City Therapeutics

Compensation

Full Description

Position Summary: City Therapeutics is looking for an innovative and results-driven Senior Scientist/Early Program Lead to join our Biology team. The successful candidate will lead an early-stage program from initial screening through the identification of a clinical development candidate for evaluation in humans. As City Therapeutics is both a drug development and platform company, this role is central to our success in delivering transformative therapies. Please note this is a full-time 5 days a week onsite opportunity. Key Responsibilities: Drive lead finding activities including screening in vitro and in vivo based on mRNA and protein levels. Analyze and interpret large datasets and large screening sets to efficiently narrow and prioritize candidates through the screening funnel, accelerating program timelines Lead cross-functional biology, pharmacology, and safety studies. Qualifications: PhD with 2+ years of drug discovery/ lead finding industry experience M.Sc. with 7+ years of academic/ industry/ drug discovery/ lead finding experience Track-record of success via publications and/ or clinical drug candidates Assay development: Developing tools to measure target expression with high specificity/sensitivity and consistency (eg, ELISA, qPCR, flow cytometry, western blot, RNAseq (NGS) workflows). Demonstrated expertise with cancer cell lines, primary human hepatocyte cell lines, hematopoietic cells. Proven ability to troubleshoot complex assay workflows resolve technical challenges. In vivo models: Develop tools and characterize/ develop complex rodent disease models. Experience with siRNA or gene editing technologies, particularly in high -priority project environments. Ability to incorporate platform learnings into a fast-moving program. Broad expertise across multiple tissue types or disease areas. Must have a high scientific acumen with the ability to adapt and learn new biology on the fly by leveraging literature to address key questions and troubleshoot. Additional Skills: Detail oriented with a proven track record of maintaining organized and accurate documentation. Significant and frequent benching experience is preferred. Motivated team player that is comfortable working cross functionally and collaboratively with dynamic teams to achieve a common goal quickly and efficiently. The ideal candidate prioritizes data integrity, approaches challenges with an open-mind, and embraces negative data –using strong adherence to scientific principles to guide the ultimate success of the program. Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including relevant skills, experience, internal equity, relevant education or training and market dynamics. In addition, this role is eligible for an annual cash bonus and equity compensation. City Therapeutics offers a comprehensive and competitive benefits package including medical, dental, vision, life insurance, health and dependent care FSA accounts, HSA/HRA accounts with company contributions, in addition to a 401(k) with competitive company match. Per Year Salary Range: $135,000 to $154,000. City Therapeutics is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. City Therapeutics is accepting resumes/CVs from direct applicants only. Recruitment agency submissions will not be accepted at this time.