Arcellx

Provide strategic medical oversight for clinical development programs, including study design, safety monitoring, and regulatory interactions. | MD degree with hematologic malignancy experience, 8+ years in clinical trials, regulatory and leadership skills. | Who We Are Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work. What Matters to Us Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team. Arcellx Core Values Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work. Think ‘we’ before ‘me’: We prioritize collective success, collaborating and supporting one another to achieve our shared goals. Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what’s right. How You’ll Make a Difference As a senior medical director at Arcellx, you’ll provide strategic oversight to clinical development programs across indications from early to late-stage development. Your medical leadership will help advance our therapies to patients in need. The “Fine Print” – What You’ll Do Clinical Development Strategy: Contribute to the development and implementation of clinical development plans for cell therapy programs. Provide medical oversight and strategic input into study design, protocol development, and endpoint selection. Medical Monitoring and Safety Oversight: Serve as the medical lead for clinical trials, including oversight of patient safety and adverse event management. Collaborate with clinical operations and pharmacovigilance teams to ensure effective medical monitoring and risk management. Regulatory Interactions and Submissions: Interface with regulatory authorities on clinical development plans, study protocols, and data submissions. Contribute to the preparation of regulatory documents (e.g., IND/IMPD, BLA/MAA) and responses to inquiries. Clinical Data Analysis and Interpretation: Analyze clinical trial data, interpret results, and contribute to the development of clinical study reports and publications. Work closely with biostatistics and data management teams to ensure robust data analysis and reporting. Key Opinion Leader Engagement: Collaborate with external experts, investigators, and advisory boards to gather insights and support clinical trial execution. Represent the company at scientific conferences, symposia, and external meetings. Cross-functional Collaboration: Partner with translational research, manufacturing, and regulatory affairs teams to integrate medical insights into program strategies. Collaborate with business development and commercial teams to support product positioning and market access strategies. Skills and Experience We Look For Medical Doctor (M.D.) or non-US equivalent of M.D. degree with hematologic malignancy experience in an academic or hospital environment. Completion of a residency program and oncology focused subspecialty fellowship strongly preferred. 8+ years of relevant clinical trial experience in the pharmaceutical industry, academia, or equivalent, including: Regulatory submission support Medical writing oversight for trial related documents Strategic vision including understanding of the field, knowledge of competitive landscape, and network of academic investigators. Well-honed communication skills with the ability to collaborate effectively with cross-functional teams. Must possess excellent oral and written English communication skills. Demonstrated success addressing complex problems and creating solutions for one or more programs. Proven leadership skills with the ability to influence and guide decision making in a fast-paced environment. Rewards at Arcellx Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits. The estimated base salary range for this position is $315,000 - $370,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required. Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more. Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to www.arcellx.com.

Build and optimize in vitro immunogenicity assays using flow cytometry, documenting procedures, and collaborating with cross-functional teams. | BS or MS with 2+ years of assay development experience in the pharmaceutical industry, expertise in cell culture, flow cytometry, and immunology. | Who We Are Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work. What Matters to Us Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team. Arcellx Core Values Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work. Think ‘we’ before ‘me’: We prioritize collective success, collaborating and supporting one another to achieve our shared goals. Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what’s right. The “Fine Print” As a contractor on our Cell Bio team, you will... Build an in vitro immunogenicity assay using HLA-Typed PBMCs, assessing T-cell activation and proliferation as measured through flow cytometry. Through the use of clinical benchmarks and in-house data, build a relative risk assessment for clinical immunogenicity based on these in vitro. Careful documentation of assay development, including drafting SOPs and electronic lab notebook entries. Contribute to one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable data-driven decisions. Design and execute experiments independently with minimal supervision, as well as effectively plan and organize work activities and prioritize task completion. Other duties as assigned. Skills and Experience We Look For BS and 5+ years or MS and 2+ years of assay development experience within the pharmaceutical industry setting. Expertise in cell culture with a focus on manipulating PBMCs and T-cells, including activation, purification, and cryopreservation. Working knowledge of immunology and a familiarity with markers of activation for phenotyping of T-cells by flow cytometry. Expertise in flow cytometry panel design and optimization. Expertise in immune cell assays including multiparameter flow cytometry and in vitro assays to determine T-cell activation or proliferation (e.g., BrdU incorporation). Preferably experience with BD instruments or Cytek Aurora for flow cytometry. Proficient in common software, including GraphPad Prism, FlowJo, and Office suite. Commitment to ethical scientific investigations and rigorous experimental methods. Ability and desire to multitask and function in a fast-paced environment. Interpersonal skills that promote a collaborative and productive lab environment. Effective and efficient written and oral communication skills. Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to www.arcellx.com.