Chan Zuckerberg Initiative

Lead technical strategy and architecture for internal tools and AI workflows, develop scalable applications, and mentor engineers. | 12+ years building production software with full-stack and cloud infrastructure expertise, fluent in LLM frameworks, RAG, and SaaS API integrations. | The Chan Zuckerberg Initiative was founded in 2015 by Priscilla Chan and Mark Zuckerberg to harness the power of technology to pursue some of society’s most ambitious goals — from curing or preventing all disease to transforming how students learn. At CZI, you’ll join a deeply collaborative, mission-driven community where your work helps drive breakthroughs across our flagship nonprofit organizations, Biohub and Learning Commons. Whether enabling scientific breakthroughs via open science and AI-powered biology or strengthening the tools teachers and students rely on every day, your contributions help turn bold ideas into real-world impact. Our teams operate at the intersection of innovation and scale, building the infrastructure, partnerships, and capabilities that allow scientists, educators, and innovators to tackle some of the most complex challenges of our time — and to do so with urgency, integrity, and optimism. The Team The Operations team is a key partner in enabling Biohub’s pioneering work to combine frontier AI with frontier biology to solve disease and Learning Commons’ mission to build AI infrastructure that aligns how students learn with the tools that shape their learning experiences. Operations includes our Central Tech, Finance, Marketing & Communications, People, and Real Estate / Workplace / Events / Facilities / Security (REWFS) teams. Together, these teams create the systems, programs, and experiences that empower our partners and colleagues across Biohub and Learning Commons to drive impact. This work requires strategic and operational rigor, creativity, and deep collaboration. Whether designing world-class employee experiences, safeguarding data and infrastructure, or shaping how we communicate our impact, Operations plays a critical role in helping deliver meaningful change at scale. The Opportunity Our Central Tech team provides technology and security support for CZI and our grantees. We believe that Engineering, IT and Security are most effective when in sync and learning from each other on a daily basis. Across our three pillars of Infrastructure, Security, and Grantee & Partner Support, we enable our teams to achieve their goals faster and more securely. We leverage technology to automate manual processes, constantly innovate to optimize operations, provide first-class support, and build solutions to enable the scale and execution of our business partners' strategies and initiatives. This role is about building the internal tools and AI-powered workflows that make CZI's employees more effective at the work they do. As the Senior Staff Software Engineer for Internal Tools, you'll set technical direction for the platform — the applications, agents, integrations, and knowledge infrastructure that turn back-office work into something teams can do faster, better, and with more leverage. You'll lead the hardest builds hands-on and be the senior technical voice for this work across the function. This is a high-autonomy, high-impact tech lead IC role. The team is intentionally small — the leverage comes from depth and design discipline, not headcount. Over time, you may take on management of contingent engineering support and a small number of engineers as the team's scope develops. Success looks like applications business teams actually adopt, technical patterns that get reused instead of rebuilt every quarter, and an engineering bar that holds without needing to be enforced. What You'll Do Set technical strategy by defining the architecture and technical roadmap e across the stack — applications, AI agents and workflows, integrations, and knowledge infrastructure Architect and maintain reliable, scalable production applications with a focus on infrastructure automation and governance Design and build the AI layer — custom agents, workflows, and the knowledge and retrieval substrate that lets them reason over connected enterprise data Tech-lead a small team: set the design and code review bar, partner with engineers on what good looks like, mentor contingent engineering support Partner with senior business stakeholders across the org and with embedded engineers in Investments, Biohub, and Learning Commons What You'll Bring 12+ years building production software systems, with meaningful time as a Senior Staff or Principal IC tech-leading small teams Strong full-stack engineering fundamentals — comfortable shipping production applications, backend services, and the integration layer between them Experience operating cloud infrastructure for production systems using industry-standard best practices like Infrastructure as Code (IaC) Strong API integration experience at the enterprise SaaS layer — auth, rate limits, schema drift, failure modes Working fluency with MCP, LLM tool/function calling, current agent frameworks, and retrieval/knowledge infrastructure (knowledge graphs, vector stores, RAG) Comfort with ambiguity; ability to make progress when requirements are evolving Strong stakeholder fluency; you can hold technical conversations with senior business partners without a translator Nice to have: Background in enterprise IT, business systems, or platform engineering; Experience operating in hub-and-spoke models with embedded engineering teams; Direct production experience building LLM-based applications, custom agents, or agentic workflows Compensation The Redwood City, CA base pay range for a new hire in this role is $241,000 – $331,100. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role. Better Together As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Hybrid

Design and deliver internal tools and AI-powered workflows to improve business efficiency. | Senior IC with 5+ years building production software, strong full-stack fundamentals, and experience with LLM-based applications and API integrations. | The Chan Zuckerberg Initiative was founded in 2015 by Priscilla Chan and Mark Zuckerberg to harness the power of technology to pursue some of society’s most ambitious goals — from curing or preventing all disease to transforming how students learn. At CZI, you’ll join a deeply collaborative, mission-driven community where your work helps drive breakthroughs across our flagship nonprofit organizations, Biohub and Learning Commons. Whether enabling scientific breakthroughs via open science and AI-powered biology or strengthening the tools teachers and students rely on every day, your contributions help turn bold ideas into real-world impact. Our teams operate at the intersection of innovation and scale, building the infrastructure, partnerships, and capabilities that allow scientists, educators, and innovators to tackle some of the most complex challenges of our time — and to do so with urgency, integrity, and optimism. The Team The Operations team is a key partner in enabling Biohub’s pioneering work to combine frontier AI with frontier biology to solve disease and Learning Commons’ mission to build AI infrastructure that aligns how students learn with the tools that shape their learning experiences. Operations includes our Central Tech, Finance, Marketing & Communications, People, and Real Estate / Workplace / Events / Facilities / Security (REWFS) teams. Together, these teams create the systems, programs, and experiences that empower our partners and colleagues across Biohub and Learning Commons to drive impact. This work requires strategic and operational rigor, creativity, and deep collaboration. Whether designing world-class employee experiences, safeguarding data and infrastructure, or shaping how we communicate our impact, Operations plays a critical role in helping deliver meaningful change at scale. The Opportunity Our Central Tech team provides technology and security support for CZI and our grantees. We believe that Engineering, IT and Security are most effective when in sync and learning from each other on a daily basis. Across our three pillars of Infrastructure, Security, and Grantee & Partner Support, we enable our teams to achieve their goals faster and more securely. We leverage technology to automate manual processes, constantly innovate to optimize operations, provide first-class support, and build solutions to enable the scale and execution of our business partners' strategies and initiatives. This role is about building the internal tools and AI-powered workflows that make CZI's business teams more effective at the work they do. As a Senior Software Engineer for Internal Tools, you'll own the design and delivery of individual systems end-to-end — applications, agents, integrations, and the knowledge infrastructure that turn back-office work into something teams can do faster, better, and with more leverage. You'll partner with the team's tech lead on architecture and bring strong points of view to that partnership. This is a high-autonomy, high-impact senior IC role on a deliberately small team — the leverage comes from depth and design discipline, not headcount. Success looks like systems you've shipped that business teams adopt and rely on, technical patterns that get reused instead of rebuilt every quarter, and a track record of solid, durable work in a small senior team What You'll Do Own the design and delivery of individual systems end-to-end — from scoping with business stakeholders through production deployment Build the production applications business teams use day-to-day Design and build AI features — custom agents, workflows, and the knowledge and retrieval substrate that lets them reason over connected enterprise data Partner with the tech lead on architecture decisions; contribute strong points of view on tradeoffs, patterns, and reuse Potentially contribute to the team's cloud footprint over time — pragmatic infrastructure decisions, deployment, observability, and reliability for what the team ships, as the scope of the team develops Partner with senior business stakeholders and embedded engineers across the organization What You'll Bring 5+ years building production software systems as a senior IC, with a track record of owning meaningful surfaces end-to-end Strong full-stack engineering fundamentals — comfortable shipping production applications, backend services, and the integration layer between them Direct production experience building LLM-based applications, custom agents, or agentic workflows Strong API integration experience at the enterprise SaaS layer — auth, rate limits, schema drift, failure modes Working fluency with MCP, LLM tool/function calling, current agent frameworks, and retrieval/knowledge infrastructure (knowledge graphs, vector stores, RAG) Comfort with ambiguity; ability to make progress when requirements are evolving Strong stakeholder fluency; you can hold technical conversations with business partners without a translator Nice to have: Background in enterprise IT, business systems, or platform engineering; experience operating cloud infrastructure (AWS, Terraform) for production systems Compensation The Redwood City, CA base pay range for a new hire in this role is $190,000 – $238,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role. Better Together As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Hybrid

Design and implement security tooling and frameworks to eliminate vulnerabilities and lead technical security projects. | 5+ years technical program management in application security with hands-on DevSecOps, cloud-native, and container security experience. | The Chan Zuckerberg Initiative was founded in 2015 by Priscilla Chan and Mark Zuckerberg to harness the power of technology to pursue some of society’s most ambitious goals — from curing or preventing all disease to transforming how students learn. At CZI, you’ll join a deeply collaborative, mission-driven community where your work helps drive breakthroughs across our flagship nonprofit organizations, Biohub and Learning Commons. Whether enabling scientific breakthroughs via open science and AI-powered biology or strengthening the tools teachers and students rely on every day, your contributions help turn bold ideas into real-world impact. Our teams operate at the intersection of innovation and scale, building the infrastructure, partnerships, and capabilities that allow scientists, educators, and innovators to tackle some of the most complex challenges of our time — and to do so with urgency, integrity, and optimism. The Team The Operations team is a key partner in enabling Biohub’s pioneering work to combine frontier AI with frontier biology to solve disease and Learning Commons’ mission to build AI infrastructure that aligns how students learn with the tools that shape their learning experiences. Operations includes our Central Tech, Finance, Marketing & Communications, People, and Real Estate / Workplace / Events / Facilities / Security (REWFS) teams. Together, these teams create the systems, programs, and experiences that empower our partners and colleagues across Biohub and Learning Commons to drive impact. This work requires strategic and operational rigor, creativity, and deep collaboration. Whether designing world-class employee experiences, safeguarding data and infrastructure, or shaping how we communicate our impact, Operations plays a critical role in helping deliver meaningful change at scale. The Opportunity We are seeking a Technical Program Manager with expertise in Application Security, specifically in identifying vulnerabilities and then scoping and implementing novel solutions to eliminate those weaknesses at scale. We don't just identify and fix security vulnerabilities - we go beyond by creating paved roads and secure frameworks to avoid security vulnerabilities in the first place. You will be expected to operate using in-depth subject-matter knowledge at a technical level with developers and engineers across large organizations. Your security and development experience will be relied upon to provide secure foundations to the application and infrastructure teams that underpin the CZI Enterprise. The role will help shape the product and application security that protects scientific and educational innovation at the Chan Zuckerberg Initiative, Biohub and Learning Commons. You’ll work alongside a dynamic team of engineers, Product Managers, and Security Professionals, building shared tools and platforms that support a diverse group of Research Scientists, Data Scientists, AI Researchers, and Engineers tackling some of the world’s most complex problems. As part of the Information Security team, your work will directly impact all of CZI’s initiatives by ensuring the security and scalability of the technology solutions that drive our mission forward. What You'll Do Conceive, design, develop, and improve industry-leading security tooling, automation, architecture, and/or frameworks that enable enterprise teams at scale to deliver applications and services with appropriate security controls to meet evolving requirements for security and privacy Identify and eliminate classes of security problems by shifting detection and prevention left into the development workflow Provide just-in-time, actionable, technical security guidance to enterprise application and service teams Ensure prioritization, resourcing, and timely delivery of work within a changing business environment Collaborate with cross-functional teams to ensure security work is being prioritized and addressed Drive end-to-end execution of technical security projects, including requirements gathering, scoping, status updates, and delivery milestones. Establish and report metrics to track compliance, program health, and ongoing risk posture. Coordinate with third-party vendors and auditors to augment internal security capabilities Serve as a subject matter expert on infrastructure, architecture, and application security, offering guidance to technical and non-technical stakeholders. Support security reviews, threat modeling, and incident response efforts for applications and production infrastructure. What You'll Bring 5+ years of technical program management or equivalent experience, with a specific focus on security or application security. Demonstrated proficiency with secure SDLC processes and best practices for integrating security throughout the software development lifecycle. Hands-on experience designing and managing security controls within CI/CD pipelines, using automation frameworks to enable secure code delivery and rapid remediation. Familiarity with threat modeling, static and dynamic application security testing (SAST/DAST), and software composition analysis (SCA) tools. Deep understanding of DevSecOps principles, security automation, and infrastructure-as-code security. Experience driving the adoption of vulnerability management, architectural best practices, and incident response for cloud-native and distributed applications. Knowledge of container security (Docker, Kubernetes), microservices architectures, and cloud platform security (AWS, Azure, GCP). Experience leading end-to-end security architecture design and governance across complex, cloud-native, and hybrid enterprise environments, aligning security capabilities to business and risk objectives. Proven ability to define and maintain reference architectures, security patterns, and control standards spanning network, identity, data protection, and application security domains. Skilled in conducting architecture risk assessments and design reviews, ensuring new and existing solutions meet zero trust, defense-in-depth, and compliance requirements in regulated industries. Compensation The Redwood City, CA base pay range for a new hire in this role is $190,000.00 - $261,800.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. This position may be eligible to participate in CZI's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with CZI's total rewards philosophy and may vary by role. Better Together As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Hybrid