Alnylam Pharmaceuticals

Compensation

Full Description

The Senior Director, Global Trial Strategy & Operations ensures high-quality execution across programs through strategic influence, operational frameworks, and portfolio-level visibility. He/she partners with program, study, and functional leaders to drive disciplined planning, milestone transparency, risk mitigation, and alignment to strategic priorities. Reporting directly to the VP, Study Management, the Senior Director works in close collaboration to operationalize strategic priorities across the Cardiovascular and TTR portfolio. Acting on behalf of the VP when delegated, he/she may represent the portfolio in leadership and governance settings to reinforce alignment and support informed, timely decision-making. He/she may/may not manage direct reports but drives impact by influencing delivery and team effectiveness through clarity of expectations, strategic frameworks, and cross-functional alignment. He/she ensures that teams operate with rigor, that plans are well defined and maintained, and that performance insights drive continuous improvement across the portfolio. He/she contributes to the continued evolution of Clinical Operations and GTSO by participating in and leading initiatives, establishing scalable practices, operating models, and delivery standards that enhance efficiency, quality, consistency, and inspection readiness. He/she will work closely with CRO partners to ensure aligned execution against scope of work, proactive risk management, and focus on critical path and priority deliverables. This includes developing best practices for vendor oversight, communication cadence, issue escalation, and performance monitoring across the Cardiovascular and TTR portfolio. The Senior Director will also assist in financial oversight across programs, including budget tracking, investment planning cycles, annual operating planning, and long‐range planning. Additionally, he/she will partner closely with other clinical operations functions—including SM&H, GTO, CPS, and cross-functional program teams—to ensure alignment, process improvements, and delivery excellence. Develop portfolio-level tracking mechanisms, dashboards, KPIs, and performance analytics to support transparency and data-driven decision-making. Develop, institutionalize, and continuously refine best practices, operating models, playbooks, and standards that reinforce planning rigor, predictable execution, and operational excellence. Collaborate with cross-functional leaders to support operational readiness, including inspection readiness, vendor oversight frameworks, and compliance. Establish and evolve operating rhythms and governance structures that streamline communication, clarify accountability, and enable timely decisions across programs. Assist in financial oversight across programs, including forecasting, budget management, investment planning, and long-range portfolio planning. Bachelor's degree in Life Sciences or related field required; advanced degree preferred. 12+ years of experience in global clinical trial execution within biopharma or CRO environments, with deep operational leadership across full study lifecycle. Demonstrated success operating as a direct report to senior executives and partnering closely at the leadership level to translate strategic priorities into operational execution. Proven track record influencing without direct authority across senior operational and functional leadership. Expertise in clinical operations strategy, program planning, risk management, trial delivery models, and cross-functional execution. Experience developing or implementing operational frameworks, governance models, or delivery standards. Strong presence in senior forums with ability to synthesize complex information and drive alignment through compelling communication. Strong understanding of global regulatory expectations and compliance requirements for clinical trial conduct. Excellent written, verbal, and presentation communication skills. Ability to travel up to 30%. Highly self-directed with ability to drive execution across multiple programs simultaneously. Strong critical thinking, analytical rigor, and ability to navigate ambiguity and drive clarity of action. Skilled influencer able to align diverse stakeholders around shared priorities. Comfortable operating across geographies and time zones in a complex matrix environment. Demonstrated ability to drive impact through strategic frameworks, insights, and alignment rather than formal authority. Operates effectively in a dynamic, fast-paced environment with evolving organizational needs.