The Jackson Laboratory

Compensation

Full Description

Position Summary The Research Assistant III (RAIII) will provide advanced research support focused on single-cell and multi-omic data analysis in immunology/cancer and manuscript development for near-term submission. This role will work closely with the PI and project team to convert existing datasets into publication-ready results by conducting rigorous analyses, generating figures/tables, drafting manuscript sections, and maintaining reproducible documentation. The successful candidate is independent, deadline-driven, and comfortable collaborating across disciplines. Key Responsibilities Single-cell & immuno-oncology data analysis Perform QC, preprocessing, integration, and annotation of single-cell RNA-seq and flow cytometry datasets from immuno-oncology studies. Analyze in vivo histology data demonstrating hyperplasia and tumor development in in vivo model systems +/- therapy. Identify and interpret immune/tumor states (e.g., NK/T cell subsets, myeloid populations), differential abundance/expression, pathway/activity scoring, and cell-cell interaction analyses in the context of tumor development and disease progression. Produce publication-quality visualizations (UMAP/TSNE, dot/violin plots, heatmaps, composition plots, trajectory/pseudotime where relevant) and concise analytical summaries for internal review. Ensure reproducibility: maintain well-documented scripts/notebooks, organized outputs, and clear analysis logs suitable for Methods reporting. Manuscript writing & figure assembly Draft and revise Results, Methods, and figure legends (and support Introduction/Discussion as needed) for immunology/cancer manuscripts. Build and refine figure panels and tables; ensure consistency between text, statistics, and underlying data. Manage references and formatting and support journal submission requirements (as assigned). Incorporate PI/co-author feedback efficiently; support responses to reviewer comments if revisions occur during the appointment. Project coordination & quality Track deliverables and deadlines; maintain version control for documents/figures and clear handoffs to the team. Follow data governance, confidentiality, and research integrity standards; handle sensitive research data appropriately. Required Qualifications M.S. required (or higher) in Immunology with additional knowledge in Bioinformatics, Computational Biology, and Biostatistics. Demonstrated experience analyzing single-cell datasets (scRNA-seq required; additional modalities a plus). Proficiency in R and/or Python for analysis and visualization (e.g., Seurat/Scanpy and relevant ecosystem tools). Experience with immune-oncology analytical workflows: batch correction/integration, cell-type annotation, gene set enrichment, single-cell integration, as well as detailed analyses of flow cytometry and histology datasets Experience with and ability to communicate results to mixed wet-lab/computational audiences; ability to translate analyses into clear narrative text. Proficiency in FlowJo, Prism, and Microsoft Word. Proven ability to produce publication-ready figures and contribute substantially to scientific manuscripts. Strong organizational skills, attention to detail, and ability to work independently in a remote, deadline-driven setting. Preferred Qualifications Prior authorship or major contribution to peer-reviewed publications in immunology and/or cancer. Work Environment Remote, part-time position based out of Farmington, CT Must maintain secure handling of research data and comply with institutional policies. Temporary Appointment Statement This is a temporary role expected to last 3–4 months. Continued employment beyond the appointment period is not implied. $27.29/hour About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org. EEO Statement: The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. Bar Harbor: The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries. Ellsworth: The Charles E. Hewett Center in Ellsworth, Maine, is a state-of-the-art facility that serves researchers world wide. The facility represents the culmination of nine decades of unmatched experience and leadership in breeding and caring for laboratory mice. Ellsworth, Maine, is one of Maine’s fastest growing cities. With a growth rate of nearly 20%, Ellsworth is a bustling year-round community and acts as a hub for surrounding towns. It is located nearby Acadia National Park and hosts numerous special events, concerts and festivals each year. Residents have access to fabulous shopping, recreation, museums, galleries, and dining at a variety of independent restaurants. Farmington: JAX Genomic Medicine is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX Genomic Medicine’s research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup. JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state-of-the-art computing facilities and laboratories. In Connecticut, JAX resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX Genomic Medicine is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports. Sacramento: The JAX® Mice, Clinical and Research Services facility is located in Sacramento, the state capital of California. Sacramento is less than a two-hour drive from San Francisco, Napa Valley, and scenic Lake Tahoe, and a short flight to both Los Angeles and Orange County. Sacramento is the birthplace of the nation’s Farm to Fork movement, and offers excellent restaurants, gastro-pubs, wineries, theaters, and museums. Outdoor activities are plentiful: Boating, white water rafting, and riding the scenic bicycle trails are popular. Housing and other costs of living are more affordable in Sacramento and its surrounding suburbs than in most other neighboring areas in the North Bay, making Sacramento one of the hottest housing markets in the country year after year. Augusta: JAX’s Maine Cancer Genomics Initiative (MCGI) is located in Augusta, Maine, in the Harold Alfond Center for Cancer Care (HACCC), at Maine General Hospital. It began operations in 2016 with three overarching goals: to provide cancer genomic testing for Maine cancer patients; to develop and deliver physician education about clinical genomic cancer diagnostics; and to build a network in Maine of oncology practices conducting studies in genomic medicine.