate, bezuclastinib, is a highly selective tyrosine kinase inhibitor designed to potently target KIT D816V and other mutations in KIT exon 17. These mutations are known drivers of systemic mastocytosis (SM) and advanced gastrointestinal stromal tumors (GIST) - both serious conditions driven by oncogenic KIT signaling. Bezuclastinib is currently being evaluated in multiple registration-directed trials across Non-Advanced SM (NonAdvSM), Advanced SM (AdvSM), and GIST. In July 2025, Cogent announced that its registration-direct SUMMIT trial in patients with NonAdvSM achieved statistical significance across all primary and key secondary endpoints, and the company is on track to file its first New Drug Application for this patient population by the end of 2025. The company also remains on track to announce top-line results for its APEX trial in patients with AdvSM in the second half of 2025 and for its PEAK trial in patients with GIST by the end of 2025. The company also has an ongoing Phase 1 study of its novel internally discovered FGFR2 inhibitor, and the Cogent Research Team is developing a portfolio of novel targeted therapies to help patients fighting other serious, genetically driven diseases targeting mutations in ErbB2, PI3Kα and KRAS. Through its commitment to precision medicine and targeted innovation, Cogent Biosciences is working to transform the treatment landscape for patients with serious and underserved diseases. By leveraging validated biology and a rational drug discovery approach, Cogent aims to create real solutions that address the underlying drivers of disease. Our culture of inquisitiveness fuels continuous learning and innovation; we challenge assumptions, ask bold questions, and embrace a mindset of discovery to uncover transformative insights. The Role: We are seeking an experienced, collaborative, detail-oriented medical writer with a passion for medical writing. The successful candidate will lead the planning, authoring, reviewing, and QC of clinical and regulatory documents. The individual will work with cross-functional SMEs as well as independently to develop high-quality, scientifically accurate documents. In this role, the successful candidate will collaborate with and may oversee the work of contract writers. In addition, the candidate will contribute to medical writing process development. Responsibilities: • Employ scientific knowledge and analytical skills to author high-quality, scientifically accurate clinical and regulatory documents which may include clinical study protocols and amendments, clinical study reports, Investigator's brochures, common technical document modules, and briefing books • Facilitate document reviews and lead round-table meetings to achieve consensus among stakeholders on document content and strategy • Ensure consistent messaging across documents as appropriate • Represent the Medical Writing department on clinical study teams • Perform and/or manage quality control reviews of clinical and regulatory documents as needed • Collaborate with and manage contract writers as needed • Contribute to the development and implementation of medical writing processes • Adhere to regulatory standards and company SOPs • Perform other medical writing related duties as assigned Qualifications: • Bachelor's degree • Manager: 5+ years of medical writing experience; Sr. Manager: 7+ years of medical writing experience, or with fewer years of experience for individuals with an advanced degree [MS, PhD, MD, PharmD] • Strong knowledge of FDA and ICH guidelines, GCP, and applicable regulatory processes related to document preparation • Proficient in researching and understanding scientific literature and distilling complex topics clearly and accurately • Proficient in interpreting and critically analyzing data and summarizing it clearly and accurately • Strong project management and time management skills • Excellent interpersonal, written, and verbal communication skills • Self-motivated and effective in working with cross-functional teams • Strong computer and software skills (eg, Word, Excel, PowerPoint, Adobe suite, Veeva RIM, SharePoint) and ability to learn new computer applications • Experience as a key contributor or lead author for submissions of regulatory documents is preferred Salary Range: 130,000 - 180,000 $USD Target Bonus: 15% Exact compensation will vary based on skills, experience, and location. Our Locations Waltham, MA: Our Boston office includes an open office layout that has recently undergone a makeover designed for collaboration and giving our employees the best work place possible. Free access is provided for both on-site parking and gym facilities in the building. Boulder, CO: We have just moved into our new state-of-the art Research Facility in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor. Our CEO is based full-time in this location and we are proud to call this the home of Cogent's discovery research organization. Our Offer To You To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), competitive time-off, a 401(k) plan, and commuter/parking benefits. We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.